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A global point prev...
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Prusakov, PavelNationwide Childrens Hosp, Dept Pharm, Columbus, OH USA.
(author)
A global point prevalence survey of antimicrobial use in neonatal intensive care units : The no-more-antibiotics and resistance (NO-MAS-R) study
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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Elsevier,2021
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-443481
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-443481URI
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https://doi.org/10.1016/j.eclinm.2021.100727DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Background: Global assessment of antimicrobial agents prescribed to infants in the neonatal intensive care unit (NICU) may inform antimicrobial stewardship efforts.Methods: We conducted a one-day global point prevalence study of all antimicrobials provided to NICU infants. Demographic, clinical, and microbiologic data were obtained including NICU level, census, birth weight, gestational/chronologic age, diagnoses, antimicrobial therapy (reason for use; length of therapy), antimicrobial stewardship program (ASP), and 30-day in-hospital mortality.Findings: On July 1, 2019, 26% of infants (580/2,265; range, 0-100%; median gestational age, 33 weeks; median birth weight, 1800 g) in 84 NICUs (51, high-income; 33, low-to-middle income) from 29 countries (14, high-income; 15, low-to-middle income) in five continents received >= 1 antimicrobial agent (92%, antibacterial; 19%, antifungal; 4%, antiviral). The most common reasons for antibiotic therapy were "rule-out" sepsis (32%) and "culture-negative" sepsis (16%) with ampicillin (40%), gentamicin (35%), amikacin (19%), vancomycin (15%), and meropenem (9%) used most frequently. For definitive treatment of presumed/confirmed infection, vancomycin (26%), amikacin (20%), and meropenem (16%) were the most prescribed agents. Length of therapy for culture-positive and "culture-negative" infections was 12 days (median; IQR, 8-14) and 7 days (median; IQR, 5-10), respectively. Mortality was 6% (42%, infection-related). An NICU ASP was associated with lower rate of antibiotic utilization (p = 0.02).Interpretation: Global NICU antibiotic use was frequent and prolonged regardless of culture results. NICU-specific ASPs were associated with lower antibiotic utilization rates, suggesting the need for their implementation worldwide.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Goff, Debra A.Ohio State Univ, Coll Pharm, Wexner Med Ctr, Dept Pharm, 500 W 12Th Ave, Columbus, OH 43210 USA.
(author)
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Wozniak, Phillip S.Ohio State Univ, Coll Med, Columbus, OH 43210 USA.
(author)
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Cassim, AzraaChris Hani Baragwanath Hosp, Johannesburg, South Africa.
(author)
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Scipion, Catherine E. A.Hlth Equ Int, Fond Des Blancs, Haiti.
(author)
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Urzua, SoledadPontificia Univ Catolica, Dept Neonatol, Santiago, Chile.
(author)
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Ronchi, AndreaFdn IRCCS CaGranda Osped Maggiore Policlin, Div Neonatol & NICU, Milan, Italy.
(author)
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Zeng, LingkongHuazhong Univ Sci & Technol, Dept Neonatol, Wuhan Childrens Hosp, Wuhan Maternal & Child Healthcare Hosp,Tongji Med, Wuhan, Peoples R China.
(author)
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Ladipo-Ajayi, OluwaseunLagos Univ Teaching Hosp, Dept Pediat Surg, Lagos, Nigeria.
(author)
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Aviles-Otero, NoeliaUniv Virginia, Sch Med, Charlottesville, VA 22908 USA.
(author)
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Udeigwe-Okeke, Chisom R.Natl Hosp, Div Paediat Surg, Abuja, Nigeria.
(author)
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Melamed, RimmaBen Gurion Univ Negev, Soroka Univ Med Ctr, Pediat Infect Dis Unit, Beer Sheva, Israel.;Ben Gurion Univ Negev, Soroka Univ Med Ctr, Fac Hlth Sci, Beer Sheva, Israel.
(author)
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Silveira, Rita C.Univ Fed Rio Grande Do Sul, Dept Pediat, Newborn Sect, Hosp Clin Porto Alegre, Porto Alegre, RS, Brazil.
(author)
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Auriti, CinziaBambino Gesu Pediat Hosp, Dept Neonatol, Rome, Italy.
(author)
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Beltran-Arroyave, ClaudiaClin Prado, Medellin, Colombia.;Clin El Rosario, Medellin, Colombia.
(author)
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Zamora-Flores, ElenaGregorio Maranon Univ Hosp, Div Neonatol, Hosp Materno Infantil, Madrid, Spain.
