SwePub
Tyck till om SwePub Sök här!
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Zheng Ying)
 

Sökning: WFRF:(Zheng Ying) > Lysine demethylase ...

Lysine demethylase LSD1 delivered via small extracellular vesicles promotes gastric cancer cell stemness

Zhao, Li-Juan (författare)
Collaborat Innovat Ctr New Drug Res & Safety Eval, State Key Lab Esophageal Canc Prevent & Treatment, Key Lab Adv Drug Preparat Technol, Minist Educ China, Zhengzhou, Henan, Peoples R China.;Zhengzhou Univ, Acad Med Sci, Key Lab Henan Prov Drug Qual & Evaluat, Inst Drug Discovery & Dev,Sch Pharmaceut Sci, Zhengzhou, Peoples R China.
Li, Ying-Ying (författare)
Collaborat Innovat Ctr New Drug Res & Safety Eval, State Key Lab Esophageal Canc Prevent & Treatment, Key Lab Adv Drug Preparat Technol, Minist Educ China, Zhengzhou, Henan, Peoples R China.;Zhengzhou Univ, Acad Med Sci, Key Lab Henan Prov Drug Qual & Evaluat, Inst Drug Discovery & Dev,Sch Pharmaceut Sci, Zhengzhou, Peoples R China.
Zhang, Yu-Tong (författare)
Collaborat Innovat Ctr New Drug Res & Safety Eval, State Key Lab Esophageal Canc Prevent & Treatment, Key Lab Adv Drug Preparat Technol, Minist Educ China, Zhengzhou, Henan, Peoples R China.;Zhengzhou Univ, Acad Med Sci, Key Lab Henan Prov Drug Qual & Evaluat, Inst Drug Discovery & Dev,Sch Pharmaceut Sci, Zhengzhou, Peoples R China.
visa fler...
Fan, Qi-Qi (författare)
Collaborat Innovat Ctr New Drug Res & Safety Eval, State Key Lab Esophageal Canc Prevent & Treatment, Key Lab Adv Drug Preparat Technol, Minist Educ China, Zhengzhou, Henan, Peoples R China.;Zhengzhou Univ, Acad Med Sci, Key Lab Henan Prov Drug Qual & Evaluat, Inst Drug Discovery & Dev,Sch Pharmaceut Sci, Zhengzhou, Peoples R China.
Ren, Hong-Mei (författare)
Collaborat Innovat Ctr New Drug Res & Safety Eval, State Key Lab Esophageal Canc Prevent & Treatment, Key Lab Adv Drug Preparat Technol, Minist Educ China, Zhengzhou, Henan, Peoples R China.;Zhengzhou Univ, Acad Med Sci, Key Lab Henan Prov Drug Qual & Evaluat, Inst Drug Discovery & Dev,Sch Pharmaceut Sci, Zhengzhou, Peoples R China.
Zhang, Cheng (författare)
KTH,Science for Life Laboratory, SciLifeLab,Systembiologi
Mardinoglu, Adil (författare)
KTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Kings Coll London, Ctr Host Microbiome Interact, Fac Dent Oral & Craniofacial Sci, London, England.
Chen, Wen-Chao (författare)
Zhengzhou Univ, Henan Prov Peoples Hosp, Dept Gastrointestinal Surg, Zhengzhou, Peoples R China.
Pang, Jing-Ru (författare)
Collaborat Innovat Ctr New Drug Res & Safety Eval, State Key Lab Esophageal Canc Prevent & Treatment, Key Lab Adv Drug Preparat Technol, Minist Educ China, Zhengzhou, Henan, Peoples R China.;Zhengzhou Univ, Acad Med Sci, Key Lab Henan Prov Drug Qual & Evaluat, Inst Drug Discovery & Dev,Sch Pharmaceut Sci, Zhengzhou, Peoples R China.
Shen, Dan-Dan (författare)
Collaborat Innovat Ctr New Drug Res & Safety Eval, State Key Lab Esophageal Canc Prevent & Treatment, Key Lab Adv Drug Preparat Technol, Minist Educ China, Zhengzhou, Henan, Peoples R China.;Zhengzhou Univ, Acad Med Sci, Key Lab Henan Prov Drug Qual & Evaluat, Inst Drug Discovery & Dev,Sch Pharmaceut Sci, Zhengzhou, Peoples R China.
Wang, Jun-Wei (författare)
Collaborat Innovat Ctr New Drug Res & Safety Eval, State Key Lab Esophageal Canc Prevent & Treatment, Key Lab Adv Drug Preparat Technol, Minist Educ China, Zhengzhou, Henan, Peoples R China.;Zhengzhou Univ, Acad Med Sci, Key Lab Henan Prov Drug Qual & Evaluat, Inst Drug Discovery & Dev,Sch Pharmaceut Sci, Zhengzhou, Peoples R China.
