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  • Tuisku, JouniUniv Turku, Turku PET Ctr, Turku, Finland.;Turku Univ Hosp, Turku PET Ctr, POB 52, Turku 20521, Finland. (author)

Effects of age, BMI and sex on the glial cell marker TSPO : a multicentre [11C]PBR28 HRRT PET study

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • 2019-07-30
  • Springer,2019
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-440710
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-440710URI
  • https://doi.org/10.1007/s00259-019-04403-7DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-175038URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:141752010URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Purpose The purpose of this study was to investigate the effects of ageing, sex and body mass index (BMI) on translocator protein (TSPO) availability in healthy subjects using positron emission tomography (PET) and the radioligand [C-11]PBR28. Methods [C-11]PBR28 data from 140 healthy volunteers (72 males and 68 females; N = 78 with HAB and N = 62 MAB genotype; age range 19-80 years; BMI range 17.6-36.9) were acquired with High Resolution Research Tomograph at three centres: Karolinska Institutet (N = 53), Turku PET centre (N = 62) and Yale University PET Center (N = 25). The total volume of distribution (V-T) was estimated in global grey matter, frontal, temporal, occipital and parietal cortices, hippocampus and thalamus using multilinear analysis 1. The effects of age, BMI and sex on TSPO availability were investigated using linear mixed effects model, with TSPO genotype and PET centre specified as random intercepts. Results There were significant positive correlations between age and V-T in the frontal and temporal cortex. BMI showed a significant negative correlation with V-T in all regions. Additionally, significant differences between males and females were observed in all regions, with females showing higher V-T. A subgroup analysis revealed a positive correlation between V-T and age in all regions in male subjects, whereas age showed no effect on TSPO levels in female subjects. Conclusion These findings provide evidence that individual biological properties may contribute significantly to the high variation shown in TSPO binding estimates, and suggest that age, BMI and sex can be confounding factors in clinical studies.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Plaven-Sigray, PontusKarolinska Inst & Stockholm Cty, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden. (author)
  • Gaiser, Edward C.Yale Univ, Dept Radiol & Biomed Imaging, PET Ctr, New Haven, CT 06520 USA.;Yale Univ, Dept Psychiat, New Haven, CT 06511 USA. (author)
  • Airas, LauraUniv Turku, Turku PET Ctr, Turku, Finland.;Turku Univ Hosp, Div Clin Neurosci, Turku, Finland. (author)
  • Al-Abdulrasul, HaidarUniv Turku, Turku PET Ctr, Turku, Finland.;Turku Univ Hosp, Div Clin Neurosci, Turku, Finland. (author)
  • Bruck, AnnaUniv Turku, Turku PET Ctr, Turku, Finland.;Turku Univ Hosp, Div Clin Neurosci, Turku, Finland. (author)
  • Carson, Richard E.Yale Univ, Dept Radiol & Biomed Imaging, PET Ctr, New Haven, CT 06520 USA. (author)
  • Chen, Ming-KaiYale Univ, Dept Radiol & Biomed Imaging, PET Ctr, New Haven, CT 06520 USA. (author)
  • Cosgrove, Kelly P.Yale Univ, Dept Radiol & Biomed Imaging, PET Ctr, New Haven, CT 06520 USA.;Yale Univ, Dept Psychiat, New Haven, CT 06511 USA. (author)
  • Ekblad, LauraUniv Turku, Turku PET Ctr, Turku, Finland. (author)
  • Esterlis, IrinaYale Univ, Dept Psychiat, New Haven, CT 06511 USA. (author)
  • Farde, LarsKarolinska Institutet (author)
  • Forsberg, AntonKarolinska Institutet (author)
  • Halldin, ChristerKarolinska Institutet (author)
  • Helin, SemiUniv Turku, Turku PET Ctr, Turku, Finland. (author)
  • Kosek, EvaKarolinska Institutet(Swepub:uu)evako353 (author)
  • Lekander, MatsStockholms universitet,Stressforskningsinstitutet,Psykologiska institutionen,Karolinska Institutet, Sweden,Karolinska Inst, Dept Clin Neuroscience, Stockholm, Sweden.;Stockholm Univ, Dept Psychol, Stress Res Inst, Stockholm, Sweden.(Swepub:su)mleka (author)
  • Lindgren, NooraUniv Turku, Turku PET Ctr, Turku, Finland. (author)
  • Marjamaki, PaiviUniv Turku, Turku PET Ctr, Turku, Finland. (author)
  • Rissanen, EeroUniv Turku, Turku PET Ctr, Turku, Finland.;Turku Univ Hosp, Div Clin Neurosci, Turku, Finland. (author)
  • Sucksdorff, MarcusUniv Turku, Turku PET Ctr, Turku, Finland.;Turku Univ Hosp, Div Clin Neurosci, Turku, Finland. (author)
  • Varrone, AndreaStockholms universitet,Stressforskningsinstitutet,Psykologiska institutionen,Karolinska Institutet, Sweden; Stockholm County, Sweden,Karolinska Inst & Stockholm Cty, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden.;Stockholm Univ, Dept Psychol, Stress Res Inst, Stockholm, Sweden. (author)
  • Collste, Karin (author)
  • Gallezot, Jean-Dominique (author)
  • Hillmer, Ansel (author)
  • Huang, Yiyun (author)
  • Hoglund, Caroline O. (author)
  • Johansson, JarkkoKarolinska Institutet (author)
  • Jucaite, AurelijaKarolinska Institutet (author)
  • Lampa, Jon (author)
  • Nabulsi, Nabeel (author)
  • Pittman, Brian (author)
  • Sandiego, Christine M. (author)
  • Stenkrona, PerKarolinska Institutet (author)
  • Rinne, JuhaUniv Turku, Turku PET Ctr, Turku, Finland.;Turku Univ Hosp, Div Clin Neurosci, Turku, Finland. (author)
  • Matuskey, DavidYale Univ, Dept Radiol & Biomed Imaging, PET Ctr, New Haven, CT 06520 USA.;Yale Univ, Dept Psychiat, New Haven, CT 06511 USA. (author)
  • Cervenka, SimonKarolinska Institutet(Swepub:uu)simce160 (author)
  • Univ Turku, Turku PET Ctr, Turku, Finland.;Turku Univ Hosp, Turku PET Ctr, POB 52, Turku 20521, Finland.Karolinska Inst & Stockholm Cty, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden. (creator_code:org_t)

Related titles

  • In:European Journal of Nuclear Medicine and Molecular Imaging: Springer46:11, s. 2329-23381619-70701619-7089

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