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Sökning: L773:2352 8729 > (2018) > In vivo coupling of...

  • Mak, ElijahDepartment of Psychiatry, University of Cambridge, Cambridge, UK (författare)

In vivo coupling of tau pathology and cortical thinning in Alzheimer's disease

  • Artikel/kapitelEngelska2018

Förlag, utgivningsår, omfång ...

  • 2018-09-17
  • Wiley,2018
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-440805
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-440805URI
  • https://doi.org/10.1016/j.dadm.2018.08.005DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:230426064URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Introduction: The deposition of neurofibrillary tangles in neurodegenerative disorders is associated with neuronal loss on autopsy; however, their in vivo associations with atrophy across the continuum of Alzheimer's disease (AD) remain unclear.Methods: We estimated cortical thickness, tau ([18F]-AV-1451), and amyloid β (Aβ) status ([11C]-PiB) in 47 subjects who were stratified into Aβ- (14 healthy controls and six mild cognitive impairment-Aβ-) and Aβ+ (14 mild cognitive impairment-Aβ+ and 13 AD) groups.Results: Compared with the Aβ- group, tau was increased in widespread regions whereas cortical thinning was restricted to the temporal cortices. Increased tau binding was associated with cortical thinning in each Aβ group. Locally, regional tau was associated with temporoparietal atrophy.Discussion: These findings position tau as a promising therapeutic target. Further studies are needed to elucidate the casual relationships between tau pathology and trajectories of atrophy in AD.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Bethlehem, Richard A IDepartment of Psychiatry, University of Cambridge, Cambridge, UK (författare)
  • Romero-Garcia, RafaelDepartment of Psychiatry, University of Cambridge, Cambridge, UK (författare)
  • Cervenka, SimonKarolinska Institutet(Swepub:uu)simce160 (författare)
  • Rittman, TimothyDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, UK (författare)
  • Gabel, SilvyDepartment of Psychiatry, University of Cambridge, Cambridge, UK; Laboratory for Cognitive Neurology, University of Leuven, Leuven, Belgium (författare)
  • Surendranathan, AjenthanDepartment of Psychiatry, University of Cambridge, Cambridge, UK (författare)
  • Bevan-Jones, Richard WDepartment of Psychiatry, University of Cambridge, Cambridge, UK (författare)
  • Passamonti, LucaDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, UK (författare)
  • Vázquez Rodríguez, PatriciaDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, UK (författare)
  • Su, LiDepartment of Psychiatry, University of Cambridge, Cambridge, UK; China‐UK Centre for Cognition and Ageing Research, Southwest University, Chongqing, China (författare)
  • Arnold, RobertDepartment of Psychiatry, University of Cambridge, Cambridge, UK (författare)
  • Williams, Guy BWolfson Brain Imaging Centre, University of Cambridge, Cambridge, UK (författare)
  • Hong, Young TDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, UK; Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, UK (författare)
  • Fryer, Tim DDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, UK; Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, UK (författare)
  • Aigbirhio, Franklin IDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, UK; Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, UK (författare)
  • Rowe, James BMedical Research Council, and Brain Sciences Unit, Cambridge, UK; Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK (författare)
  • O'Brien, John TDepartment of Psychiatry, University of Cambridge, Cambridge, UK (författare)
  • Karolinska InstitutetDepartment of Psychiatry, University of Cambridge, Cambridge, UK (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Alzheimer's & dementia (Amsterdam, Netherlands): Wiley10, s. 678-6872352-8729

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