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Bisphenol A Inhibit...
Bisphenol A Inhibits the Transporter Function of the Blood-Brain Barrier by Directly Interacting with the ABC Transporter Breast Cancer Resistance Protein (BCRP)
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- Engdahl, Elin (författare)
- Uppsala universitet,Miljötoxikologi,Environmental Toxicology, Department of Organismal Biology, Uppsala University, 75236 Uppsala, Sweden
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- van Schijndel, Maarten D. M. (författare)
- Uppsala universitet,Miljötoxikologi,Environmental Toxicology, Department of Organismal Biology, Uppsala University, 75236 Uppsala, Sweden
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- Voulgaris, Dimitrios, 1990- (författare)
- KTH,Mikro- och nanosystemteknik,Division of Micro and Nanosystems, Department of Intelligent Systems, KTH Royal Institute of Technology, 11428 Stockholm, Sweden; AIMES, Department of Neuroscience, Karolinska Institute, 17177 Solna, Sweden
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- Di Criscio, Michela (författare)
- Uppsala universitet,Miljötoxikologi,Environmental Toxicology, Department of Organismal Biology, Uppsala University, 75236 Uppsala, Sweden
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- Ramsbottom, Kerry A. (författare)
- Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 3BX, UK ; Computational Biology Facility, Technology Directorate, University of Liverpool, Liverpool L69 3BX, UK
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- Rigden, Daniel J. (författare)
- Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 3BX, UK ; Computational Biology Facility, Technology Directorate, University of Liverpool, Liverpool L69 3BX, UK
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- Herland, Anna (författare)
- Karolinska Institutet,KTH,Mikro- och nanosystemteknik,Division of Micro and Nanosystems, Department of Intelligent Systems, KTH Royal Institute of Technology, 11428 Stockholm, Sweden; AIMES, Department of Neuroscience, Karolinska Institute, 17177 Solna, Sweden
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- Rüegg, Joëlle (författare)
- Uppsala universitet,Miljötoxikologi,Environmental Toxicology, Department of Organismal Biology, Uppsala University, 75236 Uppsala, Sweden
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(creator_code:org_t)
- 2021-05-24
- 2021
- Engelska.
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Ingår i: International Journal of Molecular Sciences. - : MDPI. - 1661-6596 .- 1422-0067. ; 22:11
- Relaterad länk:
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https://doi.org/10.3...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- The breast cancer resistance protein (BCRP) is an important efflux transporter in the blood-brain barrier (BBB), protecting the brain from a wide range of substances. In this study, we investigated if BCRP function is affected by bisphenol A (BPA), a high production volume chemical used in common consumer products, as well as by bisphenol F (BPF) and bisphenol S (BPS), which are used to substitute BPA. We employed a transwell-based in vitro cell model of iPSC-derived brain microvascular endothelial cells, where BCRP function was assessed by measuring the intracellular accumulation of its substrate Hoechst 33342. Additionally, we used in silico modelling to predict if the bisphenols could directly interact with BCRP. Our results showed that BPA significantly inhibits the transport function of BCRP. Additionally, BPA was predicted to bind to the cavity that is targeted by known BCRP inhibitors. Taken together, our findings demonstrate that BPA inhibits BCRP function in vitro, probably by direct interaction with the transporter. This effect might contribute to BPA's known impact on neurodevelopment.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
Nyckelord
- ABCG2
- BBB
- BCRP
- BPA
- BPF
- BPS
- bisphenols
- blood-brain barrier
- breast cancer resistance protein
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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