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Sökning: WFRF:(Koppelman Gerard H.) > (2020-2022) > A novel whole blood...

  • Lemonnier, NathanaëlUGA, INSERM U1209, CNRS, UMR5309,Inst Adv Biosci, Site Sante,Allee Alpes, F-38700 La Tronche, France. (författare)

A novel whole blood gene expression signature for asthma, dermatitis, and rhinitis multimorbidity in children and adolescents

  • Artikel/kapitelEngelska2020

Förlag, utgivningsår, omfång ...

  • 2020-04-23
  • WILEY,2020
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-450774
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-450774URI
  • https://doi.org/10.1111/all.14314DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:143511808URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background: Allergic diseases often occur in combination (multimorbidity). Human blood transcriptome studies have not addressed multimorbidity. Large-scale gene expression data were combined to retrieve biomarkers and signaling pathways to disentangle allergic multimorbidity phenotypes.Methods: Integrated transcriptomic analysis was conducted in 1233 participants with a discovery phase using gene expression data (Human Transcriptome Array 2.0) from whole blood of 786 children from three European birth cohorts (MeDALL), and a replication phase using RNA Sequencing data from an independent cohort (EVA-PR, n = 447). Allergic diseases (asthma, atopic dermatitis, rhinitis) were considered as single disease or multimorbidity (at least two diseases), and compared with no disease.Results: Fifty genes were differentially expressed in allergic diseases. Thirty-two were not previously described in allergy. Eight genes were consistently overexpressed in all types of multimorbidity for asthma, dermatitis, and rhinitis (CLC, EMR4P, IL5RA, FRRS1, HRH4, SLC29A1, SIGLEC8, IL1RL1). All genes were replicated the in EVA-PR cohort. RT-qPCR validated the overexpression of selected genes. In MeDALL, 27 genes were differentially expressed in rhinitis alone, but none was significant for asthma or dermatitis alone. The multimorbidity signature was enriched in eosinophil-associated immune response and signal transduction. Protein-protein interaction network analysis identified IL5/JAK/STAT and IL33/ST2/IRAK/TRAF as key signaling pathways in multimorbid diseases. Synergistic effect of multimorbidity on gene expression levels was found.Conclusion: A signature of eight genes identifies multimorbidity for asthma, rhinitis, and dermatitis. Our results have clinical and mechanistic implications, and suggest that multimorbidity should be considered differently than allergic diseases occurring alone.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Melen, ErikKarolinska Institutet (författare)
  • Jiang, YaleUniv Pittsburgh, UPMC Childrens Hosp Pittsburgh, Div Pediat Pulm Med, Pittsburgh, PA USA.;Tsinghua Univ, Sch Med, Beijing, Peoples R China. (författare)
  • Joly, StephaneINSERM, Int Ctr Infectiol Res, CIRI, Lyon, France. (författare)
  • Menard, CamilleINSERM, Int Ctr Infectiol Res, CIRI, Lyon, France. (författare)
  • Aguilar, DanielBiomed Res Networking Ctr Hepat & Digest Dis CIBE, Barcelona, Spain. (författare)
  • Acosta-Perez, EdnaUniv Puerto Rico, Behav Sci Res Inst, San Juan, PR 00936 USA. (författare)
  • Bergstrom, AnnaKarolinska Institutet (författare)
  • Boutaoui, NadiaUniv Pittsburgh, UPMC Childrens Hosp Pittsburgh, Div Pediat Pulm Med, Pittsburgh, PA USA. (författare)
  • Bustamante, MarionaBarcelona Inst Global Hlth, ISGlobal, Barcelona, Spain.;UPF, Barcelona, Spain.;Inst Salud Carlos III, Spanish Consortium Res Epidemiol & Publ Hlth CIBE, Madrid, Spain. (författare)
  • Canino, GlorisaUniv Puerto Rico, Behav Sci Res Inst, San Juan, PR 00936 USA. (författare)
  • Forno, ErickUniv Pittsburgh, UPMC Childrens Hosp Pittsburgh, Div Pediat Pulm Med, Pittsburgh, PA USA. (författare)
