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Mortality outcomes ...
Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials
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- Axfors, Cathrine (författare)
- Uppsala universitet,Obstetrisk och reproduktiv hälsoforskning,Stanford Univ, Meta Res Innovat Ctr Stanford METRICS, Stanford, CA 94305 USA.
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- Schmitt, Andreas M. (författare)
- Univ Basel, Univ Hosp Basel, Dept Clin Res, Basel, Switzerland.;Univ Basel, Dept Med Oncol, Basel, Switzerland.
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- Janiaud, Perrine (författare)
- Univ Basel, Univ Hosp Basel, Dept Clin Res, Basel, Switzerland.
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visa fler...
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- van't Hooft, Janneke (författare)
- Stanford Univ, Meta Res Innovat Ctr Stanford METRICS, Stanford, CA 94305 USA.;Univ Amsterdam, Amsterdam Univ Med Ctr, Amsterdam, Netherlands.
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- Abd-Elsalam, Sherief (författare)
- Tanta Univ, Fac Med, Trop Med & Infect Dis Dept, Tanta, Egypt.
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- Abdo, Ehab F. (författare)
- Assiut Univ, Fac Med, Trop Med & Gastroenterol Dept, Assiut, Egypt.
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- Abella, Benjamin S. (författare)
- Univ Penn, Dept Emergency Med, Philadelphia, PA 19104 USA.
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- Akram, Javed (författare)
- Univ Hlth Sci, Dept Internal Med, Lahore, Punjab, Pakistan.
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- Amaravadi, Ravi K. (författare)
- Univ Penn, Abramson Canc Ctr, Philadelphia, PA 19104 USA.;Univ Penn, Dept Med, Philadelphia, PA 19104 USA.
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- Angus, Derek C. (författare)
- Univ Pittsburgh, Clin Res Invest & Syst Modeling Acute Illness CRI, Dept Crit Care Med, Pittsburgh, PA USA.;Univ Pittsburgh, UPMC Hlth Syst Off Healthcare Innovat, Med Ctr, Pittsburgh, PA USA.
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- Arabi, Yaseen M. (författare)
- King Saud Bin Abdulaziz Univ Hlth Sci, Intens Care Dept, Riyadh, Saudi Arabia.;King Abdullah Int Med Res Ctr, Riyadh, Saudi Arabia.
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- Azhar, Shehnoor (författare)
- Univ Hlth Sci, Dept Publ Hlth, Lahore, Punjab, Pakistan.
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- Baden, Lindsey R. (författare)
- Brigham & Womens Hosp, Div Infect Dis, 75 Francis St, Boston, MA 02115 USA.
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- Baker, Arthur W. (författare)
- Duke Univ, Med Ctr, Dept Med, Div Infect Dis & Int Hlth, Durham, NC 27710 USA.
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- Belkhir, Leila (författare)
- Catholic Univ Louvain, Infect Dis Dept, Clin Univ St Luc, Brussels, Belgium.
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- Benfield, Thomas (författare)
- Copenhagen Univ Hosp, Ctr Res & Disrupt Infect Dis, Dept Infect Dis, Hvidovre, Denmark.
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- Berrevoets, Marvin A. H. (författare)
- Elisabeth Tweesteden Hosp, Dept Internal Med, Tilburg, Netherlands.
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- Chen, Cheng-Pin (författare)
- Minist Hlth & Welf, Dept Infect Dis, Taoyuan Gen Hosp, Taoyuan, Taiwan.
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- Chen, Tsung-Chia (författare)
- Minist Hlth & Welf, Dept Internal Med, Taichung Hosp, Taichung, Taiwan.
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- Cheng, Shu-Hsing (författare)
- Minist Hlth & Welf, Dept Infect Dis, Taoyuan Gen Hosp, Taoyuan, Taiwan.
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- Cheng, Chien-Yu (författare)
- Minist Hlth & Welf, Dept Infect Dis, Taoyuan Gen Hosp, Taoyuan, Taiwan.
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- Chung, Wei-Sheng (författare)
- Minist Hlth & Welf, Dept Internal Med, Taichung Hosp, Taichung, Taiwan.
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- Cohen, Yehuda Z. (författare)
- Sanofi, Bridgewater, NJ USA.
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- Cowan, Lisa N. (författare)
- Sanofi, Bridgewater, NJ USA.
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- Dalgard, Olav (författare)
- Akershus Univ Hosp, Dept Infect Dis, Div Med, Lorenskog, Norway.;Univ Oslo, Fac Med, Inst Clin Med, Oslo, Norway.
