WFRF:(Zhu Zhenyu)
Sökning: WFRF:(Zhu Zhenyu) > (2020-2024) > Absorption and tran...
Absorption and transport of a Mytilus edulis-derived peptide with the function of preventing osteoporosis
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- Xu, Zhe (författare)
- Dalian Polytech Univ, Collaborat Innovat Ctr Seafood Deep Proc, Natl Engn Res Ctr Seafood, Sch Food Sci & Technol, Dalian 116034, Peoples R China.;Dalian Minzu Univ, Minist Educ, Coll Life Sci, Key Lab Biotechnol & Bioresources Utilizat, Dalian 116029, Peoples R China.
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- Fan, Fengjiao (författare)
- Nanjing Univ Finance & Econ, Coll Food Sci & Engn, Nanjing 210046, Peoples R China.
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- Chen, Hui (författare)
- Zhejiang Univ Technol, Coll Food Sci & Technol, Hangzhou 310014, Peoples R China.
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- Dalian Polytech Univ, Collaborat Innovat Ctr Seafood Deep Proc, Natl Engn Res Ctr Seafood, Sch Food Sci & Technol, Dalian 116034, Peoples R China;Dalian Minzu Univ, Minist Educ, Coll Life Sci, Key Lab Biotechnol & Bioresources Utilizat, Dalian 116029, Peoples R China. Nanjing Univ Finance & Econ, Coll Food Sci & Engn, Nanjing 210046, Peoples R China. (creator_code:org_t)
- 2021
- 2021
- Engelska.
- Ingår i: Food & Function. - : Royal Society of Chemistry. - 2042-6496 .- 2042-650X. ; 12:5, s. 2102-2111
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- The YPRKDETGAERT peptide (PME-1) identified from the Mytilus edulis proteins has been shown to promote the proliferation and differentiation of osteoblasts and it has good bone-forming activity in vitro. Further, PME-1 has been shown to prevent osteoporosis in vivo. PME-1 can be absorbed through the gastrointestinal tract, and the passing rate in monolayer Caco-2 cells was 6.57%. PME-1 can also enter the blood circulation and the concentration of PME-1 in serum reached the maximum, 61.06 +/- 26.32 ng mL(-1), 20 min after feeding. The multifunctional in vivo imager was used to further determine the distribution of the 5-FITC-(Acp)-YPRKDETGAERT peptide (PME-1-FITC) 2 h after feeding the peptide, and the result confirmed the above results and showed that a part of PME-1-FITC can affect bone in vivo. Therefore, PME-1 not only was easily absorbed in the gastrointestinal tract, but also has the potential beneficial effect on preventing osteoporosis.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
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- Xu, Zhe
- Fan, Fengjiao
- Chen, Hui
- Shi, Pujie
- Zhu, Dongyang
- Yang, Meilian
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- Wang, Zhenyu
- El-Seedi, Hesham
- Du, Ming
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