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  • Shahcheraghi, Seyed HosseinShahid Sadoughi Univ Med Sci, Shahid Sadoughi Hosp, Infect Dis Res Ctr, Yazd, Iran; Shahid Sadoughi Univ Med Sci, Sch Med, Dept Med Genet, Yazd, Iran (author)

Overview of key molecular and pharmacological targets for diabetes and associated diseases

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • Elsevier,2021
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-448999
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-448999URI
  • https://doi.org/10.1016/j.lfs.2021.119632DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Diabetes epidemiological quantities are demonstrating one of the most important communities' health worries. The essential diabetic difficulties are including cardiomyopathy, nephropathy, inflammation, and retinopathy. Despite developments in glucose decreasing treatments and drugs, these diabetic complications are still ineffectively reversed or prohibited. Several signaling and molecular pathways are vital targets in the new therapies of diabetes. This review assesses the newest researches about the key molecules and signaling pathways as targets of molecular pharmacology in diabetes and diseases related to it for better treatment based on molecular sciences. The disease is not cured by current pharmacological strategies for type 2 diabetes. While several drug combinations are accessible that can efficiently modulate glycemia and mitigate long-term complications, these agents do not reverse pathogenesis, and in practice, they are not established to modify the patient's specific molecular profiling. Therapeutic companies have benefited from human genetics. Genome exploration, which is agnostic to the information that exists, has revealed tens of loci that impact glycemic modulation. The physiological report has begun to examine subtypes of diseases, illustrate heterogeneity and propose biochemical therapeutic pathways.

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  • Aljabali, Alaa A. A.Yarmouk Univ, Dept Pharmaceut & Pharmaceut Technol, Irbid, Jordan (author)
  • Al Zoubi, Mazhar S.Yarmouk Univ, Fac Med, Dept Basic Med Sci, Irbid, Jordan (author)
  • Mishra, VijayLovely Profess Univ, Sch Pharmaceut Sci, Phagwara 144411, Punjab, India (author)
  • Charbe, Nitin B.Texas A&M Hlth Sci Ctr, Irma Lerma Rangel Coll Pharm, Dept Pharmaceut Sci, Kingsville, TX 78363 USA (author)
  • Haggag, Yusuf A.Tanta Univ, Fac Pharm, Dept Pharmaceut Technol, Tanta, Egypt (author)
  • Shrivastava, GarimaIndian Inst Technol, Delhi, India (author)
  • Almutary, Abdulmajeed G.Qassim Univ, Coll Appl Med Sci, Dept Med Biotechnol, Buraydah, Saudi Arabia (author)
  • Alnuqaydan, Abdullah M.Qassim Univ, Coll Appl Med Sci, Dept Med Biotechnol, Buraydah, Saudi Arabia (author)
  • Barh, DebmalyaInst Integrat Omics & Appl, Ctr Genom & Appl Gene Technol, Purba Medinipur, W Bengal, India (author)
  • Dua, KamalUniv Technol Sydney, Grad Sch Hlth, Discipline Pharm, Ultimo, NSW 2007, Australia (author)
  • Chellappan, Dinesh K.Int Med Univ, Sch Pharm, Dept Life Sci, Kuala Lumpur, Malaysia (author)
  • Gupta, GauravSuresh Gyan Vihar Univ, Sch Pharm, Mahal Rd, Jaipur, Rajasthan, India (author)
  • Lotfi, MarziehShahid Sadoughi Univ Med Sci, Abort Res Ctr, Reprod Sci Inst, Yazd, Iran (author)
  • Serrano-Aroca, ÁngelCatholic Univ Valencia San Vicente M Rtir, Translat Res Ctr San Alberto Magno, Biomat & Bioengn Lab, C Guillem de Castro 94, Valencia 46001, Spain (author)
  • Bahar, BojlulUniv Cent Lancashire, Res Ctr Global Dev, Sch Sport & Hlth Sci, Nutr Sci & Appl Food Safety Studies, Preston PR1 2HE, Lancs, England (author)
  • Mishra, Yogendra KumarUniv Southern Denmark, Mads Clausen Inst, NanoSYD, Alsion 2, DK-6400 Sønderborg, Denmark (author)
  • Takayama, KazuoKyoto Univ, Ctr IPS Cell Res & Applicat, Kyoto 6068397, Japan (author)
  • Panda, Pritam Kumar,PhD Student,1991-Uppsala universitet,Materialteori(Swepub:uu)pripa793 (author)
  • Bakshi, Hamid A.Ulster Univ, Sch Pharm & Pharmaceut Sci, Coleraine BT52 1SA, Londonderry, North Ireland (author)
  • Tambuwala, Murtaza M.Ulster Univ, Sch Pharm & Pharmaceut Sci, Coleraine BT52 1SA, Londonderry, North Ireland (author)
  • Shahid Sadoughi Univ Med Sci, Shahid Sadoughi Hosp, Infect Dis Res Ctr, Yazd, Iran; Shahid Sadoughi Univ Med Sci, Sch Med, Dept Med Genet, Yazd, IranYarmouk Univ, Dept Pharmaceut & Pharmaceut Technol, Irbid, Jordan (creator_code:org_t)

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  • In:Life Sciences: Elsevier2780024-32051879-0631

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