SwePub
Sök i LIBRIS databas

  Extended search

L773:1420 9071 OR L773:1420 682X
 

Search: L773:1420 9071 OR L773:1420 682X > Immune cells lackin...

  • Dumanski, Jan P.Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik,Medical University of Gdańsk (author)

Immune cells lacking Y chromosome show dysregulation of autosomal gene expression

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2021-04-10
  • Springer,2021
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-443567
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-443567URI
  • https://doi.org/10.1007/s00018-021-03822-wDOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:146400327URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Hanna Davies, Edyta Rychlicka-Buniowska, Jonas Mattisson and Behrooz Torabi Moghadam contributed equally to this work
  • Epidemiological investigations show that mosaic loss of chromosome Y (LOY) in leukocytes is associated with earlier mortality and morbidity from many diseases in men. LOY is the most common acquired mutation and is associated with aberrant clonal expansion of cells, yet it remains unclear whether this mosaicism exerts a direct physiological effect. We studied DNA and RNA from leukocytes in sorted- and single-cells in vivo and in vitro. DNA analyses of sorted cells showed that men diagnosed with Alzheimer’s disease was primarily affected with LOY in NK cells whereas prostate cancer patients more frequently displayed LOY in CD4 + T cells and granulocytes. Moreover, bulk and single-cell RNA sequencing in leukocytes allowed scoring of LOY from mRNA data and confirmed considerable variation in the rate of LOY across individuals and cell types. LOY-associated transcriptional effect (LATE) was observed in ~ 500 autosomal genes showing dysregulation in leukocytes with LOY. The fraction of LATE genes within specific cell types was substantially larger than the fraction of LATE genes shared between different subsets of leukocytes, suggesting that LOY might have pleiotropic effects. LATE genes are involved in immune functions but also encode proteins with roles in other diverse biological processes. Our findings highlight a surprisingly broad role for chromosome Y, challenging the view of it as a “genetic wasteland”, and support the hypothesis that altered immune function in leukocytes could be a mechanism linking LOY to increased risk for disease.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Halvardson, Jonatan,1982-Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik(Swepub:uu)jonha894 (author)
  • Davies, HannaUppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik(Swepub:uu)handa349 (author)
  • Rychlicka-Buniowska, Edyta (author)
  • Mattisson, JonasUppsala universitet,Medicinsk genetik och genomik,Science for Life Laboratory, SciLifeLab(Swepub:uu)jonma819 (author)
  • Torabi Moghadam, BehroozUppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik(Swepub:uu)behto381 (author)
  • Nagy, NoemiKarolinska Institutet (author)
  • Węglarczyk, Kazimierz (author)
  • Bukowska-Strakova, Karolina (author)
  • Danielsson, MarcusUppsala universitet,Medicinsk genetik och genomik,Science for Life Laboratory, SciLifeLab(Swepub:uu)marda231 (author)
  • Olszewski, Paweł (author)
  • Piotrowski, Arkadiusz (author)
  • Oerton, Erin (author)
  • Forsberg, Lars A.,1974-Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik(Swepub:uu)larfo354 (author)
  • Przewoźnik, Marcin (author)
  • Bełch, Łukasz (author)
  • Grodzicki, Tomasz (author)
  • Chłosta, Piotr L. (author)
  • Imreh, Stefan (author)
  • Giedraitis, VilmantasUppsala universitet,Geriatrik(Swepub:uu)vigie517 (author)
  • Kilander, LenaUppsala universitet,Geriatrik(Swepub:uu)lekil226 (author)
  • Nordlund, JessicaUppsala universitet,Molekylär medicin(Swepub:uu)jesno775 (author)
  • Ameur, AdamUppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)adame789 (author)
  • Gyllensten, UlfUppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik(Swepub:uu)ulfgyll (author)
  • Johansson, ÅsaUppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik(Swepub:uu)asjoh108 (author)
  • Józkowicz, Alicja (author)
  • Siedlar, Maciej (author)
  • Klich-Rączka, Alicja (author)
  • Jaszczyński, Janusz (author)
  • Enroth, Stefan,1976-Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik(Swepub:uu)stenr451 (author)
  • Baran, Jarosław (author)
  • Ingelsson, MartinUppsala universitet,Geriatrik(Swepub:uu)maing121 (author)
  • Perry, John R. B. (author)
  • Ryś, Janusz (author)
  • Forsberg, Lars A.,1974-Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik(Swepub:uu)larfo354 (author)
  • Belch, L (author)
  • Uppsala universitetScience for Life Laboratory, SciLifeLab (creator_code:org_t)

Related titles

  • In:Cellular and Molecular Life Sciences (CMLS): Springer78:8, s. 4019-40331420-682X1420-9071

Internet link

Find in a library

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view