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- de Almeida e Val, Fernando F. (författare)
- Fundacao Med Trop Dr Heitor Vieira Dourado, Manaus, Amazonas, Brazil.
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- de Lacerda, Marcus V. G. (författare)
- Fundacao Med Trop Dr Heitor Vieira Dourado, Manaus, Amazonas, Brazil.;FIOCRUZ AM, Inst Leonidas & Maria Deane ILMD, Manaus, Amazonas, Brazil.
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- de Melo, Gisely C. (författare)
- Fundacao Med Trop Dr Heitor Vieira Dourado, Manaus, Amazonas, Brazil.;Univ Estado Amazonas, Manaus, Amazonas, Brazil.
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- Derde, Lennie (författare)
- Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands.;Univ Med Ctr Utrecht, Intens Care Ctr, Utrecht, Netherlands.
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- Dubee, Vincent (författare)
- Angers Univ Hosp, Infect & Trop Dis Dept, Angers, France.
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- Elfakir, Anissa (författare)
- Ividata Life Sci, Levallois Perret, France.
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- Gordon, Anthony C. (författare)
- Imperial Coll London, Dept Surg & Canc Anaesthet Pain Med & Intens Care, London, England.;Imperial Coll Healthcare NHS Trust, London, England.
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- Hernandez-Cardenas, Carmen M. (författare)
- Inst Nacl Enfermedades Resp Ismael Cosio Villegas, Crit Care Dept, Ciudad De Mexico, Mexico.
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- Hills, Thomas (författare)
- Med Res Inst New Zealand, Wellington, New Zealand.;Auckland City Hosp, Auckland, New Zealand.
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- Hoepelman, Andy I. M. (författare)
- Univ Med Ctr Utrecht, Dept Infect Dis, Utrecht, Netherlands.
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- Huang, Yi-Wen (författare)
- Minist Hlth & Welf, Dept Internal Med, Chang Hua Hosp, Changhua, Taiwan.
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- Igau, Bruno (författare)
- Sanofi, Bridgewater, NJ USA.
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- Jin, Ronghua (författare)
- Capital Med Univ, Beijing Youan Hosp, Beijing, Peoples R China.
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- Jurado-Camacho, Felipe (författare)
- Inst Nacl Enfermedades Resp Ismael Cosio Villegas, Crit Care Dept, Ciudad De Mexico, Mexico.
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- Khan, Khalid S. (författare)
- Univ Granada, Hosp Real, Dept Prevent Med & Publ Hlth, Ave Hosp, Granada, Spain.
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- Kremsner, Peter G. (författare)
- Univ Tubingen, Inst Trop Med, Tubingen, Germany.;Ctr Rech Med Lambarene, Lambarene, Gabon.;German Ctr Infect Res, Partner Site Tubingen, Tubingen, Germany.
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- Kreuels, Benno (författare)
- Univ Med Ctr Hamburg Eppendorf, Dept Med, Div Trop Med, Hamburg, Germany.;Univ Med Ctr Hamburg Eppendorf, Div Infect Dis, Hamburg, Germany.;Bernhard Nocht Inst Trop Med, Dept Trop Med, Hamburg, Germany.
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- Kuo, Cheng-Yu (författare)
- Minist Hlth & Welf, Dept Internal Med, Pingtung Hosp, Pingtung, Taiwan.
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Le, Thuy (författare)
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- Lin, Yi-Chun (författare)
- Minist Hlth & Welf, Dept Infect Dis, Taoyuan Gen Hosp, Taoyuan, Taiwan.
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- Lin, Wu-Pu (författare)
- Minist Hlth & Welf, Dept Internal Med, Taipei Hosp, New Taipei, Taiwan.
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- Lin, Tse-Hung (författare)
- Minist Hlth & Welf, Dept Internal Med, Chang Hua Hosp, Changhua, Taiwan.
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- Lyngbakken, Magnus Nakrem (författare)
- Univ Oslo, Fac Med, Inst Clin Med, Oslo, Norway.;Akershus Univ Hosp, Div Med, Lorenskog, Norway.
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- McArthur, Colin (författare)
- Med Res Inst New Zealand, Wellington, New Zealand.;Auckland City Hosp, Auckland, New Zealand.;Monash Univ, Australian & New Zealand Intens Care Res Ctr, Sch Epidemiol & Prevent Med, Melbourne, Vic, Australia.
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- McVerry, Bryan J. (författare)
- Univ Pittsburgh, Dept Med, Pittsburgh, PA USA.
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- Meza-Meneses, Patricia (författare)
- Hosp Reg Alta Especialidad Ixtapaluca, Ixtapaluca, Mexico.
