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Genetic substructure and complex demographic history of South African Bantu speakers

Sengupta, Dhriti (author)
Univ Witwatersrand, Sydney Brenner Inst Mol Biosci, Fac Hlth Sci, Johannesburg, South Africa.
Choudhury, Ananyo (author)
Univ Witwatersrand, Sydney Brenner Inst Mol Biosci, Fac Hlth Sci, Johannesburg, South Africa.
Fortes-Lima, Cesar A. (author)
Uppsala universitet,Människans evolution
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Aron, Shaun (author)
Univ Witwatersrand, Sydney Brenner Inst Mol Biosci, Fac Hlth Sci, Johannesburg, South Africa.
Whitelaw, Gavin (author)
KwaZulu Natal Museum, Pietermaritzburg, South Africa.;Univ Witwatersrand, Sch Geog Archaeol & Environm Studies, Johannesburg, South Africa.
Bostoen, Koen (author)
Univ Ghent, Dept Languages & Cultures, UGent Ctr Bantu Studies, Ghent, Belgium.;Univ Zurich, Dept Comparat Linguist Sci, Zurich, Switzerland.
Gunnink, Hilde (author)
Univ Ghent, Dept Languages & Cultures, UGent Ctr Bantu Studies, Ghent, Belgium.;Univ Zurich, Dept Comparat Linguist Sci, Zurich, Switzerland.
Chousou-Polydouri, Natalia (author)
Univ Zurich, Ctr Interdisciplinary Study Language Evolut, Zurich, Switzerland.
Delius, Peter (author)
Univ Witwatersrand, Dept Hist, Johannesburg, South Africa.
Tollman, Stephen (author)
Univ Witwatersrand, MRC Wits Rural Publ Hlth & Hlth Transit Res Unit, Sch Publ Hlth, Fac Hlth Sci, Johannesburg, South Africa.
Gomez-Olive, F. Xavier (author)
Univ Witwatersrand, MRC Wits Rural Publ Hlth & Hlth Transit Res Unit, Sch Publ Hlth, Fac Hlth Sci, Johannesburg, South Africa.
Norris, Shane (author)
Univ Witwatersrand, MRC Wits Dev Pathways Hlth Res Unit, Fac Hlth Sci, Johannesburg, South Africa.
Mashinya, Felistas (author)
Univ Limpopo, Dept Pathol & Med Sci, Sch Hlth Care Sci, Fac Hlth Sci, Polokwane, South Africa.
Alberts, Marianne (author)
Univ Limpopo, Dept Pathol & Med Sci, Sch Hlth Care Sci, Fac Hlth Sci, Polokwane, South Africa.
Hazelhurst, Scott (author)
Univ Witwatersrand, Sydney Brenner Inst Mol Biosci, Fac Hlth Sci, Johannesburg, South Africa.;Univ Witwatersrand, Sch Elect & Informat Engn, Johannesburg, South Africa.
Schlebusch, Carina, 1977- (author)
Uppsala universitet,Människans evolution,Science for Life Laboratory, SciLifeLab,Univ Johannesburg, Palaeores Inst, Johannesburg, South Africa.
Ramsay, Michele (author)
Univ Witwatersrand, Sydney Brenner Inst Mol Biosci, Fac Hlth Sci, Johannesburg, South Africa.;Univ Witwatersrand, Div Human Genet, Natl Hlth Lab Serv, Johannesburg, South Africa.;Univ Witwatersrand, Sch Pathol, Fac Hlth Sci, Johannesburg, South Africa.
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Univ Witwatersrand, Sydney Brenner Inst Mol Biosci, Fac Hlth Sci, Johannesburg, South Africa Människans evolution (creator_code:org_t)
2021-04-07
2021
English.
In: Nature Communications. - : Springer Nature. - 2041-1723. ; 12:1
Related links:
https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
https://www.nature.c...
https://urn.kb.se/re...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • South Eastern Bantu-speaking (SEB) groups constitute more than 80% of the population in South Africa. Despite clear linguistic and geographic diversity, the genetic differences between these groups have not been systematically investigated. Based on genome-wide data of over 5000 individuals, representing eight major SEB groups, we provide strong evidence for fine-scale population structure that broadly aligns with geographic distribution and is also congruent with linguistic phylogeny (separation of Nguni, Sotho-Tswana and Tsonga speakers). Although differential Khoe-San admixture plays a key role, the structure persists after Khoe-San ancestry-masking. The timing of admixture, levels of sex-biased gene flow and population size dynamics also highlight differences in the demographic histories of individual groups. The comparisons with five Iron Age farmer genomes further support genetic continuity over similar to 400 years in certain regions of the country. Simulated trait genome-wide association studies further show that the observed population structure could have major implications for biomedical genomics research in South Africa. Despite linguistic and geographic diversity in South Eastern Bantu-speaking (SEB) groups of South Africa, genetic variation in these groups has not been investigated in depth. Here, the authors analyse genome-wide data from 5056 individuals, providing insights into demographic history across SEB groups.

Subject headings

NATURVETENSKAP  -- Biologi -- Genetik (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Genetics (hsv//eng)
NATURVETENSKAP  -- Biologi -- Evolutionsbiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Evolutionary Biology (hsv//eng)

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