  • Ramon Gonzalez, JuanBarcelona Inst Global Hlth, ISGlobal, Barcelona, Spain. (författare)
  • Garcia-Aymerich, JudithBarcelona Inst Global Hlth, ISGlobal, Barcelona, Spain. (författare)
  • Gruzieva, OlenaKarolinska Institutet (författare)
  • Guerra, StefanoBarcelona Inst Global Hlth, ISGlobal, Barcelona, Spain.;Univ Arizona, Asthma & Airway Dis Res Ctr, Tucson, AZ USA. (författare)
  • Heinrich, JoachimHelmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol, Munich, Germany.;Univ Hosp Munich LMU, Inner City Clin, Inst & Outpatient Clin Occupat Social & Environm, Munich, Germany. (författare)
  • Kull, IngerKarolinska Institutet (författare)
  • Ibarluzea Maurolagoitia, JesusInst Salud Carlos III, Spanish Consortium Res Epidemiol & Publ Hlth CIBE, Madrid, Spain.;BIODONOSTIA, Inst Invest Sanitaria, Donostia San Sebastian, Spain. (författare)
  • Santa-Marina Rodriguez, LoretoInst Salud Carlos III, Spanish Consortium Res Epidemiol & Publ Hlth CIBE, Madrid, Spain. (författare)
  • Thiering, ElisabethHelmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol, Munich, Germany.;Ludwig Maximilians Univ Munchen, Dr von Hauner Childrens Hosp, Div Metab Dis & Nutr Med, Munich, Germany. (författare)
  • Wickman, MagnusUppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD) (författare)
  • Akdis, CezmiUniv Zurich, Swiss Inst Allergy & Asthma Res SIAF, Davos, Switzerland. (författare)
  • Akdis, MübeccelUniv Zurich, Swiss Inst Allergy & Asthma Res SIAF, Davos, Switzerland. (författare)
  • Chen, WeiUniv Pittsburgh, UPMC Childrens Hosp Pittsburgh, Div Pediat Pulm Med, Pittsburgh, PA USA.;Univ Pittsburgh, Dept Biostat, Pittsburgh, PA 15261 USA. (författare)
  • Keil, ThomasCharite Univ Med Berlin, Inst Social Med Epidemiol & Hlth Econ, Berlin, Germany.;Univ Wurzburg, Inst Clin Epidemiol & Biometry, Wurzburg, Germany.;Bavarian Hlth & Food Safety Author, Inst Hlth Resort Med & Hlth Promot, Bad Kissingen, Germany. (författare)
  • Koppelman, Gerard H.Univ Groningen, Univ Med Ctr Groningen, Beatrix Childrens Hosp, Dept Pediat Pulmonol & Pediat Allergol, Groningen, Netherlands.;Univ Groningen, Univ Med Ctr Groningen, GRIAC Res Inst, Groningen, Netherlands. (författare)
  • Siroux, ValerieUGA, INSERM U1209, CNRS, UMR5309,Inst Adv Biosci, Site Sante,Allee Alpes, F-38700 La Tronche, France. (författare)
  • Xu, Cheng-JianUniv Groningen, Univ Med Ctr Groningen, Beatrix Childrens Hosp, Dept Pediat Pulmonol & Pediat Allergol, Groningen, Netherlands.;Univ Groningen, Univ Med Ctr Groningen, GRIAC Res Inst, Groningen, Netherlands. (författare)
  • Hainaut, PierreUGA, INSERM U1209, CNRS, UMR5309,Inst Adv Biosci, Site Sante,Allee Alpes, F-38700 La Tronche, France. (författare)
  • Standl, MarieHelmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol, Munich, Germany. (författare)
  • Sunyer, JordiBarcelona Inst Global Hlth, ISGlobal, Barcelona, Spain. (författare)
  • Celedon, Juan C.Univ Pittsburgh, UPMC Childrens Hosp Pittsburgh, Div Pediat Pulm Med, Pittsburgh, PA USA. (författare)
  • Maria Anto, JosepBarcelona Inst Global Hlth, ISGlobal, Barcelona, Spain. (författare)
  • Bousquet, JeanFdn Partenariale FMC VIA LR, MACVIA France, Montpellier, France.;Univ Versailles St Quentin En Yvelines, UMR S 1168, Ageing & Chron Dis Epidemiol & Publ Hlth Approach, Montigny Le Bretonneux, France.;Euforea, Brussels, Belgium.;Charite, Comprehens Allergy Ctr, Dept Dermatol & Allergy, Berlin, Germany. (författare)
  • Karolinska InstitutetUGA, INSERM U1209, CNRS, UMR5309,Inst Adv Biosci, Site Sante,Allee Alpes, F-38700 La Tronche, France. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Allergy. European Journal of Allergy and Clinical Immunology: WILEY75:12, s. 3248-32600105-45381398-9995

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