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- Monteiro, Wuelton M. (författare)
- Fundacao Med Trop Dr Heitor Vieira Dourado, Manaus, Amazonas, Brazil.;Univ Estado Amazonas, Manaus, Amazonas, Brazil.
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- Morpeth, Susan C. (författare)
- Middlemore Hosp, Auckland, New Zealand.
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- Mourad, Ahmad (författare)
- Duke Univ, Dept Med, Med Ctr, Durham, NC 27710 USA.
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- Mulligan, Mark J. (författare)
- NYU Grossman Sch Med, Dept Microbiol, New York, NY USA.;NYU Grossman Sch Med, Dept Internal Med, Div Infect Dis & Immunol, New York, NY USA.
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- Murthy, Srinivas (författare)
- Univ British Columbia, Sch Med, Vancouver, BC, Canada.
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- Naggie, Susanna (författare)
- Duke Univ, Med Ctr, Dept Med, Div Infect Dis & Int Hlth, Durham, NC 27710 USA.
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- Narayanasamy, Shanti (författare)
- Duke Univ, Med Ctr, Dept Med, Div Infect Dis & Int Hlth, Durham, NC 27710 USA.
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- Nichol, Alistair (författare)
- Monash Univ, Australian & New Zealand Intens Care Res Ctr, Sch Epidemiol & Prevent Med, Melbourne, Vic, Australia.;Alfred Hlth, Dept Intens Care, Melbourne, Vic, Australia.;St Vincents Univ Hosp, Dept Anesthesia & Intens Care, Dublin, Ireland.;Univ Coll Dublin, Sch Med & Med Sci, Dublin, Ireland.
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- Novack, Lewis A. (författare)
- Harvard Med Sch, Brigham & Womens Hosp, Div Infect Dis, Boston, MA 02115 USA.
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- O'Brien, Sean M. (författare)
- Duke Univ, Dept Biostat & Bioinformat, Med Ctr, Durham, NC USA.;Duke Clin Res Inst, Durham, NC USA.
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- Okeke, Nwora Lance (författare)
- Duke Univ, Med Ctr, Dept Med, Div Infect Dis & Int Hlth, Durham, NC 27710 USA.
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- Perez, Lena (författare)
- Excelya, Montpellier, France.
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- Perez-Padilla, Rogelio (författare)
- Inst Nacl Enfermedades Resp Ismael Casio Villegas, Dept Smoking & COPD, Ciudad De Mexico, Mexico.
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- Perrin, Laurent (författare)
- Sanofi, Montpellier, France.
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- Remigio-Luna, Arantxa (författare)
- Inst Nacl Enfermedades Resp Ismael Casio Villegas, Dept Smoking & COPD, Ciudad De Mexico, Mexico.
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- Rivera-Martinez, Norma E. (författare)
- Hosp Reg Alta Especialidad Oaxaca, Oaxaca, Oaxaca, Mexico.
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- Rockhold, Frank W. (författare)
- Duke Univ, Dept Biostat & Bioinformat, Med Ctr, Durham, NC USA.;Duke Clin Res Inst, Durham, NC USA.
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- Rodriguez-Llamazares, Sebastian (författare)
- Inst Nacl Enfermedades Resp Ismael Casio Villegas, Dept Smoking & COPD, Ciudad De Mexico, Mexico.
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- Rolfe, Robert (författare)
- Duke Univ, Med Ctr, Dept Med, Div Infect Dis & Int Hlth, Durham, NC 27710 USA.
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- Rosa, Rossana (författare)
- UnityPoint Hlth, Des Moines, IA USA.
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- Rosjo, Helge (författare)
- Univ Oslo, Fac Med, Inst Clin Med, Oslo, Norway.;Akershus Univ Hosp, Div Res & Innovat, Lorenskog, Norway.
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- Sampaio, Vanderson S. (författare)
- Fundacao Med Trop Dr Heitor Vieira Dourado, Manaus, Amazonas, Brazil.;Fundacao Vigilancia Saude Amazonas, Manaus, Amazonas, Brazil.
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- Seto, Todd B. (författare)
- Univ Hawaii, John A Burns Sch Med, Honolulu, HI 96822 USA.;Queens Med Ctr, Honolulu, HI USA.
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- Shahzad, Muhammad (författare)
- Univ Hlth Sci, Dept Pharmacol, Lahore, Punjab, Pakistan.
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- Soliman, Shaimaa (författare)
- Menoufia Univ, Publ Hlth & Community Med, Menoufia, Egypt.
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- Stout, Jason E. (författare)
- Duke Univ, Med Ctr, Dept Med, Div Infect Dis & Int Hlth, Durham, NC 27710 USA.
