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Primary small intes...
Primary small intestinal neuroendocrine tumors are highly prevalent and often multiple before metastatic disease develops
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- Eriksson, John (author)
- Uppsala universitet,Endokrinkirurgi
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- Norlén, Olov (author)
- Uppsala universitet,Endokrinkirurgi
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- Ögren, M. (author)
- Uppsala universitet,Endokrinkirurgi,Uppsala Univ Hosp, Dept Surg Sci, Uppsala, Sweden.
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- Garmo, H. (author)
- Kings Coll London, Div Canc Studies, Res Oncol, Canc Epidemiol Grp, London, England.;Uppsala Univ, Reg Oncol Ctr, Uppsala, Sweden.
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- Ihre-Lundgren, C. (author)
- Karolinska Institutet
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- Hellman, Per (author)
- Uppsala universitet,Endokrinkirurgi
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(creator_code:org_t)
- 2019-10-07
- 2021
- English.
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In: Scandinavian Journal of Surgery. - : Sage Publications. - 1457-4969 .- 1799-7267. ; 110:1, s. 44-50
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Abstract
Subject headings
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- Background: Small intestinal neuroendocrine tumors are the most common of small bowel malignancies with a clinical incidence of about 1 per 100,000 persons per year. There has been a threefold increase in the incidence of small intestinal neuroendocrine tumor during later decades, but there are no studies that clarify whether this is due to a true higher incidence or if the rise is a mere product of, for instance, improved diagnostic modalities. The aim of this study was to investigate the incidence of clinical as well as subclinical small intestinal neuroendocrine tumors found at autopsy as well as describing the frequency of concomitant malignancies in patients with small intestinal neuroendocrine tumor. Materials and methods: An autopsy registry from the Malmo county population from 1970 to 1982 with an 87% autopsy rate was used. The clinical autopsy reports for patients coded for the existence of "carcinoid tumor" were scrutinized for the presence of small intestinal neuroendocrine tumor, metastatic disease, and concomitant malignancies. Details of patients with clinically diagnosed small intestinal neuroendocrine tumor during this time period were gathered from the Swedish Cancer Registry. Results: The mean annual incidence of small intestinal neuroendocrine tumor during this period was 5.33 per 100,000 individuals, and the mean annual prevalence was 581 per 100,000. The cause of death in the majority of cases was not due to small intestinal neuroendocrine tumor. In total, 48% of the people with small intestinal neuroendocrine tumor had at least one other malignancy, most commonly colorectal cancer. Conclusion: Most small intestinal neuroendocrine tumors are subclinical, and persons living with them will often die due to other causes. There was a high rate of multiple primary tumors (40%), suggesting that multiple tumors seem to arise before the advent of metastatic disease. Moreover, a comparably high rate of associated colorectal carcinoma was found.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Keyword
- Small intestinal neuroendocrine tumor
- epidemiology
- incidence
- midgut carcinoid
- neuroendocrine tumor
- multiple primaries
Publication and Content Type
- ref (subject category)
- art (subject category)
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