Associations of ultrasound estimated early mid pregnancy visceral and subcutaneous fat depths and early pregnancy BMI with adverse neonatal outcomes

Lindberger, EmelieUppsala universitet,Perinatal, neonatal och barnkardiologisk forskning (author)

This study investigated whether maternal central adiposity and body mass index (BMI) were associated with neonatal hypoglycemia and adverse neonatal outcomes. A cohort study was performed at Uppsala University Hospital, Sweden, between 2015 and 2018. Visceral and subcutaneous fat depths were measured by ultrasound at the early second-trimester anomaly scan in 2771 women giving birth to singleton infants. Body mass index was assessed in early pregnancy. Logistic regression models were performed. Adjustments were made for age, BMI (not in model with BMI as exposure), smoking, maternal country of birth, and parity. Outcomes were neonatal hypoglycemia (blood glucose concentration < 2.6 mmol/l), a composite of adverse neonatal outcomes (Apgar < 7 at 5 min of age, or umbilical artery pH ≤ 7.0, or admission to neonatal intensive care unit), and the components of the composite outcome. Visceral and subcutaneous fat depths measured by ultrasound in early mid pregnancy were not associated with any of the outcomes in adjusted analyses. For every unit increase in BMI, the likelihood of neonatal hypoglycemia increased by 5% (aOR 1.05, 95% CI 1.01–1.10), the composite outcome by 5% (aOR 1.05, 95% CI 1.01–1.08), and admission to neonatal intensive care unit by 6% (aOR 1.06, 95% CI 1.02–1.10).

Wikström, Anna-Karin,1965-Uppsala universitet,Klinisk obstetrik(Swepub:uu)annwi179 (author)
Bergman, Eva,1959-Uppsala universitet,Obstetrisk och reproduktiv hälsoforskning(Swepub:uu)evber534 (author)
Eurenius, Karin,1951-Uppsala universitet,Obstetrisk och reproduktiv hälsoforskning(Swepub:uu)kaeur030 (author)
Mulic-Lutvica, Ajlana,1957-Uppsala universitet,Obstetrisk och reproduktiv hälsoforskning(Swepub:uu)ajlut120 (author)
Lindström, Linda,1978-Uppsala universitet,Klinisk obstetrik(Swepub:uu)linli329 (author)
Sundström Poromaa, Inger,1964-Uppsala universitet,Reproduktiv hälsa(Swepub:uu)inspo702 (author)
Ahlsson, Fredrik,1967-Uppsala universitet,Perinatal, neonatal och barnkardiologisk forskning(Swepub:uu)fredahls (author)
Uppsala universitetPerinatal, neonatal och barnkardiologisk forskning (creator_code:org_t)

By the author/editor: Lindberger, Emel ...; Wikström, Anna-K ...; Bergman, Eva, 19 ...; Eurenius, Karin, ...; Mulic-Lutvica, A ...; Lindström, Linda ...; show more...; Sundström Poroma ...; Ahlsson, Fredrik ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Pediatrics

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Obstetrics Gynae ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Endocrinology an ...

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