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Differences in the ...
Differences in the Microbial Composition of Hemodialysis Patients Treated with and without β-Blockers
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- Lin, Yi-Ting (författare)
- Kaohsiung Med Univ Hosp, Dept Family Med, Kaohsiung 80708, Taiwan; Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung 80708, Taiwan; Kaohsiung Med Univ, Grad Inst Clin Med, Coll Med, Kaohsiung 80708, Taiwan
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- Lin, Ting-Yun (författare)
- Taipei Tzu Chi Hosp, Div Nephrol, Buddhist Tzu Chi Med Fdn, New Taipei 23142, Taiwan; Tzu Chi Univ, Sch Med, Hualien 97071, Taiwan
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- Hung, Szu-Chun (författare)
- Taipei Tzu Chi Hosp, Div Nephrol, Buddhist Tzu Chi Med Fdn, New Taipei 23142, Taiwan; Tzu Chi Univ, Sch Med, Hualien 97071, Taiwan
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- Liu, Po-Yu (författare)
- Natl Taiwan Univ, Dept Internal Med, Coll Med, Taipei 100225, Taiwan
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- Hung, Wei-Chun (författare)
- Kaohsiung Med Univ, Dept Microbiol & Immunol, Kaohsiung 80708, Taiwan
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- Tsai, Wei-Chung (författare)
- Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Cardiol, Kaohsiung 80708, Taiwan
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- Tsai, Yi-Chun (författare)
- Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung 80708, Taiwan; Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Div Gen Med, Kaohsiung 80708, Taiwan; Kaohsiung Med Univ, Fac Renal Care, Coll Med, Kaohsiung 80708, Taiwan
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- Delicano, Rachel Ann (författare)
- Uppsala universitet,Ortopedi
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- Chuang, Yun-Shiuan (författare)
- Kaohsiung Med Univ Hosp, Dept Family Med, Kaohsiung 80708, Taiwan
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- Kuo, Mei-Chuan (författare)
- Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung 80708, Taiwan; Kaohsiung Med Univ, Fac Renal Care, Coll Med, Kaohsiung 80708, Taiwan; Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, Kaohsiung 80708, Taiwan
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- Chiu, Yi-Wen (författare)
- Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung 80708, Taiwan; Kaohsiung Med Univ, Fac Renal Care, Coll Med, Kaohsiung 80708, Taiwan; Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, Kaohsiung 80708, Taiwan
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- Wu, Ping-Hsun (författare)
- Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung 80708, Taiwan; Kaohsiung Med Univ, Grad Inst Clin Med, Coll Med, Kaohsiung 80708, Taiwan; Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, Kaohsiung 80708, Taiwan
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(creator_code:org_t)
- 2021-03-12
- 2021
- Engelska.
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Ingår i: Journal of Personalized Medicine. - : MDPI. - 2075-4426. ; 11:3
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://www.mdpi.com...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- β-blockers are commonly prescribed to treat cardiovascular disease in hemodialysis patients. Beyond the pharmacological effects, β-blockers have potential impacts on gut microbiota, but no study has investigated the effect in hemodialysis patients. Hence, we aim to investigate the gut microbiota composition difference between β-blocker users and nonusers in hemodialysis patients. Fecal samples collected from hemodialysis patients (83 β-blocker users and 110 nonusers) were determined by 16S ribosomal RNA amplification sequencing. Propensity score (PS) matching was performed to control confounders. The microbial composition differences were analyzed by the linear discriminant analysis effect size, random forest, and zero-inflated Gaussian fit model. The α-diversity (Simpson index) was greater in β-blocker users with a distinct β-diversity (Bray–Curtis Index) compared to nonusers in both full and PS-matched cohorts. There was a significant enrichment in the genus Flavonifractor in β-blocker users compared to nonusers in full and PS-matched cohorts. A similar finding was demonstrated in random forest analysis. In conclusion, hemodialysis patients using β-blockers had a different gut microbiota composition compared to nonusers. In particular, the Flavonifractor genus was increased with β-blocker treatment. Our findings highlight the impact of β-blockers on the gut microbiota in hemodialysis patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Nyckelord
- microbiome
- beta-blocker
- hemodialysis
- next-generation sequencing
- propensity score matching methods
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Lin, Yi-Ting
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Lin, Ting-Yun
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Hung, Szu-Chun
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Liu, Po-Yu
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Hung, Wei-Chun
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Tsai, Wei-Chung
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Tsai, Yi-Chun
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Delicano, Rachel ...
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Chuang, Yun-Shiu ...
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Kuo, Mei-Chuan
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Chiu, Yi-Wen
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Wu, Ping-Hsun
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Uppsala universitet