(author)
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Sanchez-Codez, MariaPuerta Mar Univ Hosp, Div Pediat Infect Dis, Cadiz, Spain.
(author)
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Donkor, Eric S.Univ Ghana, Dept Med Microbiol, Med Sch, Accra, Ghana.
(author)
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Kekomaki, SatuHelsinki Univ Hosp, Childrens Hosp, Div Pediat Infect Dis, Helsinki, Finland.
(author)
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Mainini, NicolettaTreviso Hosp, Div Neonatol, Treviso, Italy.
(author)
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Trochez, Rosalba VivasCES Univ, Procaren NICU, Clin Soma, Medellin, Colombia.
(author)
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Casey, JamalynSt Vincent Womens Hosp, Dept Pharm, Indianapolis, IN USA.
(author)
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Graus, Juan M.Hosp Nacl Cayetano Heredia, Dept Neonatol, Lima, Peru.
(author)
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Muller, MalloryArnold Palmer Hosp Children, Dept Pharm, Orlando, FL USA.
(author)
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Singh, SaraUniv Guyana, Sch Med, Georgetown, Guyana.
(author)
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Loeffen, YvetteWilhelmina Childrens Hosp, Div Pediat Immunol & Infect Dis, Utrecht, Netherlands.
(author)
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Tamayo Perez, Maria EulaliaUniv Antioquia, Hosp San Vicente Fdn, Head Neonatal Intens Care, Coordinator Neonatol Fellow Program, Medellin, Colombia.
(author)
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Ferreyra, Gloria IsabelInst Maternidad Ntra Sra Las Mercedes, Dept Neonatol, San Miguel De Tucuman, Tucuman, Argentina.
(author)
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Lima-Rogel, VictoriaHosp Gen Dr Ignacio Morones Prieto, Div Neonatol, San Luis Potosi, San Luis Potosi, Mexico.
(author)
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Perrone, BarbaraG Salesi Childrens Hosp, Div Neonatol, Ancona, Italy.;NICU, Ancona, Italy.
(author)
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Izquierdo, GianninaHosp Barros Luco, Div Neonatol & Pediat Infect Dis, Santiago, Chile.
(author)
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Cernada, MariaLa Fe Univ, Div Neonatol, Valencia, Spain.;La Fe Univ, Neonatal Res Grp, Valencia, Spain.;Polytech Hosp, Valencia, Spain.
(author)
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Stoffella, SylviaUCSF, Dept Pharm, Benioff Childrens Hosp, San Francisco, CA USA.
(author)
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Ekenze, Sebastian OkwuchukwuUniv Nigeria Teaching Hosp, Sub Dept Pediat Surg, Enugu, Nigeria.
(author)
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de Alba-Romero, ConcepcionHosp 12 Octubre, Div Neonatol, Madrid, Spain.
(author)
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Tzialla, ChryssoulaFdn IRCCS Policlin San Matteo, Pavia, Italy.
(author)
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Pham, Jennifer T.Univ Illinois, Coll Pharm, Hosp & Hlth Sci Syst, Chicago, IL USA.
(author)
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Hosoi, KenichiroKyorin Univ, Dept Pediat, Sch Med, Tokyo, Japan.
(author)
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Consuegra, Magdalena Cecilia CaleroHosp Gen San Francisco, Div Neonatol, Quito, Ecuador.
(author)
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Betta, PasquaAOU Policlin G Rodol, Div Neonatol & NICU, Catania, Italy.
(author)
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Hoyos, O. AlvaroUniv Pontificia Bolivariana, Clin Univ Bolivariana, Medellin, Colombia.
(author)
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Roilides, EmmanuelAristotle Univ Thessaloniki, Fac Med, Dept Pediat 3, Infect Dis Unit,Sch Hlth Sci, Thessaloniki, Greece.
(author)
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Naranjo-Zuniga, GabrielaHosp Nacl Ninos Dr Carlos Saenz Herrera, Div Pediat Infect Dis, San Jose, Costa Rica.
(author)
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Oshiro, MakotoNagoya Red Cross Daiichi Hosp, Dept Pediat, Nagoya, Aichi, Japan.
(author)
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Garay, VictorAlberto Sabogal Hosp, Div Neonatol, Lima, Peru.
(author)
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Mondi, VitoPoliclin Casilino, Rome, Italy.
(author)
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Mazzeo, DanilaAOU Policlin Messina, Div Patol & Intens Neonatal Care, Messina, Italy.
(author)
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Stahl, James A.Norton Childrens Hosp, Dept Pharm, Louisville, KY USA.
