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Sökning: (WFRF:(Frisell Jan)) > (2020-2024) > Quality assessment ...

Quality assessment of radiotherapy in the prospective randomized SENOMAC trial

Alkner, Sara (författare)
Department of Oncology, Faculty of Medicine, Institute of Clinical Sciences Lund, Lund University, Lund, Sweden; Skåne University Hospital Lund, Department of Hematology, Oncology and Radiation Physics, Lund, Sweden
Wieslander, Elinore (författare)
Skåne University Hospital Lund, Department of Hematology, Oncology and Radiation Physics, Lund, Sweden
Lundstedt, Dan (författare)
Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden; Department of Oncology at, Sahlgrenska University Hospital, Gothenburg, Sweden
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Berg, Martin (författare)
Department of Oncology, Vejle Hospital, University Hospital of Southern Denmark, Vejle, Denmark
Kristensen, Ingrid (författare)
Skåne University Hospital Lund, Department of Hematology, Oncology and Radiation Physics, Lund, Sweden
Andersson, Yvette (författare)
Department of Surgery, Vastmanland Hospital Västerås, Västerås, Sweden; Centre for Clinical Research, Uppsala University and Region Vastmanland, Vastmanland Hospital Västerås, Sweden
Bergkvist, Leif (författare)
Centre for Clinical Research, Uppsala University and Region Vastmanland, Vastmanland Hospital Västerås, Sweden
Frisell, Jan (författare)
Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Breast Center Karolinska, Karolinska Comprehensive Cancer Center, Karolinska University Hospital, Stockholm, Sweden
Olofsson Bagge, Roger (författare)
Sahlgrenska Center for Cancer Research, Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Surgery, Sahlgrenska University Hospital, Gothenburg, Sweden; Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden
Sund, Malin (författare)
Umeå universitet,Institutionen för diagnostik och intervention,Kirurgi,Department of Surgery, University of Helsinki and Helsinki University Hospital, Finland
Christiansen, Peer (författare)
Department of Plastic and Breast Surgery, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
Davide Gentilini, Oreste (författare)
Breast Surgery, IRCCS Ospedale San Raffaele, Milano, Italy; Vita-Salute San Raffaele University, Milano, Italy
Kontos, Michalis (författare)
1st Department of Surgery, National and Kapodistrian University of Athens, Athens, Greece
Kühn, Thorsten (författare)
Die Filderklinik, Breast Center, Filderstadt, Germany; Department of Gynecology and Obstetrics, University of Ulm, Germany
Reimer, Toralf (författare)
Department of Obstetrics and Gynecology, University of Rostock, Rostock, Germany
Rydén, Lisa (författare)
Department of Oncology, Faculty of Medicine, Institute of Clinical Sciences Lund, Lund University, Lund, Sweden; Skåne University Hospital, Department of Gastroenterology and Surgery, Malmö, Sweden
Filtenborg Tvedskov, Tove (författare)
Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Breast Surgery, Gentofte Hospital, Gentofte, Denmark
Vrou Offersen, Birgitte (författare)
Department of Oncology, Aarhus University Hospital, Aarhus University, Aarhus, Denmark; Department of Experimental Clinical Oncology, Danish Center for Particle Therapy, Aarhus, Denmark
Dahl Nissen, Henrik (författare)
Department of Oncology, Vejle Hospital, University Hospital of Southern Denmark, Vejle, Denmark
de Boniface, Jana (författare)
Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Department of Surgery, Capio St. Goran's Hospital, Stockholm, Sweden
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 (creator_code:org_t)
2024
2024
Engelska.
Ingår i: Radiotherapy and Oncology. - 0167-8140 .- 1879-0887. ; 197
Relaterad länk:
https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Background and purpose: Recommendations for regional radiotherapy (RT) of sentinel lymph node (SLN)-positive breast cancer are debated. We here report a RT quality assessment of the SENOMAC trial.Materials and Methods: The SENOMAC trial randomized clinically node-negative breast cancer patients with 1–2 SLN macrometastases to completion axillary lymph node dissection (cALND) or SLN biopsy only between 2015–2021. Adjuvant RT followed national guidelines. RT plans for patients included in Sweden and Denmark until June 2019 were collected (N = 1176) and compared to case report forms (CRF). Dose to level I (N = 270) and the humeral head (N = 321) was analyzed in detail.Results: CRF-data and RT plans agreed in 99.3 % (breast/chest wall) and in 96.6 % of patients (regional RT). Congruence for whether level I was an intended RT target was lower (78 %). In accordance with Danish national guidelines, level I was more often an intended target in the SLN biopsy only arm (N = 334/611, 55 %,) than in the cALND arm (N = 174/565, 31 %,). When an intended target, level I received prescribed dose to 100 % (IQR 98–100 %) of the volume. However, even when not an intended target, full dose was delivered to > 80 % of level I (IQR 75–90 %). The intentional inclusion of level I in the target volume more than doubled the dose received by ≥ 50 % of the humeral head.Conclusion: Congruence between CRF data and RT plans was excellent. Level I received a high dose coverage even when not intentionally included in the target. Including level I in target significantly increased dose to the humeral head.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

(omission of) sentinel lymph node biopsy
Axillary treatment
Breast cancer
Incidental radiotherapy dose
Radiotherapy quality assurance
Radiotherapy techniques
Treatment planning

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