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The avian W chromos...
The avian W chromosome is a refugium for endogenous retroviruses with likely effects on female-biased mutational load and genetic incompatibilities
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- Peona, Valentina, 1990- (författare)
- Uppsala universitet,Systematisk biologi,Alexander Suh,Department of Organismal Biology—Systematic Biology, Uppsala University, Uppsala, Sweden
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- Palacios-Gimenez, Octavio M. (författare)
- Uppsala universitet,Systematisk biologi,Department of Organismal Biology—Systematic Biology, Uppsala University, Uppsala, Sweden
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- Blommaert, Julie (författare)
- Uppsala universitet,Systematisk biologi,Department of Organismal Biology—Systematic Biology, Uppsala University, Uppsala, Sweden
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- Liu, Jing (författare)
- MOE Laboratory of Biosystems Homeostasis and Protection, Life Sciences Institute, Zhejiang University, Hangzhou, People's Republic of China;Department of Neuroscience and Development, University of Vienna, Vienna, Austria
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- Haryoko, Tri (författare)
- Museum Zoologicum Bogoriense, Research Centre for Biology, Indonesian Institute of Sciences (LIPI), Cibinong, Indonesia
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- Jønsson, Knud A. (författare)
- Natural History Museum of Denmark, University of Copenhagen, Copenhagen, Denmark
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- Irestedt, Martin (författare)
- Naturhistoriska riksmuseet,Enheten för bioinformatik och genetik,Department of Bioinformatics and Genetics, Swedish Museum of Natural History, Stockholm, Sweden
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- Zhou, Qi (författare)
- MOE Laboratory of Biosystems Homeostasis and Protection, Life Sciences Institute, Zhejiang University, Hangzhou, People's Republic of China;Department of Neuroscience and Development, University of Vienna, Vienna, Austria;Center for Reproductive Medicine, The 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310052, People's Republic of China
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- Jern, Patric (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab,Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
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- Suh, Alexander (författare)
- Uppsala universitet,Systematisk biologi,Department of Organismal Biology—Systematic Biology, Uppsala University, Uppsala, Sweden;School of Biological Sciences—Organisms and the Environment, University of East Anglia, Norwich, UK
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(creator_code:org_t)
- 2021-07-26
- 2021
- Engelska.
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Ingår i: Philosophical Transactions of the Royal Society of London. Biological Sciences. - : Royal Society. - 0962-8436 .- 1471-2970. ; 376:1833
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Abstract
Ämnesord
Stäng
- It is a broadly observed pattern that the non-recombining regions of sex- limited chromosomes (Y and W) accumulate more repeats than the rest of the genome, even in species like birds with a low genome-wide repeat content. Here, we show that in birds with highly heteromorphic sex chromosomes, the W chromosome has a transposable element (TE) density of greater than 55% compared to the genome-wide density of less than 10%, and contains over half of all full-length (thus potentially active) endogenous retroviruses (ERVs) of the entire genome. Using RNA-seq and protein mass spectrometry data, we were able to detect signatures of female-specific ERV expression. We hypothesize that the avian W chromosome acts as a refugium for active ERVs, probably leading to female-biased mutational load that may influence female physiology similar to the ‘toxic-Y’ effect in Drosophila males. Furthermore, Haldane’s rule predicts that the heterogametic sex has reduced fertility in hybrids. We propose that the excess of W-linked active ERVs over the rest of the genome may be an additional explanatory variable for Haldane’s rule, with consequences for genetic incompatibilities between species through TE/repressor mismatches in hybrids. Together, our results suggest that the sequence content of female-specific W chromosomes can have effects far beyond sex determination and gene dosage.This article is part of the theme issue ‘Challenging the paradigm in sex chromosome evolution: empirical and theoretical insights with a focus on vertebrates (Part II)’.
Ämnesord
- NATURVETENSKAP -- Biologi -- Evolutionsbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Evolutionary Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
Nyckelord
- transposable element
- endogenous retrovirus
- transcriptome
- sex chromosome
- W chromosome
- Haldane's rule
- Ecosystems and species history
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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