Zhao, Long-Fei (författare)
Collaborat Innovat Ctr New Drug Res & Safety Eval, State Key Lab Esophageal Canc Prevent & Treatment, Key Lab Adv Drug Preparat Technol, Minist Educ China, Zhengzhou, Henan, Peoples R China.;Zhengzhou Univ, Acad Med Sci, Key Lab Henan Prov Drug Qual & Evaluat, Inst Drug Discovery & Dev,Sch Pharmaceut Sci, Zhengzhou, Peoples R China.
Zhang, Jian-Ying (författare)
Zhengzhou Univ, Henan Inst Med & Pharmaceut Sci, Zhengzhou, Peoples R China.
Wang, Zhen-Ya (författare)
Zhengzhou Univ, Inst Drug Discovery & Dev, Key Lab Runliang Antiviral Medicines Res & Dev, Zhengzhou, Peoples R China.
Zheng, Yi-Chao (författare)
Collaborat Innovat Ctr New Drug Res & Safety Eval, State Key Lab Esophageal Canc Prevent & Treatment, Key Lab Adv Drug Preparat Technol, Minist Educ China, Zhengzhou, Henan, Peoples R China.;Zhengzhou Univ, Acad Med Sci, Key Lab Henan Prov Drug Qual & Evaluat, Inst Drug Discovery & Dev,Sch Pharmaceut Sci, Zhengzhou, Peoples R China.
Liu, Hong-Min (författare)
Collaborat Innovat Ctr New Drug Res & Safety Eval, State Key Lab Esophageal Canc Prevent & Treatment, Key Lab Adv Drug Preparat Technol, Minist Educ China, Zhengzhou, Henan, Peoples R China.;Zhengzhou Univ, Acad Med Sci, Key Lab Henan Prov Drug Qual & Evaluat, Inst Drug Discovery & Dev,Sch Pharmaceut Sci, Zhengzhou, Peoples R China.
visa färre...
Collaborat Innovat Ctr New Drug Res & Safety Eval, State Key Lab Esophageal Canc Prevent & Treatment, Key Lab Adv Drug Preparat Technol, Minist Educ China, Zhengzhou, Henan, Peoples R China;Zhengzhou Univ, Acad Med Sci, Key Lab Henan Prov Drug Qual & Evaluat, Inst Drug Discovery & Dev,Sch Pharmaceut Sci, Zhengzhou, Peoples R China. Science for Life Laboratory, SciLifeLab (creator_code:org_t)
2021-05-31
2021
Engelska.
Ingår i: EMBO Reports. - : EMBO. - 1469-221X .- 1469-3178. ; 22:8
Relaterad länk:
https://urn.kb.se/re...
visa fler...
https://doi.org/10.1...
visa färre...
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Several studies have examined the functions of nucleic acids in small extracellular vesicles (sEVs). However, much less is known about the protein cargos of sEVs and their functions in recipient cells. This study demonstrates the presence of lysine-specific demethylase 1 (LSD1), which is the first identified histone demethylase, in the culture medium of gastric cancer cells. We show that sEVs derived from gastric cancer cells and the plasma of patients with gastric cancer harbor LSD1. The shuttling of LSD1-containing sEVs from donor cells to recipient gastric cancer cells promotes cancer cell stemness by positively regulating the expression of Nanog, OCT4, SOX2, and CD44. Additionally, sEV-delivered LSD1 suppresses oxaliplatin response of recipient cells in vitro and in vivo, whereas LSD1-depleted sEVs do not. Taken together, we demonstrate that LSD1-loaded sEVs can promote stemness and chemoresistance to oxaliplatin. These findings suggest that the LSD1 content of sEV could serve as a biomarker to predict oxaliplatin response in gastric cancer patients.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)

Nyckelord

gastric cancer
LSD1
small extracellular vesicles
stemness

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy