n-3 Fatty Acid Biomarkers and Incident Type 2 Diabetes: An Individual Participant-Level Pooling Project of 20 Prospective Cohort Studies

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n-3 Fatty Acid Biomarkers and Incident Type 2 Diabetes : An Individual Participant-Level Pooling Project of 20 Prospective Cohort Studies

Qian, Frank (författare): Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.;Harvard Med Sch, Dept Med, Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA.

Korat, Andres V. Ardisson (författare): Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA.

Imamura, Fumiaki (författare): Univ Cambridge, MRC Epidemiol Unit, Sch Clin Med, Cambridge, England.

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Marklund, Matti (författare): Uppsala universitet,Klinisk nutrition och metabolism,Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA.;Univ New South Wales, Fac Med, George Inst Global Hlth, Sydney, NSW, Australia.

Tintle, Nathan (författare): Dordt Univ, Dept Math & Stat, Sioux Ctr, SD USA.;Fatty Acid Res Inst, Sioux Falls, SD USA.

Virtanen, Jyrki K. (författare): Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.

Zhou, Xia (författare): Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA.

Bassett, Julie K. (författare): Canc Council Victoria, Melbourne, Vic, Australia.

Lai, Heidi (författare): Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA.;Imperial Coll London, London, England.

Hirakawa, Yoichiro (författare): Kyushu Univ, Grad Sch Med Sci, Dept Med & Clin Sci, Fukuoka, Japan.

Chien, Kuo-Liong (författare): Natl Taiwan Univ, Coll Publ Hlth, Inst Epidemiol & Prevent Med, Taipei, Taiwan.;Natl Taiwan Univ Hosp, Dept Internal Med, Taipei, Taiwan.

Wood, Alexis C. (författare): USDA ARS, Childrens Nutr Res Ctr, Houston, TX USA.

Lankinen, Maria (författare): Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.

Murphy, Rachel A. (författare): Univ British Columbia, Vancouver, BC, Canada.

Samieri, Cecilia (författare): Univ Bordeaux, Bordeaux Populat Hlth Res Ctr, INSERM, UMR 1219, Bordeaux, France.

Pertiwi, Kamalita (författare): Wageningen Univ, Div Human Nutr, Wageningen, Netherlands.

de Mello, Vanessa D. (författare): Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.

Guan, Weihua (författare): Univ Minnesota, Div Biostat, Minneapolis, MN USA.

Forouhi, Nita G. (författare): Univ Cambridge, MRC Epidemiol Unit, Sch Clin Med, Cambridge, England.

Wareham, Nick (författare): Univ Cambridge, MRC Epidemiol Unit, Sch Clin Med, Cambridge, England.

Hu, Frank B. (författare)

Risérus, Ulf, 1967- (författare): Uppsala universitet,Klinisk nutrition och metabolism

Lind, Lars (författare): Uppsala universitet,Klinisk nutrition och metabolism,Klinisk epidemiologi

Harris, William S. (författare): Fatty Acid Res Inst, Sioux Falls, SD USA.;Univ South Dakota, Sanford Sch Med, Dept Internal Med, Sioux Falls, SD USA.

Shadyab, Aladdin H. (författare): Univ Calif San Diego, Sch Med, Dept Family Med & Publ Hlth, La Jolla, CA 92093 USA.

Robinson, Jennifer G. (författare): Univ Iowa, Dept Epidemiol, Iowa City, IA USA.;Univ Iowa, Dept Med, Iowa City, IA 52242 USA.

Steffen, Lyn M. (författare): Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.

Hodge, Allison (författare): Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA.;Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne, Vic, Australia.

Giles, Graham G. (författare): Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA.;Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne, Vic, Australia.;Monash Univ, Sch Clin Sci, Precis Med, Monash Hlth, Clayton, Vic, Australia.

Ninomiya, Toshiharu (författare): Kyushu Univ, Grad Sch Med Sci, Dept Epidemiol & Publ Hlth, Fukuoka, Japan.;Kyushu Univ, Ctr Cohort Studies, Grad Sch Med Sci, Fukuoka, Japan.

Uusitupa, Matti (författare): Fatty Acid Res Inst, Sioux Falls, SD USA.

Tuomilehto, Jaakko (författare): Finnish Inst Hlth & Welf, Publ Hlth Promot Unit, Helsinki, Finland.;King Abdulaziz Univ, Diabet Res Grp, Jeddah, Saudi Arabia.

Lindstrom, Jaana (författare): Finnish Inst Hlth & Welf, Publ Hlth Promot Unit, Helsinki, Finland.

