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A multi-ethnic epig...
A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids
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- Jhun, Mina-A (författare)
- Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA.;Stanford Univ, Sch Med, Dept Med, Stanford, CA 94305 USA.
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- Mendelson, Michael (författare)
- NHLBI, Populat Sci Branch, NIH, Bldg 10, Bethesda, MD 20892 USA.;Boston Childrens Hosp, Dept Cardiol, Boston, MA USA.
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- Wilson, Rory (författare)
- German Res Ctr Environm Hlth, Inst Epidemiol, Res Unit Mol Epidemiol, Helmholtz Zentrum Munchen, Munich, Germany.;German Res Ctr Environm Hlth, Inst Epidemiol, Helmholtz Zentrum Munchen, Munich, Germany.
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visa fler...
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- Gondalia, Rahul (författare)
- Univ N Carolina, Dept Epidemiol, Chapel Hill, NC 27515 USA.
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- Joehanes, Roby (författare)
- Harvard Med Sch, Beth Israel Deaconess Med Ctr, Hebrew SeniorLife, Boston, MA 02115 USA.
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- Salfati, Elias (författare)
- Stanford Univ, Sch Med, Dept Med, Stanford, CA 94305 USA.
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- Zhao, Xiaoping (författare)
- Univ Texas Hlth Sci Ctr Houston, Inst Mol Med, Brown Fdn, McGovern Med Sch, Houston, TX 77030 USA.
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- Braun, Kim Valeska Emilie (författare)
- Erasmus MC, Univ Med Ctr, Dept Epidemiol, Rotterdam, Netherlands.
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- Do, Anh Nguyet (författare)
- Univ Alabama Birmingham, Sch Publ Hlth, Dept Epidemiol, Birmingham, AL 35294 USA.
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- Hedman, Åsa K (författare)
- Karolinska Institutet,Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
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- Zhang, Tao (författare)
- Tulane Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, New Orleans, LA USA.
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- Carnero-Montoro, Elena (författare)
- Kings Coll London, Sch Life Course Sci, Dept Twin Res & Genet Epidemiol, London, England.;Univ Granada, Ctr Genom & Oncol Res Pfizer, GENYO, Andalusian Reg Govt, Granada, Spain.
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- Shen, Jincheng (författare)
- Univ Utah, Dept Populat Hlth Sci, Salt Lake City, UT USA.
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- Bartz, Traci M. (författare)
- Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA.;Univ Washington, Dept Biostat, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA.
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- Brody, Jennifer A. (författare)
- Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA.
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- Montasser, May E. (författare)
- Univ Maryland, Sch Med, Div Endocrinol Diabet & Nutr, Baltimore, MD 21201 USA.;Univ Maryland, Sch Med, Program Personalized & Genom Med, Baltimore, MD 21201 USA.
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- O'Connell, Jeff R. (författare)
- Univ Maryland, Sch Med, Div Endocrinol Diabet & Nutr, Baltimore, MD 21201 USA.;Univ Maryland, Sch Med, Program Personalized & Genom Med, Baltimore, MD 21201 USA.
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- Yao, Chen (författare)
- NHLBI, Populat Sci Branch, NIH, Bldg 10, Bethesda, MD 20892 USA.
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- Xia, Rui (författare)
- Univ Texas Hlth Sci Ctr Houston, Inst Mol Med, Brown Fdn, McGovern Med Sch, Houston, TX 77030 USA.
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- Boerwinkle, Eric (författare)
- Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Houston, TX USA.
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- Grove, Megan (författare)
- Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Houston, TX USA.
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- Guan, Weihua (författare)
- Univ Minnesota, Sch Publ Hlth, Div Biostat, Minneapolis, MN USA.
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- Liliane, Pfeiffer (författare)
- German Res Ctr Environm Hlth, Inst Epidemiol, Res Unit Mol Epidemiol, Helmholtz Zentrum Munchen, Munich, Germany.;German Res Ctr Environm Hlth, Inst Epidemiol, Helmholtz Zentrum Munchen, Munich, Germany.
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- Singmann, Paula (författare)
- German Res Ctr Environm Hlth, Inst Epidemiol, Res Unit Mol Epidemiol, Helmholtz Zentrum Munchen, Munich, Germany.;German Res Ctr Environm Hlth, Inst Epidemiol, Helmholtz Zentrum Munchen, Munich, Germany.
