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Addition of lenalid...
Addition of lenalidomide to intensive treatment in younger and middle-aged adults with newly diagnosed AML : the HOVON-SAKK-132 trial
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- Löwenberg, Bob (author)
- Erasmus Univ Med Ctr MC, Rotterdam, Netherlands.;Erasmus MC Canc Inst, Rotterdam, Netherlands.
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- Pabst, Thomas (author)
- Inselspital Bern, Bern, Switzerland.
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- Maertens, Johan (author)
- Univ Hosp Gasthuisberg, Leuven, Belgium.
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- Gradowska, Patrycja (author)
- Erasmus MC Canc Inst, Dutch Belgian Hematooncol Cooperat Grp Data Ctr, Rotterdam, Netherlands.
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- Biemond, Bart J. (author)
- Amsterdam Univ Med Ctr, Amsterdam, Netherlands.
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- Spertini, Olivier (author)
- Univ Lausanne UNIL, Lausanne Univ Hosp, Ctr Hosp Univ Vaudois, Lausanne, Switzerland.
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- Vellenga, Edo (author)
- Univ Groningen, Univ Med Ctr, Groningen, Netherlands.
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- Griskevicius, Laimonas (author)
- Vilnius Univ Hosp, Santaros Klin, Vilnius, Lithuania.;Vilnius Univ, Vilnius, Lithuania.
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- Tick, Lidwine W. (author)
- Maxima Med Ctr, Eindhoven, Netherlands.
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- Jongen-Lavrencic, Mojca (author)
- Erasmus Univ Med Ctr MC, Rotterdam, Netherlands.;Erasmus MC Canc Inst, Rotterdam, Netherlands.
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- Kooy, Marinus van Marwijk (author)
- Isala Hosp, Zwolle, Netherlands.
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- Vekemans, Marie-Christiane (author)
- Univ Hosp St Luc, Brussels, Belgium.
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- van der Velden, Walter J. F. M. (author)
- Radboud Univ Nijmegen, Med Ctr, Nijmegen, Netherlands.
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- Beverloo, Berna (author)
- Erasmus Univ MC, Dept Clin Genet, Rotterdam, Netherlands.
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- Michaux, Lucienne (author)
- Katholieke Univ Leuven, Ctr Human Genet, Leuven, Belgium.;Univ Hosp Leuven, Leuven, Belgium.
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- Graux, Carlos (author)
- Univ Catholique Louvain Namur Godinne, Yvoir, Belgium.
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- Deeren, Dries (author)
- AZ Delta, Roeselare, Belgium.
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- de Weerdt, Okke (author)
- St Antonius Hosp, Nieuwegein, Netherlands.
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- van Esser, Joost W. J. (author)
- Amphia Hosp, Breda, Netherlands.
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- Bargetzi, Mario (author)
- Kantonsspittal, Aarau, Switzerland.
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- Klein, Saskia K. (author)
- Meander Med Ctr, Amersfoort, Netherlands.
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- Gadisseur, Alain (author)
- Univ Hosp Antwerpen, Edegem, Belgium.
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- Westerweel, Peter E. (author)
- Albert Schweitzer Hosp, Dordrecht, Netherlands.
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- Veelken, Hendrik (author)
- Univ Med Ctr, Leiden, Netherlands.
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- Gregor, Michael (author)
- Luzerner Kantonsspittal, Luzern, Switzerland.
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- Silzle, Tobias (author)
- Kantonsspittal, St Gallen, Switzerland.
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- Van Lammeren-Venema, Danielle (author)
- Haga Hosp, The Hague, Netherlands.
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- Moors, Ine (author)
- Univ Hosp, Ghent, Belgium.
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- Breems, Dimitri A. (author)
- Ziekenhuis Netwerk Antwerpen, Antwerp, Belgium.
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- Hoogendoorn, Mels (author)
- Med Spectrum Leeuwarden, Leeuwarden, Netherlands.
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- Legdeur, Marie-Cecile J. C. (author)
- Med Spectrum Twente, Enschede, Netherlands.
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- Fischer, Thomas (author)
- Otto von Guericke Univ Hosp Magdeburg, Magdeburg, Germany.
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- Kuball, Juergen (author)
- Univ Med Ctr Utrecht, Utrecht, Netherlands.
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- Cornelissen, Jan (author)
- Erasmus Univ Med Ctr MC, Rotterdam, Netherlands.;Erasmus MC Canc Inst, Rotterdam, Netherlands.
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- Porkka, Kimmo (author)
- Helsinki Univ Hosp Canc Ctr, Helsinki, Finland.
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- Juliusson, Gunnar (author)
- Skanes Univ Hosp, Lund, Sweden.
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- Meyer, Peter (author)
- Stavanger Univ Hosp Rogaland, Stavanger, Norway.
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- Höglund, Martin (author)
- Uppsala universitet,Hematologi
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- Gjertsen, Bjorn T. (author)
- Haukeland Hosp, Bergen, Norway.
