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Sökning: id:"swepub:oai:DiVA.org:uu-451556" > Maternal health, in...

  • Kitahara, Cari M.NCI, Div Canc Epidemiol & Genet, Rockville, MD 20892 USA. (författare)

Maternal health, in-utero, and perinatal exposures and risk of thyroid cancer in offspring : a Nordic population-based nested case-control study

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • Elsevier,2021
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-451556
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-451556URI
  • https://doi.org/10.1016/S2213-8587(20)30399-5DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:147164160URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background Thyroid cancer tends to be diagnosed at a younger age (median age 51 years) compared with most other malignancies (such as breast cancer [62 years] or lung cancer [71 years]). The incidence of thyroid cancer is higher in women than men diagnosed from early adolescence. However, few in-utero and early life risk exposures associated with increased risk of thyroid cancer have been identified. Methods In this population-based nested case-control study we used registry data from four Nordic countries to assess thyroid cancer risk in offspring in relation to maternal medical history, pregnancy complications, and birth characteristics. Patient with thyroid cancer (cases) were individuals born and subsequently diagnosed with first primary thyroid cancer from 1973 to 2013 in Denmark, 1987 to 2014 in Finland, 1967 to 2015 in Norway, or 1973 to 2014 in Sweden. Each case was matched with up to ten individuals without thyroid cancer (controls) based on birth year, sex, country, and county of birth. Cases and matched controls with a previous diagnosis of any cancer, other than non-melanoma skin cancer, at the time of thyroid cancer diagnosis were excluded. Cases and matched controls had to reside in the country of birth at the time of thyroid cancer diagnosis. Conditional logistic regression models were used to calculate odds ratios (ORs) with 95% CIs. Findings Of the 2437 cases, 1967 (81.4%) had papillary carcinomas, 1880 (77.1%) were women, and 1384 (56.7%) were diagnosed before age 30 years (range 0-48). Higher birth weight (OR per kg 1.14 [95% CI 1.05-1.23]) and congenital hypothyroidism (4.55 [1.58-13.08]); maternal diabetes before pregnancy (OR 1.69 [0.98-2.93]) and postpartum haemorrhage (OR 1.28 [1.06-1.55]); and (from registry data in Denmark) maternal hypothyroidism (18.12 [10.52-31.20]), hyperthyroidism (11.91 [6.77-20.94]), goiter (67.36 [39.89-113.76]), and benign thyroid neoplasms (22.50 [6.93-73.06]) were each associated with an increased risk of thyroid cancer in offspring. Interpretation In-utero exposures, particularly those related to maternal thyroid disorders, might have a long-term influence on thyroid cancer risk in offspring. 

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Daltveit, Dagrun SletteboUniv Bergen, Dept Global Publ Hlth & Primary Care, Bergen, Norway. (författare)
  • Ekbom, AndersKarolinska Institutet (författare)
  • Engeland, AndersUniv Bergen, Dept Global Publ Hlth & Primary Care, Bergen, Norway.;Norwegian Inst Publ Hlth, Div Mental & Phys Hlth, Bergen, Norway. (författare)
  • Gissler, MikaKarolinska Institutet (författare)
  • Glimelius, Ingrid,1975-Karolinska Institutet,Uppsala universitet,Experimentell och klinisk onkologi,Karolinska Inst, Div Clin Epidemiol, Dept Med, Stockholm, Sweden.;Karolinska Univ Hosp, Stockholm, Sweden.(Swepub:uu)inggl846 (författare)
  • Grotmol, TomCanc Registry Norway, Oslo, Norway. (författare)
  • Lagerros, Ylva TrolleKarolinska Institutet (författare)
  • Madanat-Harjuoja, LauraFinnish Canc Registry, Canc Soc Finland, Helsinki, Finland.;Univ Helsinki, Dept Pediat, Helsinki, Finland.;Helsinki Univ Hosp, Helsinki, Finland. (författare)
  • Mannisto, TuijaFinland Lab Ctr, Nordlab, Oulu, Finland. (författare)
  • Sorensen, Henrik ToftAarhus Univ Hosp, Dept Clin Epidemiol, Aarhus, Denmark. (författare)
  • Troisi, RebeccaNCI, Div Canc Epidemiol & Genet, Rockville, MD 20892 USA. (författare)
  • Bjorge, ToneUniv Bergen, Dept Global Publ Hlth & Primary Care, Bergen, Norway.;Canc Registry Norway, Oslo, Norway. (författare)
  • NCI, Div Canc Epidemiol & Genet, Rockville, MD 20892 USA.Univ Bergen, Dept Global Publ Hlth & Primary Care, Bergen, Norway. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:The Lancet Diabetes and Endocrinology: Elsevier9:2, s. 94-1052213-85872213-8595

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