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- Thirion-Romero, Ireri (författare)
- Inst Nacl Enfermedades Resp Ismael Casio Villegas, Dept Smoking & COPD, Ciudad De Mexico, Mexico.
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- Troxel, Andrea B. (författare)
- NYU Grossman Sch Med, Dept Populat Hlth, Div Biostat, New York, NY USA.
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- Tseng, Ting-Yu (författare)
- Minist Hlth & Welf, Dept Internal Med, Taichung Hosp, Taichung, Taiwan.
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- Turner, Nicholas A. (författare)
- Duke Univ, Med Ctr, Dept Med, Div Infect Dis & Int Hlth, Durham, NC 27710 USA.
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- Ulrich, Robert J. (författare)
- NYU Grossman Sch Med, Dept Med, Div Infect Dis & Immunol, New York, NY USA.
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- Walsh, Stephen R. (författare)
- Brigham & Womens Hosp, Div Infect Dis, 75 Francis St, Boston, MA 02115 USA.
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- Webb, Steve A. (författare)
- Monash Univ, Australian & New Zealand Intens Care Res Ctr, Sch Epidemiol & Prevent Med, Melbourne, Vic, Australia.;St John God Hosp, Subiaco, WA, Australia.
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- Weehuizen, Jesper M. (författare)
- Univ Med Ctr Utrecht, Dept Infect Dis, Utrecht, Netherlands.
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- Velinova, Maria (författare)
- PRA Hlth Sci, Groningen, Netherlands.
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- Wong, Hon-Lai (författare)
- Minist Hlth & Welf, Dept Internal Med, Keelung Hosp, Keelung, Taiwan.
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- Wrenn, Rebekah (författare)
- Duke Univ, Med Ctr, Dept Med, Div Infect Dis & Int Hlth, Durham, NC 27710 USA.
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- Zampieri, Fernando G. (författare)
- HCor Hosp Coracao, Res Inst, Sao Paulo, Brazil.;BRICNet Brazilian Res Intens Care Network, Res Inst, Sao Paulo, Brazil.;IDor Res Inst, Sao Paulo, Brazil.
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- Zhong, Wu (författare)
- Beijing Inst Pharmacol & Toxicol, Natl Engn Res Ctr Emergency Drug, Beijing, Peoples R China.
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- Moher, David (författare)
- Ottawa Hosp Res Inst, Ctr Journalol, Clin Epidemiol Program, Ottawa, ON, Canada.
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- Goodman, Steven N. (författare)
- Stanford Univ, Meta Res Innovat Ctr Stanford METRICS, Stanford, CA 94305 USA.;Stanford Univ, Sch Med, Stanford, CA 94305 USA.;Stanford Univ, Dept Epidemiol & Populat Hlth, Sch Med, Stanford, CA 94305 USA.
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- Ioannidis, John P. A. (författare)
- Stanford Univ, Meta Res Innovat Ctr Stanford METRICS, Stanford, CA 94305 USA.;Stanford Univ, Sch Med, Stanford, CA 94305 USA.;Stanford Univ, Dept Epidemiol & Populat Hlth, Sch Med, Stanford, CA 94305 USA.;Stanford Univ, Dept Med, Stanford Prevent Res Ctr, Stanford, CA 94305 USA.;Berlin Inst Hlth, Meta Res Innovat Ctr Berlin METRIC B, Berlin, Germany.
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- Hemkens, Lars G. (författare)
- Stanford Univ, Meta Res Innovat Ctr Stanford METRICS, Stanford, CA 94305 USA.;Univ Basel, Univ Hosp Basel, Dept Clin Res, Basel, Switzerland.;Berlin Inst Hlth, Meta Res Innovat Ctr Berlin METRIC B, Berlin, Germany.
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(creator_code:org_t)
- 2021-04-15
- 2021
- Engelska.
