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Oral characteristic...
Oral characteristics in adult individuals with periodontal Ehlers-Danlos syndrome
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- Lepperdinger, Ulrike (författare)
- Department of Operative and Restorative Dentistry, Medical University of Innsbruck, Innsbruck, Austria
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- Angwin, Chloe (författare)
- National Ehlers Danlos Syndrome Service, London North West University Healthcare NHS Trust, London, United Kingdom; Department of Metabolism, Digestion and Reproduction, Section of Genetics and Genomics, Imperial College London, London, United Kingdom
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- Milnes, Di (författare)
- Genetic Health Queensland, Royal Brisbane and Women's Hospital, QLD, Herston, Australia
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- Sobey, Glenda (författare)
- Ehlers Danlos Syndrome National Diagnostic Service, Sheffield Children's Hospital, Sheffield, United Kingdom
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- Ghali, Neeti (författare)
- National Ehlers Danlos Syndrome Service, London North West University Healthcare NHS Trust, London, United Kingdom; Department of Metabolism, Digestion and Reproduction, Section of Genetics and Genomics, Imperial College London, London, United Kingdom
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- Johnson, Diana (författare)
- Ehlers Danlos Syndrome National Diagnostic Service, Sheffield Children's Hospital, Sheffield, United Kingdom
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- Brady, Angela F. (författare)
- National Ehlers Danlos Syndrome Service, London North West University Healthcare NHS Trust, London, United Kingdom; Department of Metabolism, Digestion and Reproduction, Section of Genetics and Genomics, Imperial College London, London, United Kingdom
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- Kammin, Tammy (författare)
- Ehlers Danlos Syndrome National Diagnostic Service, Sheffield Children's Hospital, Sheffield, United Kingdom
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- Bowen, Jessica M. (författare)
- Ehlers Danlos Syndrome National Diagnostic Service, Sheffield Children's Hospital, Sheffield, United Kingdom
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- Gröbner, Rebekka (författare)
- Institute of Human Genetics, Medical University of Innsbruck, Innsbruck, Austria
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- Lundberg, Pernilla, 1965- (författare)
- Umeå universitet,Institutionen för odontologi
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- Scott, James (författare)
- Academic Unit of Restorative Dentistry, Sheffield University, Sheffield, United Kingdom
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- Zschocke, Johannes (författare)
- Institute of Human Genetics, Medical University of Innsbruck, Innsbruck, Austria
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- van Dijk, Fleur S. (författare)
- National Ehlers Danlos Syndrome Service, London North West University Healthcare NHS Trust, London, United Kingdom; Department of Metabolism, Digestion and Reproduction, Section of Genetics and Genomics, Imperial College London, London, United Kingdom
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- Kapferer-Seebacher, Ines (författare)
- Department of Operative and Restorative Dentistry, Medical University of Innsbruck, Innsbruck, Austria
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(creator_code:org_t)
- 2022-07-29
- 2022
- Engelska.
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Ingår i: Journal of Clinical Periodontology. - : John Wiley & Sons. - 0303-6979 .- 1600-051X. ; 49:12, s. 1244-1252
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Aim: Periodontal Ehlers-Danlos syndrome (pEDS) is a monogenic type of Ehlers-Danlos syndrome characterized by periodontal destruction at a young age. The present study aimed to document the oral phenotype of pEDS based on prospective clinical investigations.Materials and Methods: Thirty-five adult individuals from 13 families with a clinically and genetically confirmed diagnosis of pEDS underwent a systematic oral assessment.Results: Periodontitis stage 3 or 4 or edentulism due to periodontal destruction were diagnosed in 94% of the individuals. First permanent tooth loss was reported at the age of 21.5 years (median; range 13–43 years). Deep periodontal pockets were infrequent, with 94% measuring <4 mm. However, there was increased clinical attachment loss (CAL) averaging 8 mm (range 4–13 mm), and the probability of being edentate between the age of 35 and 44 years was 28–47% compared with less than 0.25% of the general population. Radiographic anomalous findings were only found in a portion of subjects and consisted of fused roots of maxillary second molars (81%), root hypoplasia (57%), taurodontism (26%) and tooth rotation of premolars (67%). As such, radiographic findings are not considered common characteristics of pEDS.Conclusions: Characteristic oral traits of pEDS in adults are severe CAL with shallow probing depths and marked gingival recession. This is complemented by a lack of attached gingiva. These indications need to be paralleled by genetic analyses to diagnose pEDS unambiguously.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
Nyckelord
- attached gingiva
- C1R
- C1S
- Ehlers-Danlos syndrome
- periodontitis
- odontologi
- Odontology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Lepperdinger, Ul ...
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Angwin, Chloe
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Milnes, Di
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Sobey, Glenda
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Ghali, Neeti
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Johnson, Diana
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visa fler...
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Brady, Angela F.
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Kammin, Tammy
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Bowen, Jessica M ...
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Gröbner, Rebekka
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Lundberg, Pernil ...
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Scott, James
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Zschocke, Johann ...
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van Dijk, Fleur ...
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Kapferer-Seebach ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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Umeå universitet