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  • Alarcon, SoniaUniv Miguel Hernandez Elche, Inst Bioingn, Elche, Alicante, Spain.;Karolinska Inst, Inst Environm Med, Stockholm, Sweden (författare)

Endocrine, metabolic and apical effects of in utero and lactational exposure to non-dioxin-like 2,2 ',3,4,4 ',5,5 '-heptachlorobiphenyl (PCB 180) : A postnatal follow-up study in rats

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • Elsevier,2021
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-447923
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-447923URI
  • https://doi.org/10.1016/j.reprotox.2021.04.004DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:146778306URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • PCB 180 is a persistent and abundant non-dioxin-like PCB (NDL-PCB). We determined the developmental toxicity profile of ultrapure PCB 180 in developing offspring following in utero and lactational exposure with the focus on endocrine, metabolic and retinoid system alterations. Pregnant rats were given total doses of 0, 10, 30, 100, 300 or 1000 mg PCB 180/kg bw on gestational days 7-10 by oral gavage, and the offspring were sampled on postnatal days (PND) 7, 35 and 84. Decreased serum testosterone and triiodothyronine concentrations on PND 84, altered liver retinoid levels, increased liver weights and induced 7-pentoxyresorufin O-dealkylase (PROD) activity were the sensitive effects used for margin of exposure (MoE) calculations. Liver weights were increased together with induction of the metabolizing enzymes cytochrome P450 (CYP) 2B1, CYP3A1, and CYP1A1. Less sensitive effects included decreased serum estradiol and increased luteinizing hormone levels in females, decreased prostate and seminal vesicle weight and increased pituitary weight in males, increased cortical bone area and thickness of tibial diaphysis in females and decreased cortical bone mineral density in males. Developmental toxicity profiles were partly different in male and female offspring, males being more sensitive to increased liver weight, PROD induction and decreased thyroxine concentrations. MoE assessment indicated that the 95th percentile of current maternal PCB 180 concentrations do not exceed the estimated tolerable human lipid-based PCB 180 concentration. Although PCB 180 is much less potent than dioxin-like compounds, it shares several toxicological targets suggesting a potential for interactions.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Esteban, JavierUniv Miguel Hernandez Elche, Inst Bioingn, Elche, Alicante, Spain (författare)
  • Roos, RobertKarolinska Inst, Inst Environm Med, Stockholm, Sweden.;Grand Duchy Luxembourg, Lab & Mine Inspect, Minist Work, Luxembourg, Luxembourg (författare)
  • Heikkinen, PaiviFinnish Inst Hlth & Welf THL, Environm Hlth Unit, POB 95, FI-70701 Kuopio, Finland (författare)
  • Sanchez-Perez, IsmaelUniv Miguel Hernandez Elche, Inst Bioingn, Elche, Alicante, Spain (författare)
  • Adamsson, AnnikaUniv Turku, Turku Univ Hosp, Inst Biomed, Dept Paediat,Res Ctr Integrat Physiol & Pharmac, FI-20520 Turku, Finland.;Univ Turku, Turku Univ Hosp, Inst Biomed, Dept Paediat,Ctr Populat Hlth Res, FI-20520 Turku, Finland,Univ Oulu, Fac Med, Res Unit Med Imaging Phys & Technol, Oulu, Finland,Vrije Univ Amsterdam, Dept Environm & Hlth, De Boelelaan 1108, NL-1081 HZ Amsterdam, Netherlands (författare)
  • Toppari, JormaUniv Turku, Turku Univ Hosp, Inst Biomed, Dept Paediat,Res Ctr Integrat Physiol & Pharmac, FI-20520 Turku, Finland.;Univ Turku, Turku Univ Hosp, Inst Biomed, Dept Paediat,Ctr Populat Hlth Res, FI-20520 Turku, Finland (författare)
  • Koskela, AnttiUniv Oulu, Inst Canc Res & Translat Med, Dept Anat & Cell Biol, Oulu, Finland (författare)
  • Finnila, Mikko A. J.Univ Oulu, Fac Med, Res Unit Med Imaging Phys & Technol, Oulu, Finland (författare)
  • Tuukkanen, JuhaUniv Oulu, Inst Canc Res & Translat Med, Dept Anat & Cell Biol, Oulu, Finland (författare)
  • Herlin, MariaKarolinska Inst, Inst Environm Med, Stockholm, Sweden (författare)
  • Hamscher, GerdJustus Liebig Univ, Inst Food Chem & Food Biotechnol, D-35392 Giessen, Germany (författare)
  • Leslie, Heather A.Vrije Univ Amsterdam, Dept Environm & Hlth, De Boelelaan 1108, NL-1081 HZ Amsterdam, Netherlands (författare)
  • Korkalainen, MerjaFinnish Inst Hlth & Welf THL, Environm Hlth Unit, POB 95, FI-70701 Kuopio, Finland (författare)
  • Halldin, KristerUppsala universitet,Institutionen för kemi - BMC,Karolinska Inst, Inst Environm Med, Stockholm, Sweden(Swepub:uu)krishall (författare)
  • Schrenk, DieterUniv Kaiserslautern, Food Chem & Toxicol, D-67663 Kaiserslautern, Germany (författare)
  • Hakansson, HelenKarolinska Institutet,Karolinska Inst, Inst Environm Med, Stockholm, Sweden (författare)
  • Viluksela, MattiUniv Eastern Finland, Sch Pharm Toxicol, Dept Environm & Biol Sci, Kuopio, Finland.;Uppsala Univ, BMC, Off Med & Pharm, SE-75123 Uppsala, Sweden (författare)
  • Univ Miguel Hernandez Elche, Inst Bioingn, Elche, Alicante, Spain.;Karolinska Inst, Inst Environm Med, Stockholm, SwedenUniv Miguel Hernandez Elche, Inst Bioingn, Elche, Alicante, Spain (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Reproductive Toxicology: Elsevier102, s. 109-1270890-62381873-1708

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