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Supplementation wit...
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Albert, Benjamin B.Univ Auckland, Liggins Inst, Auckland, New Zealand.
(författare)
Supplementation with milk enriched with complex lipids during pregnancy : A double-blind randomized controlled trial
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
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2021-02-24
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Public Library of Science (PLoS),2021
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electronicrdacarrier
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LIBRIS-ID:oai:DiVA.org:uu-441634
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-441634URI
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https://doi.org/10.1371/journal.pone.0244916DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Background Gangliosides are a class of sphingolipids that are present in the cell membranes of vertebrates. Gangliosides influence a broad range of cellular processes through effects on signal transduction, being found abundantly in the brain, and having a role in neurodevelopment.Objective We aimed to assess the effects of maternal daily consumption of ganglioside-enriched milk vs non-enriched milk and a non-supplemented group of pregnant women on maternal ganglioside levels and pregnancy outcomes.Design Double-blind parallel randomized controlled trial. Methods 1,500 women aged 20-40 years were recruited in Chongqing (China) between 11 and 14 weeks of a singleton pregnancy, and randomized into three groups: Control-received standard powdered milk formulation (>= 4 mg gangliosides/day); Complex milk lipid-enhanced (CML-E) group-same formulation enriched with complex milk lipids (>= 8 mg gangliosides/day) from milk fat globule membrane; Reference-received no milk. Serum ganglioside levels were measured in a randomly selected subsample of 250 women per group.Results CML-E milk was associated with marginally greater total gangliosides levels in maternal serum compared to Control (13.02 vs 12.69 mu g/ml; p = 0.034) but not to Reference group. CML-E milk did not affect cord blood ganglioside levels. Among the 1500 women, CML-E milk consumption was associated with a lower rate of gestational diabetes mellitus than control milk [relative risk 0.80 (95% CI 0.64, 0.99)], but which was not different to the Reference group. CML-E milk supplementation had no other effects on maternal or newborn health.Conclusions Maternal supplementation with milk fat globule membrane, as a source of gangliosides, was not associated with any adverse health outcomes, and did not increase serum gangliosides compared with the non-supplemented reference group.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Derraik, José G. B.Uppsala universitet,Perinatal, neonatal och barnkardiologisk forskning,Univ Auckland, Liggins Inst, Auckland, New Zealand(Swepub:uu)josde820
(författare)
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Xia, Yin-YinChongqing Med Univ, Innovat Ctr Social Risk Governance Hlth, Res Ctr Med & Social Dev, Sch Publ Hlth & Management, Chongqing, Peoples R China.
(författare)
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Norris, TomUniv Leicester, Coll Life Sci, Leicester, Leics, England.
(författare)
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Zhang, TingChongqing Med Univ, Affiliated Hosp 1, Dept Obstet & Gynaecol, Chongqing, Peoples R China.
(författare)
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Han, Ting-LiChongqing Med Univ, Affiliated Hosp 1, Dept Obstet & Gynaecol, Chongqing, Peoples R China.;Chongqing Med Univ, Canada China New Zealand Joint Lab Maternal & Fet, Chongqing, Peoples R China.
(författare)
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Chang, ChenChongqing Med Univ, Affiliated Hosp 1, Dept Obstet & Gynaecol, Chongqing, Peoples R China.;Chongqing Med Univ, Canada China New Zealand Joint Lab Maternal & Fet, Chongqing, Peoples R China.
(författare)
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Rowan, AngelaFonterra Cooperat Grp Ltd, Palmerston North, New Zealand.
(författare)
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Gallier, SophieFonterra Cooperat Grp Ltd, Palmerston North, New Zealand.
(författare)
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Souza, Renato T.Univ Estadual Campinas, Dept Obstet & Gynaecol, Campinas, Brazil.
(författare)
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Hammond, Judith J.Auckland UniServ Ltd, Auckland, New Zealand.
(författare)
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Zhou, WeiChongqing Hlth Ctr Women & Children, Dept Obstet, Chongqing, Peoples R China.
(författare)
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Zhang, HuaChongqing Med Univ, Affiliated Hosp 1, Dept Obstet & Gynaecol, Chongqing, Peoples R China.;Chongqing Med Univ, Canada China New Zealand Joint Lab Maternal & Fet, Chongqing, Peoples R China.
(författare)
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Qi, Hong-BoChongqing Med Univ, Affiliated Hosp 1, Dept Obstet & Gynaecol, Chongqing, Peoples R China.;Chongqing Med Univ, Canada China New Zealand Joint Lab Maternal & Fet, Chongqing, Peoples R China.
(författare)
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Baker, Philip N.Chongqing Med Univ, Affiliated Hosp 1, Dept Obstet & Gynaecol, Chongqing, Peoples R China.;Chongqing Med Univ, Canada China New Zealand Joint Lab Maternal & Fet, Chongqing, Peoples R China.
(författare)
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Univ Auckland, Liggins Inst, Auckland, New Zealand.Perinatal, neonatal och barnkardiologisk forskning
(creator_code:org_t)
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Ingår i:PLOS ONE: Public Library of Science (PLoS)16:21932-6203
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Albert, Benjamin ...
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Derraik, José G. ...
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Xia, Yin-Yin
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Norris, Tom
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Zhang, Ting
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Han, Ting-Li
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Chang, Chen
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Rowan, Angela
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Gallier, Sophie
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Souza, Renato T.
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Hammond, Judith ...
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Zhou, Wei
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Zhang, Hua
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Qi, Hong-Bo
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Baker, Philip N.
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