(author)
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Cantey, Joseph B.Univ Hosp UT Hlth San Antonio, Dept Pediat, Div Neonatol, San Antonio, TX USA.
(author)
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Monsalve, Juan Gonzalo MesaHosp Gen Medellin, Pediat Infect Dis, Medellin, Colombia.
(author)
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Normann, ErikUppsala universitet,Perinatal, neonatal och barnkardiologisk forskning(Swepub:uu)ernor031
(author)
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Landgrave, Lindsay C.Parkview Reg Med Ctr, Dept Pharm, Ft Wayne, IN USA.
(author)
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Mazouri, AliIran Univ Med Sci, Tehran, Iran.
(author)
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Avila, Claudia AlarconNueva Granada Mil Univ, Cent Mil Hosp, Dept Perinatol & Neonatol, Bogota, Colombia.
(author)
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Piersigilli, FiammettaClin Univ St Luc, Dept Neonatol, Brussels, Belgium.
(author)
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Trujillo, MonicaClin Univ Bolivariana, Hosp Pablo Tobon Uribe, Program Coordinator Pediat Infect Dis, Medellin, Colombia.
(author)
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Kolman, SonyaNelson Mandela Children Hosp, Dept Pharm, Johannesburg, South Africa.
(author)
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Delgado, VeronicaHosp Los Valles, Head Neonatal Intens Care, Quito, Ecuador.
(author)
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Guzman, VeronicaPontificia Univ Catolica Ecuador, Hosp Metropolitano Quito, Quito, Ecuador.
(author)
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Abdellatif, MohamedSultan Qaboos Univ Hosp, Child Hlth Dept, Muscat, Oman.
(author)
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Monterrosa, LuisSt Johns Hosp, Div Neonatol, Dept Pediat, St John, NB, Canada.
(author)
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Tina, Lucia GabriellaARNAS Garibaldi, NICU Dept, Catania, Italy.
(author)
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Yunis, KhalidAmer Univ Beirut, Div Neonatol, Med Ctr, Beirut, Lebanon.
(author)
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Belzu Rodriguez, Marco AntonioMaternal & Children Hosp Tigre Dr Florencio Escar, Div Neonatol, Tigre, Argentina.
(author)
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Le Saux, NicoleChildrens Hosp Eastern Ontario, Dept Pediat, Div Infect Dis, Ottawa, ON, Canada.
(author)
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Leonardi, ValentinaCareggi Univ Hosp, Div Neonatol & NICU, Florence, Italy.
(author)
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Porta, AlessandroG Fornaroli Hosp, Magenta, Milan, Italy.
(author)
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Latorre, GiuseppeOsped Miulli, Acquaviva, Italy.
(author)
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Nakanishi, HidehikoKitasato Univ, Res & Dev Ctr New Med Frontiers, Dept Adv Med, Div Neonatal Intens Care Med,Sch Med, Sagamihara, Kanagawa, Japan.
(author)
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Meir, MichalRuth Rappaport Childrens Hosp, Div Pediat Infect Dis, Rambam Hlth Care Campus, Haifa, Israel.
(author)
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Manzoni, PaoloInfermi Hosp, Div Pediat & Neonatol, Biella, Italy.
(author)
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Norero, XimenaHosp Nino, Panama City, Panama.
(author)
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Hoyos, AngelaClin La Colina, Div Neonatol, Clin Country, Bogota, Colombia.
(author)
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Arias, DianaHosp San Jose, Bogota, Colombia.
(author)
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Sanchez, Ruben GarciaHosp Univ Salamanca, Salamanca, Spain.
(author)
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Medoro, Alexandra K.Ohio State Univ, Coll Med, Columbus, OH 43210 USA.;Nationwide Childrens Hosp, Abigail Wexner Res Inst, Ctr Perinatal Res, Dept Pediat,Div Neonatol & Pediat Infect Dis, Columbus, OH USA.
(author)
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Sanchez, Pablo J.Ohio State Univ, Coll Med, Columbus, OH 43210 USA.;Nationwide Childrens Hosp, Abigail Wexner Res Inst, Ctr Perinatal Res, Dept Pediat,Div Neonatol & Pediat Infect Dis, Columbus, OH USA.
(author)
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Nationwide Childrens Hosp, Dept Pharm, Columbus, OH USA.Ohio State Univ, Coll Pharm, Wexner Med Ctr, Dept Pharm, 500 W 12Th Ave, Columbus, OH 43210 USA.
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Prusakov, Pavel
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Cassim, Azraa
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