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- Mueller-Nurasyid, Martina (författare)
- German Res Ctr Environm Hlth, Inst Genet Epidemiol, Helmholtz Zentrum Munchen, Neuherberg, Germany.;Ludwig Maximilians Univ Munchen, IBE, Fac Med, Munich, Germany.;Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Med Biostat Epidemiol & Informat IMBEI, Mainz, Germany.
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- Meitinger, Thomas (författare)
- Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Med Biostat Epidemiol & Informat IMBEI, Mainz, Germany.;German Res Ctr Environm Hlth, Inst Human Genet, Helmholtz Zentrum Munchen, Munich, Germany. Tech Univ Munich, Inst Human Genet, Munich, Germany.
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- Gieger, Christian (författare)
- German Res Ctr Environm Hlth, Inst Epidemiol, Res Unit Mol Epidemiol, Helmholtz Zentrum Munchen, Munich, Germany.;German Res Ctr Environm Hlth, Inst Epidemiol, Helmholtz Zentrum Munchen, Munich, Germany.
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- Peters, Annette (författare)
- German Res Ctr Environm Hlth, Inst Epidemiol, Helmholtz Zentrum Munchen, Munich, Germany.;Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Med Biostat Epidemiol & Informat IMBEI, Mainz, Germany.
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- Zhao, Wei (författare)
- Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA.
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- Ware, Erin B. (författare)
- Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA.;Survey Res Ctr, Inst Social Res, Ann Arbor, MI USA.
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- Smith, Jennifer A. (författare)
- Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA.;Survey Res Ctr, Inst Social Res, Ann Arbor, MI USA.
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- Dhana, Klodian (författare)
- Rush Univ, Med Ctr, Dept Internal Med, Chicago, IL 60612 USA.
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- van Meurs, Joyce (författare)
- Erasmus MC, Univ Med Ctr, Dept Internal Med, Rotterdam, Netherlands.
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- Uitterlinden, Andre (författare)
- Erasmus MC, Univ Med Ctr, Dept Internal Med, Rotterdam, Netherlands.
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- Ikram, Mohammad Arfan (författare)
- Erasmus MC, Univ Med Ctr, Dept Epidemiol, Rotterdam, Netherlands.
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- Ghanbari, Mohsen (författare)
- Erasmus MC, Univ Med Ctr, Dept Epidemiol, Rotterdam, Netherlands.
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- Zhi, Deugi (författare)
- Univ Texas Hlth Sci Ctr Houston, Sch Biomed Informat, Houston, TX 77030 USA.
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- Gustafsson, Stefan (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi
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- Lind, Lars (författare)
- Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
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- Li, Shengxu (författare)
- Tulane Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, New Orleans, LA USA.
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- Sun, Dianjianyi (författare)
- Tulane Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, New Orleans, LA USA.;Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing, Peoples R China.
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- Spector, Tim D. (författare)
- Kings Coll London, Sch Life Course Sci, Dept Twin Res & Genet Epidemiol, London, England.
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- Chen, Yii-der Ida (författare)
- Harbor UCLA Med Ctr, Los Angeles Biomed Res Inst, Inst Translat Genom & Populat Sci, Torrance, CA 90509 USA.;Harbor UCLA Med Ctr, Dept Pediat, Torrance, CA 90509 USA.
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- Damcott, Coleen (författare)
- Univ Maryland, Sch Med, Div Endocrinol Diabet & Nutr, Baltimore, MD 21201 USA.;Univ Maryland, Sch Med, Program Personalized & Genom Med, Baltimore, MD 21201 USA.
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- Shuldiner, Alan R. (författare)
- Univ Maryland, Sch Med, Div Endocrinol Diabet & Nutr, Baltimore, MD 21201 USA.;Univ Maryland, Sch Med, Program Personalized & Genom Med, Baltimore, MD 21201 USA.
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- Absher, Devin M. (författare)
- HudsonAlpha Inst Biotechnol, Huntsville, AL USA.
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- Horvath, Steve (författare)
- Univ Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA.;Univ Calif Los Angeles, Dept Biostat, Fielding Sch Publ Hlth, Los Angeles, CA USA.
