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  • Liu, JianpingKarolinska Institutet,Karolinska Inst, Dept Med Huddinge, Huddinge, Sweden. (author)

A human cell type similar to murine central nervous system perivascular fibroblasts

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • Elsevier,2021
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-443075
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-443075URI
  • https://doi.org/10.1016/j.yexcr.2021.112576DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:146444814URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • The brain vasculature has several specific features, one of them being the blood-brain barrier (BBB), which supports and protects the brain by allowing for the passage of oxygen and nutrients, while at the same time preventing passage of pathogens and toxins. The BBB also prevents efficient delivery of drugs to the brain, e.g. for treatment of brain tumors. In the murine brain, perivascular fibroblasts were recently identified as a novel potential constituent of the BBB. Here we present the existence of human cells that could be the equivalent to the murine brain perivascular fibroblasts. Using RNA sequencing, we show a similar transcriptomic profile of cultured human brain cells and murine perivascular fibroblasts. These data open up a window for new hypotheses on cell types involved in human CNS diseases.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • He, LiqunUppsala universitet,Vaskulärbiologi,Tianjin Med Univ, Tianjin Neurol Inst, Dept Neurosurg,Gen Hosp,Minist Educ & Tianjin Cit, Key Lab Postneuroinjury Neuro Repair & Regenerat, Tianjin 300052, Peoples R China.(Swepub:uu)liqhe592 (author)
  • Muhl, LarsKarolinska Institutet,Karolinska Inst, Dept Med Huddinge, Huddinge, Sweden. (author)
  • Mocci, GiuseppeKarolinska Inst, Dept Med Huddinge, Huddinge, Sweden. (author)
  • Gustavsson, SonjaKarolinska Inst, Dept Med, Single Cell Core Facil, Huddinge, Sweden. (author)
  • Buyandelger, ByambajavKarolinska Inst, Dept Med, Single Cell Core Facil, Huddinge, Sweden. (author)
  • Vanlandewijck, MichaelKarolinska Inst, Dept Med Huddinge, Huddinge, Sweden. (author)
  • Betsholtz, ChristerUppsala universitet,Vaskulärbiologi(Swepub:uu)chbet517 (author)
  • Westermark, BengtUppsala universitet,Neuroonkologi(Swepub:uu)bengtwm (author)
  • Andrae, JohannaUppsala universitet,Vaskulärbiologi(Swepub:uu)johaandr (author)
  • Karolinska InstitutetKarolinska Inst, Dept Med Huddinge, Huddinge, Sweden. (creator_code:org_t)

Related titles

  • In:Experimental Cell Research: Elsevier402:20014-48271090-2422

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