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Effect of the Expre...
Effect of the Expression of ELOVL5 and IGFBP6 Genes on the Metastatic Potential of Breast Cancer Cells
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- Nikulin, Sergey (författare)
- Natl Res Univ Higher Sch Econ, Fac Biol & Biotechnol, Moscow, Russia
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- Zakharova, Galina (författare)
- Sci Res Ctr Bioclinicum, Moscow, Russia
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- Poloznikov, Andrey (författare)
- Natl Res Univ Higher Sch Econ, Fac Biol & Biotechnol, Moscow, Russia; Far Eastern Fed Univ, Sch Biomed, Vladivostok, Russia
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- Raigorodskaya, Maria (författare)
- Natl Res Univ Higher Sch Econ, Fac Biol & Biotechnol, Moscow, Russia; Sci Res Ctr Bioclinicum, Moscow, Russia
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- Wicklein, Daniel (författare)
- Univ Med Ctr Hamburg Eppendorf, Inst Anat & Expt Morphol, Hamburg, Germany
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- Schumacher, Udo (författare)
- Univ Med Ctr Hamburg Eppendorf, Inst Anat & Expt Morphol, Hamburg, Germany
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- Nersisyan, Stepan (författare)
- Natl Res Univ Higher Sch Econ, Fac Biol & Biotechnol, Moscow, Russia
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- Bergquist, Jonas (författare)
- Uppsala universitet,Analytisk kemi
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- Bakalkin, Georgy (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Astakhova, Lidiia (författare)
- Sci Res Ctr Bioclinicum, Moscow, Russia; Immanuel Kant Baltic Fed Univ, Sch Life Sci, Kaliningrad, Russia
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- Tonevitsky, Alexander (författare)
- Natl Res Univ Higher Sch Econ, Fac Biol & Biotechnol, Moscow, Russia; Shemyakin Ovchinnikov Inst Bioorgan Chem RAS, Lab Microfluid Technol Biomed, Moscow, Russia
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(creator_code:org_t)
- 2021-06-02
- 2021
- Engelska.
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Ingår i: Frontiers in Genetics. - : Frontiers Media S.A.. - 1664-8021. ; 12
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://www.frontier...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Breast cancer (BC) is the leading cause of death from malignant neoplasms among women worldwide, and metastatic BC presents the biggest problems for treatment. Previously, it was shown that lower expression of ELOVL5 and IGFBP6 genes is associated with a higher risk of the formation of distant metastases in BC. In this work, we studied the change in phenotypical traits, as well as in the transcriptomic and proteomic profiles of BC cells as a result of the stable knockdown of ELOVL5 and IGFBP6 genes. The knockdown of ELOVL5 and IGFBP6 genes was found to lead to a strong increase in the expression of the matrix metalloproteinase (MMP) MMP1. These results were in good agreement with the correlation analysis of gene expression in tumor samples from patients and were additionally confirmed by zymography. The knockdown of ELOVL5 and IGFBP6 genes was also discovered to change the expression of a group of genes involved in the formation of intercellular contacts. In particular, the expression of the CDH11 gene was markedly reduced, which also complies with the correlation analysis. The spheroid formation assay showed that intercellular adhesion decreased as a result of the knockdown of the ELOVL5 and IGFBP6 genes. Thus, the obtained data indicate that malignant breast tumors with reduced expression of the ELOVL5 and IGFBP6 genes can metastasize with a higher probability due to a more efficient invasion of tumor cells.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- breast cancer
- ELOVL5
- IGFBP6
- matrix metalloproteinases
- cell-cell contacts
- MDA-MB-231
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- art (ämneskategori)
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Nikulin, Sergey
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Zakharova, Galin ...
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Poloznikov, Andr ...
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Raigorodskaya, M ...
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Wicklein, Daniel
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Schumacher, Udo
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Nersisyan, Stepa ...
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Bergquist, Jonas
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Bakalkin, Georgy
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Astakhova, Lidii ...
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Tonevitsky, Alex ...
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