SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:DiVA.org:uu-448916"
 

Sökning: onr:"swepub:oai:DiVA.org:uu-448916" > Indoor bacterial, f...

  • Fu, XiSouth China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr O, Guangzhou 510642, Guangdong, Peoples R China; Sun Yat Sen Univ, Sch Publ Hlth, Guangzhou, Peoples R China (författare)

Indoor bacterial, fungal and viral species and functional genes in urban and rural schools in Shanxi Province, China : association with asthma, rhinitis and rhinoconjunctivitis in high school students

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • 2021-06-12
  • Springer Nature,2021
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-448916
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-448916URI
  • https://doi.org/10.1186/s40168-021-01091-0DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • BackgroundStudies in developed countries have reported that the prevalence of asthma and rhinitis is higher in urban areas than in rural areas, and this phenomenon is associated with urbanization and changing indoor microbiome exposure. Developing countries such as China have experienced rapid urbanization in past years, but no study has investigated microbiome exposure and urban-rural health effects in these countries.MethodsNine high schools from urban and rural areas were randomly selected in Shanxi Province, China, and classroom vacuum dust was collected for shotgun metagenomic sequencing. A self-administered questionnaire was collected from 1332 students for personal information and health data. Three-level logistic regression was performed between microbial richness/abundance/functional pathways and the occurrence of asthma and rhinitis symptoms.ResultsConsistent with developed countries, the prevalence of wheeze and rhinitis was higher in urban areas than in rural areas (p < 0.05). Metagenomic profiling revealed 8302 bacterial, 395 archaeal, 744 fungal, 524 protist and 1103 viral species in classroom dust. Actinobacteria (mean relative abundance 49.7%), Gammaproteobacteria (18.4%) and Alphaproteobacteria (10.0%) were the most abundant bacterial classes. The overall microbiome composition was significantly different between urban and rural schools (p = 0.001, Adonis). Species from Betaproteobactera, Gammaproteobacteria and Bacilli were enriched in urban schools, and species from Actinobacteria and Cyanobacteria were enriched in rural schools. Potential pathogens were present in higher abundance in urban schools than in rural schools (p < 0.05). Pseudoalteromonas, Neospora caninum and Microbacterium foliorum were positively associated with the occurrence of wheeze, rhinitis and rhinoconjunctivitis, and Brachybacterium was protectively (negatively) associated with rhinitis (p < 0.01). The abundance of human endocrine and metabolic disease pathways was positively associated with rhinitis (p = 0.008), and butyrate and propionate metabolic genes and pathways were significantly enriched in rural schools (p < 0.005), in line with previous findings that these short-chain fatty acids protect against inflammatory diseases in the human gut.ConclusionsWe conducted the first indoor microbiome survey in urban/rural environments with shotgun metagenomics, and the results revealed high-resolution microbial taxonomic and functional profiling and potential health effects.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Ou, ZheyuanSouth China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr O, Guangzhou 510642, Guangdong, Peoples R China; South China Agr Univ, Minist Agr & Rural Affairs, Key Lab Zoonosis, Guangzhou 510642, Guangdong, Peoples R China; South China Agr Univ, Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China (författare)
  • Zhang, MeiSouth China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr O, Guangzhou 510642, Guangdong, Peoples R China; South China Agr Univ, Minist Agr & Rural Affairs, Key Lab Zoonosis, Guangzhou 510642, Guangdong, Peoples R China; South China Agr Univ, Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China (författare)
  • Meng, YiSouth China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr O, Guangzhou 510642, Guangdong, Peoples R China; South China Agr Univ, Minist Agr & Rural Affairs, Key Lab Zoonosis, Guangzhou 510642, Guangdong, Peoples R China; South China Agr Univ, Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China (författare)
  • Li, YanlingSouth China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr O, Guangzhou 510642, Guangdong, Peoples R China; South China Agr Univ, Minist Agr & Rural Affairs, Key Lab Zoonosis, Guangzhou 510642, Guangdong, Peoples R China; South China Agr Univ, Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China (författare)
  • Wen, JikaiSouth China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr O, Guangzhou 510642, Guangdong, Peoples R China; South China Agr Univ, Minist Agr & Rural Affairs, Key Lab Zoonosis, Guangzhou 510642, Guangdong, Peoples R China; South China Agr Univ, Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China (författare)
  • Hu, QianshengSun Yat Sen Univ, Sch Publ Hlth, Guangzhou, Peoples R China (författare)
  • Zhang, XinShanxi Univ, Inst Environm Sci, Taiyuan, Peoples R China (författare)
  • Norbäck, DanUppsala universitet,Arbets- och miljömedicin(Swepub:uu)dagnorba (författare)
  • Deng, YiqunSouth China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr O, Guangzhou 510642, Guangdong, Peoples R China; South China Agr Univ, Minist Agr & Rural Affairs, Key Lab Zoonosis, Guangzhou 510642, Guangdong, Peoples R China; South China Agr Univ, Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China (författare)
  • Zhao, ZhuohuiFudan Univ, Shanghai Typhoon Inst, NHC Key Lab Hlth Technol As, Sch Publ Hlth, CMA, Shanghai Key Lab Meteorol & Hlt, Dept Environm Hlth, Minist Educ, Key Lab Publ Hlth, Shanghai 200030, Peoples R China (författare)
  • Sun, YuSouth China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr O, Guangzhou 510642, Guangdong, Peoples R China; South China Agr Univ, Minist Agr & Rural Affairs, Key Lab Zoonosis, Guangzhou 510642, Guangdong, Peoples R China; South China Agr Univ, Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China (författare)
  • South China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr O, Guangzhou 510642, Guangdong, Peoples R China; Sun Yat Sen Univ, Sch Publ Hlth, Guangzhou, Peoples R ChinaSouth China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr O, Guangzhou 510642, Guangdong, Peoples R China; South China Agr Univ, Minist Agr & Rural Affairs, Key Lab Zoonosis, Guangzhou 510642, Guangdong, Peoples R China; South China Agr Univ, Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Microbiome: Springer Nature9:12049-2618

Internetlänk

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy