SwePub
Sök i LIBRIS databas

  Utökad sökning

id:"swepub:oai:DiVA.org:uu-441634"
 

Sökning: id:"swepub:oai:DiVA.org:uu-441634" > Supplementation wit...

  • Albert, Benjamin B.Univ Auckland, Liggins Inst, Auckland, New Zealand. (författare)

Supplementation with milk enriched with complex lipids during pregnancy : A double-blind randomized controlled trial

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • 2021-02-24
  • Public Library of Science (PLoS),2021
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-441634
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-441634URI
  • https://doi.org/10.1371/journal.pone.0244916DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background Gangliosides are a class of sphingolipids that are present in the cell membranes of vertebrates. Gangliosides influence a broad range of cellular processes through effects on signal transduction, being found abundantly in the brain, and having a role in neurodevelopment.Objective We aimed to assess the effects of maternal daily consumption of ganglioside-enriched milk vs non-enriched milk and a non-supplemented group of pregnant women on maternal ganglioside levels and pregnancy outcomes.Design Double-blind parallel randomized controlled trial. Methods 1,500 women aged 20-40 years were recruited in Chongqing (China) between 11 and 14 weeks of a singleton pregnancy, and randomized into three groups: Control-received standard powdered milk formulation (>= 4 mg gangliosides/day); Complex milk lipid-enhanced (CML-E) group-same formulation enriched with complex milk lipids (>= 8 mg gangliosides/day) from milk fat globule membrane; Reference-received no milk. Serum ganglioside levels were measured in a randomly selected subsample of 250 women per group.Results CML-E milk was associated with marginally greater total gangliosides levels in maternal serum compared to Control (13.02 vs 12.69 mu g/ml; p = 0.034) but not to Reference group. CML-E milk did not affect cord blood ganglioside levels. Among the 1500 women, CML-E milk consumption was associated with a lower rate of gestational diabetes mellitus than control milk [relative risk 0.80 (95% CI 0.64, 0.99)], but which was not different to the Reference group. CML-E milk supplementation had no other effects on maternal or newborn health.Conclusions Maternal supplementation with milk fat globule membrane, as a source of gangliosides, was not associated with any adverse health outcomes, and did not increase serum gangliosides compared with the non-supplemented reference group.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Derraik, José G. B.Uppsala universitet,Perinatal, neonatal och barnkardiologisk forskning,Univ Auckland, Liggins Inst, Auckland, New Zealand(Swepub:uu)josde820 (författare)
  • Xia, Yin-YinChongqing Med Univ, Innovat Ctr Social Risk Governance Hlth, Res Ctr Med & Social Dev, Sch Publ Hlth & Management, Chongqing, Peoples R China. (författare)
  • Norris, TomUniv Leicester, Coll Life Sci, Leicester, Leics, England. (författare)
  • Zhang, TingChongqing Med Univ, Affiliated Hosp 1, Dept Obstet & Gynaecol, Chongqing, Peoples R China. (författare)
  • Han, Ting-LiChongqing Med Univ, Affiliated Hosp 1, Dept Obstet & Gynaecol, Chongqing, Peoples R China.;Chongqing Med Univ, Canada China New Zealand Joint Lab Maternal & Fet, Chongqing, Peoples R China. (författare)
  • Chang, ChenChongqing Med Univ, Affiliated Hosp 1, Dept Obstet & Gynaecol, Chongqing, Peoples R China.;Chongqing Med Univ, Canada China New Zealand Joint Lab Maternal & Fet, Chongqing, Peoples R China. (författare)
  • Rowan, AngelaFonterra Cooperat Grp Ltd, Palmerston North, New Zealand. (författare)
  • Gallier, SophieFonterra Cooperat Grp Ltd, Palmerston North, New Zealand. (författare)
  • Souza, Renato T.Univ Estadual Campinas, Dept Obstet & Gynaecol, Campinas, Brazil. (författare)
  • Hammond, Judith J.Auckland UniServ Ltd, Auckland, New Zealand. (författare)
  • Zhou, WeiChongqing Hlth Ctr Women & Children, Dept Obstet, Chongqing, Peoples R China. (författare)
  • Zhang, HuaChongqing Med Univ, Affiliated Hosp 1, Dept Obstet & Gynaecol, Chongqing, Peoples R China.;Chongqing Med Univ, Canada China New Zealand Joint Lab Maternal & Fet, Chongqing, Peoples R China. (författare)
  • Qi, Hong-BoChongqing Med Univ, Affiliated Hosp 1, Dept Obstet & Gynaecol, Chongqing, Peoples R China.;Chongqing Med Univ, Canada China New Zealand Joint Lab Maternal & Fet, Chongqing, Peoples R China. (författare)
  • Baker, Philip N.Chongqing Med Univ, Affiliated Hosp 1, Dept Obstet & Gynaecol, Chongqing, Peoples R China.;Chongqing Med Univ, Canada China New Zealand Joint Lab Maternal & Fet, Chongqing, Peoples R China. (författare)
  • Univ Auckland, Liggins Inst, Auckland, New Zealand.Perinatal, neonatal och barnkardiologisk forskning (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:PLOS ONE: Public Library of Science (PLoS)16:21932-6203

Internetlänk

Hitta via bibliotek

  • PLOS ONE (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy