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Upregulation of VCA...
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Arasa, JorgeSwiss Fed Inst Technol, Inst Pharmaceut Sci, Zurich, Switzerland.
(author)
Upregulation of VCAM-1 in lymphatic collectors supports dendritic cell entry and rapid migration to lymph nodes in inflammation
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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2021-05-14
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Rockefeller University Press,2021
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-449342
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-449342URI
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https://doi.org/10.1084/jem.20201413DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Dendritic cell (DC) migration to draining lymph nodes (dLNs) is a slow process that is believed to begin with DCs approaching and entering into afferent lymphatic capillaries. From capillaries, DCs slowly crawl into lymphatic collectors, where lymph flow induced by collector contraction supports DC detachment and thereafter rapid, passive transport to dLNs. Performing a transcriptomics analysis of dermal endothelial cells, we found that inflammation induces the degradation of the basement membrane (BM) surrounding lymphatic collectors and preferential up-regulation of the DC trafficking molecule VCAM-1 in collectors. In crawl-in experiments performed in ear skin explants, DCs entered collectors in a CCR7- and beta 1 integrin-dependent manner. In vivo, loss of beta 1-integrins in DCs or of VCAM-1 in lymphatic collectors had the greatest impact on DC migration to dLNs at early time points when migration kinetics favor the accumulation of rapidly migrating collector DCs rather than slower capillary DCs. Taken together, our findings identify collector entry as a critical mechanism enabling rapid DC migration to dLNs in inflammation.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Collado-Diaz, VictorSwiss Fed Inst Technol, Inst Pharmaceut Sci, Zurich, Switzerland.
(author)
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Kritikos, IoannisSwiss Fed Inst Technol, Inst Pharmaceut Sci, Zurich, Switzerland.
(author)
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Medina-Sanchez, Jessica DaniellySwiss Fed Inst Technol, Inst Pharmaceut Sci, Zurich, Switzerland.
(author)
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Friess, Mona CarinaSwiss Fed Inst Technol, Inst Pharmaceut Sci, Zurich, Switzerland.
(author)
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Sigmund, Elena CarolineSwiss Fed Inst Technol, Inst Pharmaceut Sci, Zurich, Switzerland.
(author)
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Schineis, PhilippSwiss Fed Inst Technol, Inst Pharmaceut Sci, Zurich, Switzerland.
(author)
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Hunter, Morgan CampbellSwiss Fed Inst Technol, Inst Pharmaceut Sci, Zurich, Switzerland.
(author)
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Tacconi, CarlottaSwiss Fed Inst Technol, Inst Pharmaceut Sci, Zurich, Switzerland.
(author)
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Paterson, NeilMax Planck Inst Immunobiol & Epigenet, Freiburg, Germany.;Univ Freiburg, Fac Biol, Freiburg, Germany.;Int Max Planck Res Sch Immunobiol Epigenet & Meta, Freiburg, Germany.
(author)
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Nagasawa, TakashiOsaka Univ, Grad Sch Frontier Biosci, Lab Stem Cell Biol & Dev Immunol, Osaka, Japan.;Osaka Univ, Grad Sch Med, Osaka, Japan.
(author)
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Kiefer, FriedemannMax Planck Inst Mol Biomed, Munster, Germany.;Westfalische Wilhelms Univ Munster, European Inst Mol Imaging, Munster, Germany.
(author)
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Mäkinen, TaijaUppsala universitet,Vaskulärbiologi(Swepub:uu)taima352
(author)
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Detmar, MichaelSwiss Fed Inst Technol, Inst Pharmaceut Sci, Zurich, Switzerland.
(author)
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Moser, MarkusMax Planck Inst Biochem, Martinsried, Germany.;Tech Univ Munich, Inst Expt Hematol, Munich, Germany.
(author)
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Laemmermann, TimMax Planck Inst Immunobiol & Epigenet, Freiburg, Germany.
(author)
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Halin, CorneliaSwiss Fed Inst Technol, Inst Pharmaceut Sci, Zurich, Switzerland.
(author)
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Swiss Fed Inst Technol, Inst Pharmaceut Sci, Zurich, Switzerland.Max Planck Inst Immunobiol & Epigenet, Freiburg, Germany.;Univ Freiburg, Fac Biol, Freiburg, Germany.;Int Max Planck Res Sch Immunobiol Epigenet & Meta, Freiburg, Germany.
(creator_code:org_t)
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In:Journal of Experimental Medicine: Rockefeller University Press218:70022-10071540-9538
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Arasa, Jorge
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Collado-Diaz, Vi ...
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Kritikos, Ioanni ...
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Mäkinen, Taija
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