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The relationship of indoxyl sulfate and p-cresyl sulfate with target cardiovascular proteins in hemodialysis patients

Wu, Ping-Hsun, 1982- (författare)
Uppsala universitet,Endokrinologi och mineralmetabolism,Kaohsiung Med Univ, Grad Inst Clin Med, Coll Med, Kaohsiung, Taiwan.;Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung, Taiwan.;Kaohsiung Med Univ Hosp, Div Nephrol, Dept Internal Med, 100 Shih Chuan 1st Rd, Kaohsiung 807, Taiwan.
Yi-Ting, Lin, 1981- (författare)
Uppsala universitet,Molekylär epidemiologi,Kaohsiung Med Univ, Grad Inst Clin Med, Coll Med, Kaohsiung, Taiwan.;Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung, Taiwan.;Kaohsiung Med Univ Hosp, Dept Family Med, Kaohsiung, Taiwan.
Chiu, Yi-Wen (författare)
Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung, Taiwan.;Kaohsiung Med Univ, Fac Renal Care, Coll Med, Kaohsiung, Taiwan.;Kaohsiung Med Univ Hosp, Div Nephrol, Dept Internal Med, 100 Shih Chuan 1st Rd, Kaohsiung 807, Taiwan.
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Baldanzi, Gabriel (författare)
Uppsala universitet,Molekylär epidemiologi
Huang, Jiun-Chi (författare)
Kaohsiung Med Univ, Grad Inst Clin Med, Coll Med, Kaohsiung, Taiwan.;Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung, Taiwan.;Kaohsiung Med Univ Hosp, Div Nephrol, Dept Internal Med, 100 Shih Chuan 1st Rd, Kaohsiung 807, Taiwan.;Kaohsiung Med Univ, Kaohsiung Municipal Siaogang Hosp, Dept Internal Med, Kaohsiung, Taiwan.
Liang, Shih-Shin (författare)
Kaohsiung Med Univ, Dept Biotechnol, Coll Life Sci, Kaohsiung, Taiwan.
Lee, Su-Chu (författare)
Kaohsiung Med Univ Hosp, Div Nephrol, Dept Internal Med, 100 Shih Chuan 1st Rd, Kaohsiung 807, Taiwan.
Chen, Szu-Chia (författare)
Kaohsiung Med Univ, Grad Inst Clin Med, Coll Med, Kaohsiung, Taiwan.;Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung, Taiwan.;Kaohsiung Med Univ Hosp, Div Nephrol, Dept Internal Med, 100 Shih Chuan 1st Rd, Kaohsiung 807, Taiwan.
Hsu, Ya-Ling (författare)
Kaohsiung Med Univ, Grad Inst Med, Coll Med, Kaohsiung, Taiwan.
Kuo, Mei-Chuan (författare)
Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung, Taiwan.;Kaohsiung Med Univ, Fac Renal Care, Coll Med, Kaohsiung, Taiwan.;Kaohsiung Med Univ Hosp, Div Nephrol, Dept Internal Med, 100 Shih Chuan 1st Rd, Kaohsiung 807, Taiwan.
Hwang, Shang-Jyh (författare)
Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung, Taiwan.;Kaohsiung Med Univ, Fac Renal Care, Coll Med, Kaohsiung, Taiwan.;Kaohsiung Med Univ Hosp, Div Nephrol, Dept Internal Med, 100 Shih Chuan 1st Rd, Kaohsiung 807, Taiwan.
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 (creator_code:org_t)
2021-02-15
2021
Engelska.
Ingår i: Scientific Reports. - : Springer Nature. - 2045-2322. ; 11
Relaterad länk:
https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
https://www.nature.c...
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Protein-bound uremic toxins (Indoxyl sulfate [IS] and p-cresyl sulfate [PCS]) are both associated with cardiovascular (CV) and all-cause mortality in subjects with chronic kidney disease (CKD). Possible mechanisms have not been elucidated. In hemodialysis patients, we investigated the relationship between the free form of IS and PCS and 181 CV-related proteins. First, IS or PCS concentrations were checked, and high levels were associated with an increased risk of acute coronary syndrome (ACS) in 333 stable HD patients. CV proteins were further quantified by a proximity extension assay. We examined associations between the free form protein-bound uremic toxins and the quantified proteins with correction for multiple testing in the discovery process. In the second step, the independent association was evaluated by multivariable-adjusted models. We rank the CV proteins related to protein-bound uremic toxins by bootstrapped confidence intervals and ascending p-value. Six proteins (signaling lymphocytic activation molecule family member 5, complement component C1q receptor, C-C motif chemokine 15 [CCL15], bleomycin hydrolase, perlecan, and cluster of differentiation 166 antigen) were negatively associated with IS. Fibroblast growth factor 23 [FGF23] was the only CV protein positively associated with IS. Three proteins (complement component C1q receptor, CCL15, and interleukin-1 receptor-like 2) were negatively associated with PCS. Similar findings were obtained after adjusting for classical CV risk factors. However, only higher levels of FGF23 was related to increased risk of ACS. In conclusion, IS and PCS were associated with several CV-related proteins involved in endothelial barrier function, complement system, cell adhesion, phosphate homeostasis, and inflammation. Multiplex proteomics seems to be a promising way to discover novel pathophysiology of the uremic toxin.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Urology and Nephrology (hsv//eng)

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