Laakso, Markku (författare): Univ Eastern Finland, Inst Clin Med, Kuopio, Finland.

Siscovick, David S. (författare): New York Acad Med, New York, NY USA.

Helmer, Catherine (författare): Univ British Columbia, Vancouver, BC, Canada.

Geleijnse, Johanna M. (författare): Univ Bordeaux, Bordeaux Populat Hlth Res Ctr, INSERM, UMR 1219, Bordeaux, France.

Wu, Jason H. Y. (författare): Univ New South Wales, Fac Med, George Inst Global Hlth, Sydney, NSW, Australia.

Fretts, Amanda (författare): Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA.

Lemaitre, Rozenn N. (författare): Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA.

Micha, Renata (författare): Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA.

Mozaffarian, Dariush (författare): Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA.;Tufts Med Ctr, Div Cardiol, Boston, MA 02111 USA.

Sun, Qi (författare): Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA.

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Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA;Harvard Med Sch, Dept Med, Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA. Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA. (creator_code:org_t)

2021-03-03
2021
Engelska.
Ingår i: Diabetes Care. - : American Diabetes Association. - 0149-5992 .- 1935-5548. ; 44:5, s. 1133-1142

Relaterad länk:: https://care.diabete...; visa fler...; https://urn.kb.se/re...; https://doi.org/10.2...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

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OBJECTIVE Prospective associations between n-3 fatty acid biomarkers and type 2 diabetes (T2D) risk are not consistent in individual studies. We aimed to summarize the prospective associations of biomarkers of alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA) with T2D risk through an individual participant-level pooled analysis.RESEARCH DESIGN AND METHODS For our analysis we incorporated data from a global consortium of 20 prospective studies from 14 countries. We included 65,147 participants who had blood measurements of ALA, EPA, DPA, or DHA and were free of diabetes at baseline. De novo harmonized analyses were performed in each cohort following a pre-specified protocol, and cohort-specific associations were pooled using inverse variance-weighted meta-analysis.RESULTS A total of 16,693 incident T2D cases were identified during follow-up (median follow-up ranging from 2.5 to 21.2 years). In pooled multivariable analysis, per interquintile range (difference between the 90th and 10th percentiles for each fatty acid), EPA, DPA, DHA, and their sum were associated with lower T2D incidence, with hazard ratios (HRs) and 95% CIs of 0.92 (0.87, 0.96), 0.79 (0.73, 0.85), 0.82 (0.76, 0.89), and 0.81 (0.75, 0.88), respectively (all P < 0.001). ALA was not associated with T2D (HR 0.97 [95% CI 0.92, 1.02]) per interquintile range. Associations were robust across prespecified subgroups as well as in sensitivity analyses.CONCLUSIONS Higher circulating biomarkers of seafood-derived n-3 fatty acids, including EPA, DPA, DHA, and their sum, were associated with lower risk of T2D in a global consortium of prospective studies. The biomarker of plant-derived ALA was not significantly associated with T2D risk.

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Av författaren/redakt...: Qian, Frank; Korat, Andres V. ...; Imamura, Fumiaki; Marklund, Matti; Tintle, Nathan; Virtanen, Jyrki ...; visa fler...; Zhou, Xia; Bassett, Julie K ...; Lai, Heidi; Hirakawa, Yoichi ...; Chien, Kuo-Liong; Wood, Alexis C.; Lankinen, Maria; Murphy, Rachel A ...; Samieri, Cecilia; Pertiwi, Kamalit ...; de Mello, Vaness ...; Guan, Weihua; Forouhi, Nita G.; Wareham, Nick; Hu, Frank B.; Risérus, Ulf, 19 ...; Lind, Lars; Harris, William ...; Shadyab, Aladdin ...; Robinson, Jennif ...; Steffen, Lyn M.; Hodge, Allison; Giles, Graham G.; Ninomiya, Toshih ...; Uusitupa, Matti; Tuomilehto, Jaak ...; Lindstrom, Jaana; Laakso, Markku; Siscovick, David ...; Helmer, Catherin ...; Geleijnse, Johan ...; Wu, Jason H. Y.; Fretts, Amanda; Lemaitre, Rozenn ...; Micha, Renata; Mozaffarian, Dar ...; Sun, Qi; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Endokrinologi oc ...

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Av lärosätet: Uppsala universitet

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n-3 Fatty Acid Biomarkers and Incident Type 2 Diabetes : An Individual Participant-Level Pooling Project of 20 Prospective Cohort Studies

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