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Test-retest reprodu...
Test-retest reproducibility of [C-11]PBR28 binding to TSPO in healthy control subjects
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- Collste, K. (författare)
- Karolinska Institutet
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- Forsberg, A. (författare)
- Karolinska Institutet
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- Varrone, A. (författare)
- Karolinska Institutet
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- Amini, N. (författare)
- Karolinska Institutet
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- Aeinehband, S. (författare)
- Karolinska Inst, Neuroimmunol Unit, Dept Clin Neurosci, Stockholm, Sweden.
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- Yakushev, I. (författare)
- Karolinska Inst, Ctr Psychiat Res, Dept Clin Neurosci, Stockholm, Sweden.;Tech Univ Munich, Dept Nucl Med, D-80290 Munich, Germany.;Tech Univ Munich, TUM Neuroimaging Ctr TUM NIC, D-80290 Munich, Germany.
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- Halldin, C. (författare)
- Karolinska Institutet
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- Farde, L. (författare)
- Karolinska Institutet
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- Cervenka, Simon (författare)
- Karolinska Institutet
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Karolinska Institutet Karolinska Inst, Neuroimmunol Unit, Dept Clin Neurosci, Stockholm, Sweden (creator_code:org_t)
- 2015-08-22
- 2016
- Engelska.
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Ingår i: European Journal of Nuclear Medicine and Molecular Imaging. - : SPRINGER. - 1619-7070 .- 1619-7089. ; 43:1, s. 173-183
- Relaterad länk:
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https://zenodo.org/r...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Purpose The PET radioligand [C-11]PBR28 binds to the translocator protein (TSPO), a marker of brain immune activation. We examined the reproducibility of [C-11]PBR28 binding in healthy subjects with quantification on a regional and voxel-by-voxel basis. In addition, we performed a preliminary analysis of diurnal changes in TSPO availability. Methods Twelve subjects were examined using a high-resolution research tomograph and [C-11]PBR28, six in the morning and afternoon of the same day, and six in the morning on two separate days. Regional volumes of distribution (V-T) were derived using a region-of-interest based two-tissue compartmental analysis (2TCM), as well as a parametric approach. Metabolite-corrected arterial plasma was used as input function. Results For the whole sample, the mean absolute variability in V (T) in the grey matter (GM) was 18.3 +/- 12.7 %. Intraclass correlation coefficients in GM regions ranged from 0.90 to 0.94. Reducing the time of analysis from 91 to 63 min yielded a variability of 16.9 +/- 14.9 %. There was a strong correlation between the parametric and 2TCM-derived GM values (r=0.99). A significant increase in GM V-T was observed between the morning and afternoon examinations when using secondary methods of quantification (p=0.028). In the subjects examined at the same time of the day, the absolute variability was 15.9 +/- 12.2 % for the 91-min 2TCM data. Conclusion V-T of [C-11]PBR28 binding showed medium reproducibility and high reliability in GM regions. Our findings support the use of parametric approaches for determining [C-11]PBR28 V-T values, and indicate that the acquisition time could be shortened. Diurnal changes in TSPO binding in the brain may be a potential confounder in clinical studies and should be investigated further.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Nyckelord
- C-11
- PBR28
- PET
- Brain imaging
- Test-retest
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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