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Ingår i: Nature Communications. - : Springer Nature. - 2041-1723. ; 12:1
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Substantial COVID-19 research investment has been allocated to randomized clinical trials (RCTs) on hydroxychloroquine/chloroquine, which currently face recruitment challenges or early discontinuation. We aim to estimate the effects of hydroxychloroquine and chloroquine on survival in COVID-19 from all currently available RCT evidence, published and unpublished. We present a rapid meta-analysis of ongoing, completed, or discontinued RCTs on hydroxychloroquine or chloroquine treatment for any COVID-19 patients (protocol: https://osf.io/QESV4/). We systematically identified unpublished RCTs (ClinicalTrials.gov, WHO International Clinical Trials Registry Platform, Cochrane COVID-registry up to June 11, 2020), and published RCTs (PubMed, medRxiv and bioRxiv up to October 16, 2020). All-cause mortality has been extracted (publications/preprints) or requested from investigators and combined in random-effects meta-analyses, calculating odds ratios (ORs) with 95% confidence intervals (CIs), separately for hydroxychloroquine and chloroquine. Prespecified subgroup analyses include patient setting, diagnostic confirmation, control type, and publication status. Sixty-three trials were potentially eligible. We included 14 unpublished trials (1308 patients) and 14 publications/preprints (9011 patients). Results for hydroxychloroquine are dominated by RECOVERY and WHO SOLIDARITY, two highly pragmatic trials, which employed relatively high doses and included 4716 and 1853 patients, respectively (67% of the total sample size). The combined OR on all-cause mortality for hydroxychloroquine is 1.11 (95% CI: 1.02, 1.20; I-2=0%; 26 trials; 10,012 patients) and for chloroquine 1.77 (95%CI: 0.15, 21.13, I-2=0%; 4 trials; 307 patients). We identified no subgroup effects. We found that treatment with hydroxychloroquine is associated with increased mortality in COVID-19 patients, and there is no benefit of chloroquine. Findings have unclear generalizability to outpatients, children, pregnant women, and people with comorbidities. Hydroxychloroquine and chloroquine have been investigated as a potential treatment for Covid-19 in several clinical trials. Here the authors report a meta-analysis of published and unpublished trials, and show that treatment with hydroxychloroquine for patients with Covid-19 was associated with increased mortality, and there was no benefit from chloroquine.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
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Axfors, Cathrine
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Schmitt, Andreas ...
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Janiaud, Perrine
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van't Hooft, Jan ...
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Abd-Elsalam, She ...
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Abdo, Ehab F.
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visa fler...
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Abella, Benjamin ...
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Akram, Javed
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Amaravadi, Ravi ...
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Angus, Derek C.
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Arabi, Yaseen M.
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Azhar, Shehnoor
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Baden, Lindsey R ...
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Baker, Arthur W.
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Belkhir, Leila
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Benfield, Thomas
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Berrevoets, Marv ...
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Chen, Cheng-Pin
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Chen, Tsung-Chia
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Cheng, Shu-Hsing
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Cheng, Chien-Yu
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Chung, Wei-Sheng
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Cohen, Yehuda Z.
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Cowan, Lisa N.
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Dalgard, Olav
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de Almeida e Val ...
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de Lacerda, Marc ...
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de Melo, Gisely ...
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Derde, Lennie
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Dubee, Vincent
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Elfakir, Anissa
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Gordon, Anthony ...
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Hernandez-Carden ...
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Hills, Thomas
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Hoepelman, Andy ...
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Huang, Yi-Wen
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Igau, Bruno
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Jin, Ronghua
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Jurado-Camacho, ...
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Khan, Khalid S.
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Kremsner, Peter ...
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Kreuels, Benno
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Kuo, Cheng-Yu
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Le, Thuy
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Lin, Yi-Chun
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Lin, Wu-Pu
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Lin, Tse-Hung
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Lyngbakken, Magn ...
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McArthur, Colin
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McVerry, Bryan J ...
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Meza-Meneses, Pa ...
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Monteiro, Wuelto ...
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Morpeth, Susan C ...
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Mourad, Ahmad
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Mulligan, Mark J ...
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Murthy, Srinivas
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Naggie, Susanna
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Narayanasamy, Sh ...
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Nichol, Alistair
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Novack, Lewis A.
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O'Brien, Sean M.
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Okeke, Nwora Lan ...
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Perez, Lena
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Perez-Padilla, R ...
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Perrin, Laurent
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Remigio-Luna, Ar ...
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Rivera-Martinez, ...
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Rockhold, Frank ...
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Rodriguez-Llamaz ...
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Rolfe, Robert
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Rosa, Rossana
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Rosjo, Helge
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Sampaio, Vanders ...
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Seto, Todd B.
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Shahzad, Muhamma ...
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Soliman, Shaimaa
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Stout, Jason E.
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Thirion-Romero, ...
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Troxel, Andrea B ...
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Tseng, Ting-Yu
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Turner, Nicholas ...
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Ulrich, Robert J ...
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Walsh, Stephen R ...
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Webb, Steve A.
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Weehuizen, Jespe ...
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Velinova, Maria
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Wong, Hon-Lai
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Wrenn, Rebekah
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Zampieri, Fernan ...
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Zhong, Wu
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Moher, David
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Goodman, Steven ...
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Ioannidis, John ...
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Hemkens, Lars G.
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