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Sökning: WFRF:(Sayols Baixeras Sergi) > (2021) > DNA methylation bio...

  • Fernandez-Sanles, AlbaIMIM Hosp del Mar Med Res Inst, Cardiovasc Epidemiol & Genet Res Grp, REGICOR Study Grp, Dr Aiguader 88, Barcelona 08003, Catalonia, Spain.;Pompeu Fabra Univ UPF, Barcelona, Catalonia, Spain.;Univ Bristol, Med Res Council MRC, Integrat Epidemiol Unit, Bristol, Avon, England. (författare)

DNA methylation biomarkers of myocardial infarction and cardiovascular disease

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • 2021-04-21
  • BioMed Central (BMC),2021
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-443065
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-443065URI
  • https://doi.org/10.1186/s13148-021-01078-6DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background: The epigenetic landscape underlying cardiovascular disease (CVD) is not completely understood and the clinical value of the identified biomarkers is still limited. We aimed to identify differentially methylated loci associated with acute myocardial infarction (AMI) and assess their validity as predictive and causal biomarkers.Results: We designed a case-control, two-stage, epigenome-wide association study on AMI (n(discovery) = 391, n(validation) = 204). DNA methylation was assessed using the Infinium MethylationEPIC BeadChip. We performed a fixed-effects meta-analysis of the two samples. 34 CpGs were associated with AMI. Only 12 of them were available in two independent cohort studies (n similar to 1800 and n similar to 2500) with incident coronary and cardiovascular disease (CHD and CVD, respectively). The Infinium HumanMethylation450 BeadChip was used in those two studies. Four of the 12 CpGs were validated in association with incident CHD: AHRR-mapping cg05575921, PTCD2-mapping cg25769469, intergenic cg21566642 and MPO-mapping cg04988978. We then assessed whether methylation risk scores based on those CpGs improved the predictive capacity of the Framingham risk function, but they did not. Finally, we aimed to study the causality of those associations using a Mendelian randomization approach but only one of the CpGs had a genetic influence and therefore the results were not conclusive.Conclusions: We have identified 34 CpGs related to AMI. These loci highlight the relevance of smoking, lipid metabolism, and inflammation in the biological mechanisms related to AMI. Four were additionally associated with incident CHD and CVD but did not provide additional predictive information.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Sayols-Baixeras, SergiUppsala universitet,Molekylär epidemiologi,IMIM Hosp del Mar Med Res Inst, Cardiovasc Epidemiol & Genet Res Grp, REGICOR Study Grp, Dr Aiguader 88, Barcelona 08003, Catalonia, Spain.;CIBER Cardiovasc Dis CIBERCV, Madrid, Spain.(Swepub:uu)sersa467 (författare)
  • Subirana, IsaacIMIM Hosp del Mar Med Res Inst, Cardiovasc Epidemiol & Genet Res Grp, REGICOR Study Grp, Dr Aiguader 88, Barcelona 08003, Catalonia, Spain.;CIBER Epidemiol & Publ Hlth CIBERESP, Madrid, Spain. (författare)
  • Senti, MarianoPompeu Fabra Univ UPF, Barcelona, Catalonia, Spain. (författare)
  • Perez-Fernandez, S.IMIM Hosp del Mar Med Res Inst, Cardiovasc Epidemiol & Genet Res Grp, REGICOR Study Grp, Dr Aiguader 88, Barcelona 08003, Catalonia, Spain.;CIBER Cardiovasc Dis CIBERCV, Madrid, Spain. (författare)
  • de Castro Moura, ManuelJosep Carreras Leukaemia Res Inst IJC, Badalona, Catalonia, Spain. (författare)
  • Esteller, ManelJosep Carreras Leukaemia Res Inst IJC, Badalona, Catalonia, Spain.;CIBER Oncol CIBERONC, Madrid, Spain.;Catalan Inst Res & Adv Studies ICREA, Barcelona, Catalonia, Spain.;Univ Barcelona UB, Sch Med & Hlth Sci, Physiol Sci Dept, Barcelona, Catalonia, Spain. (författare)
  • Marrugat, JaumeIMIM Hosp del Mar Med Res Inst, Cardiovasc Epidemiol & Genet Res Grp, REGICOR Study Grp, Dr Aiguader 88, Barcelona 08003, Catalonia, Spain.;CIBER Cardiovasc Dis CIBERCV, Madrid, Spain. (författare)
  • Elosua, RobertoIMIM Hosp del Mar Med Res Inst, Cardiovasc Epidemiol & Genet Res Grp, REGICOR Study Grp, Dr Aiguader 88, Barcelona 08003, Catalonia, Spain.;CIBER Cardiovasc Dis CIBERCV, Madrid, Spain.;Univ Vic, Cent Univ Catalonia UVic UCC, Fac Med, Med Dept, Vic, Catalonia, Spain. (författare)
  • IMIM Hosp del Mar Med Res Inst, Cardiovasc Epidemiol & Genet Res Grp, REGICOR Study Grp, Dr Aiguader 88, Barcelona 08003, Catalonia, Spain.;Pompeu Fabra Univ UPF, Barcelona, Catalonia, Spain.;Univ Bristol, Med Res Council MRC, Integrat Epidemiol Unit, Bristol, Avon, England.Molekylär epidemiologi (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Clinical Epigenetics: BioMed Central (BMC)131868-70831868-7075

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