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- Janssen, Jeroen J. W. M. (author)
- Amsterdam Vrije Univ, Med Ctr, Amsterdam, Netherlands.
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- Huls, Gerwin (author)
- Univ Groningen, Univ Med Ctr, Groningen, Netherlands.
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- Passweg, Jakob (author)
- Univ Hosp, Basel, Switzerland.
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- Cloos, Jacqueline (author)
- Amsterdam Vrije Univ, Med Ctr, Amsterdam, Netherlands.
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- Valk, Peter J. M. (author)
- Erasmus Univ Med Ctr MC, Rotterdam, Netherlands.;Erasmus MC Canc Inst, Rotterdam, Netherlands.
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- van Elssen, Catharina H. M. J. (author)
- Univ Med Ctr, Maastricht, Netherlands.
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- Manz, Markus G. (author)
- Univ Hosp, Zurich, Switzerland.
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- Floisand, Yngvar (author)
- Oslo Univ Hosp, Oslo, Norway.
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- Ossenkoppele, Gert J. (author)
- Amsterdam Vrije Univ, Med Ctr, Amsterdam, Netherlands.
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Erasmus Univ Med Ctr MC, Rotterdam, Netherlands;Erasmus MC Canc Inst, Rotterdam, Netherlands. Inselspital Bern, Bern, Switzerland. (creator_code:org_t)
- 2021-02-22
- 2021
- English.
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In: Blood Advances. - : American Society of Hematology. - 2473-9529 .- 2473-9537. ; 5:4, s. 1110-1121
- Related links:
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https://ashpublicati...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Lenalidomide, an antineoplastic and immunomodulatory drug, has therapeutic activity in acute myeloid leukemia (AML), but definitive studies about its therapeutic utility have been lacking. In a phase 3 study, we compared 2 induction regimens in newly diagnosed patients age 18 to 65 years with AML: idarubicine-cytarabine (cycle 1) and daunorubicin and intermediate-dose cytarabine (cycle 2) without or with lenalidomide (15 mg orally on days 1-21). One final consolidation cycle of chemotherapy or autologous stem cell transplantation (auto-SCT) or allogeneic SCT (allo-SCT) was provided according to a prognostic risk and minimal residual disease (MRD)-adapted approach. Event-free survival (EFS; primary end point) and other clinical end points were assessed. A second random assignment in patients in complete response or in complete response with incomplete hematologic recovery after cycle 3 or auto-SCT involved 6 cycles of maintenance with lenalidomide (10 mg on days 1-21) or observation. In all, 392 patients were randomly assigned to the control group, and 388 patients were randomly assigned to lenalidomide induction. At a median follow-up of 41 months, the study revealed no differences in outcome between the treatments (EFS, 44% +/- 2% standard error and overall survival, 54% = 2% at 4 years for both arms) although in an exploratory post hoc analysis, a lenalidomide benefit was suggested in SRSF2-mutant AML. In relation to the previous Dutch-Belgian Hemato-Oncology Cooperative Group and Swiss Group for Clinical Cancer Research (HOVON-SAKK) studies that used a similar 3-cycle regimen but did not pursue an MRD-guided approach, these survival estimates compare markedly more favorably. MRD status after cycle 2 lost prognostic value in intermediate-risk AML in the risk-adjusted treatment context. Maintenance with lenalidomide showed no apparent effect on relapse probability in 88 patients randomly assigned for this part of the study.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Löwenberg, Bob
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Pabst, Thomas
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Maertens, Johan
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Gradowska, Patry ...
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Biemond, Bart J.
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Spertini, Olivie ...
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show more...
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Vellenga, Edo
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Griskevicius, La ...
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Tick, Lidwine W.
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Jongen-Lavrencic ...
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Kooy, Marinus va ...
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Vekemans, Marie- ...
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van der Velden, ...
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Beverloo, Berna
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Michaux, Lucienn ...
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Graux, Carlos
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Deeren, Dries
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de Weerdt, Okke
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van Esser, Joost ...
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Bargetzi, Mario
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Klein, Saskia K.
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Gadisseur, Alain
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Westerweel, Pete ...
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Veelken, Hendrik
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Gregor, Michael
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Silzle, Tobias
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Van Lammeren-Ven ...
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Moors, Ine
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Breems, Dimitri ...
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Hoogendoorn, Mel ...
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Legdeur, Marie-C ...
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Fischer, Thomas
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Kuball, Juergen
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Cornelissen, Jan
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Porkka, Kimmo
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Juliusson, Gunna ...
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Meyer, Peter
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Höglund, Martin
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Gjertsen, Bjorn ...
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Janssen, Jeroen ...
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Huls, Gerwin
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Passweg, Jakob
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Cloos, Jacquelin ...
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Valk, Peter J. M ...
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van Elssen, Cath ...
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Manz, Markus G.
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Floisand, Yngvar
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Ossenkoppele, Ge ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
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MEDICAL AND HEAL ...
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- Articles in the publication
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Blood Advances
- By the university
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Uppsala University