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- Tsao, Philip S. (författare)
- Stanford Univ, Sch Med, Dept Med, Stanford, CA 94305 USA.;VA Palo Alto Healthcare Syst, Palo Alto, CA 94304 USA.;Stanford Univ, Stanford Cardiovasc Inst, Stanford, CA 94305 USA.
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- Kardia, Sharon (författare)
- Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA.
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- Psaty, Bruce M. (författare)
- Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA.;Univ Washington, Dept Epidemiol, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA.;Univ Washington, Dept Hlth Serv, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA.;Kaiser Permanente Washington Hlth Res Inst, Seattle, WA USA.
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- Sotoodehnia, Nona (författare)
- Univ Washington, Div Cardiol, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA.
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- Bell, Jordana T. (författare)
- Kings Coll London, Sch Life Course Sci, Dept Twin Res & Genet Epidemiol, London, England.
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- Ingelsson, Erik, 1975- (författare)
- Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Stanford Univ, Sch Med, Dept Med, Stanford, CA 94305 USA.;UppStanford Univ, Stanford Cardiovasc Inst, Stanford, CA 94305 USA.;Stanford Univ, Stanford Diabet Res Ctr, Stanford, CA 94305 USA.
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- Chen, Wei (författare)
- Tulane Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, New Orleans, LA USA.
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- Dehghan, Abbas (författare)
- Erasmus MC, Univ Med Ctr, Dept Epidemiol, Rotterdam, Netherlands.;Imperial Coll, Sch Publ Hlth, MRC Ctr Environm & Hlth, Dept Biostat & Epidemiol, London, England.
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- Arnett, Donna K. (författare)
- Univ Alabama Birmingham, Sch Publ Hlth, Dept Epidemiol, Birmingham, AL 35294 USA.
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- Waldenberger, Melanie (författare)
- German Res Ctr Environm Hlth, Inst Epidemiol, Res Unit Mol Epidemiol, Helmholtz Zentrum Munchen, Munich, Germany.;German Res Ctr Environm Hlth, Inst Epidemiol, Helmholtz Zentrum Munchen, Munich, Germany.
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- Hou, Lifang (författare)
- Northwestern Univ, Dept Prevent Med, Feinberg Sch Med, Chicago, IL 60611 USA.
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- Whitsel, Eric A. (författare)
- Univ N Carolina, Dept Epidemiol, Chapel Hill, NC 27515 USA.;Univ N Carolina, Dept Med, Chapel Hill, NC 27515 USA.
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- Baccarelli, Andrea (författare)
- Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth Sci, Boston, MA USA.;Columbia Univ, Dept Environm Hlth Sci, Mailman Sch Publ Hlth, New York, NY USA.
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- Levy, Daniel (författare)
- NHLBI, Populat Sci Branch, NIH, Bldg 10, Bethesda, MD 20892 USA.;Framingham Heart Dis Epidemiol Study, Framingham, MA USA.
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- Fornage, Myriam (författare)
- Univ Texas Hlth Sci Ctr Houston, Inst Mol Med, Brown Fdn, McGovern Med Sch, Houston, TX 77030 USA.
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- Irvin, Marguerite R. (författare)
- Univ Alabama Birmingham, Sch Publ Hlth, Dept Epidemiol, Birmingham, AL 35294 USA.
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- Assimes, Themistocles L. (författare)
- Stanford Univ, Sch Med, Dept Med, Stanford, CA 94305 USA.;VA Palo Alto Healthcare Syst, Palo Alto, CA 94304 USA.;Stanford Univ, Stanford Cardiovasc Inst, Stanford, CA 94305 USA.
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Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA;Stanford Univ, Sch Med, Dept Med, Stanford, CA 94305 USA. NHLBI, Populat Sci Branch, NIH, Bldg 10, Bethesda, MD 20892 USA.;Boston Childrens Hosp, Dept Cardiol, Boston, MA USA. (creator_code:org_t)
- 2021-06-28
- 2021
- Engelska.
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Ingår i: Nature Communications. - : Springer Nature. - 2041-1723. ; 12:1
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Here we examine the association between DNA methylation in circulating leukocytes and blood lipids in a multi-ethnic sample of 16,265 subjects. We identify 148, 35, and 4 novel associations among Europeans, African Americans, and Hispanics, respectively, and an additional 186 novel associations through a trans-ethnic meta-analysis. We observe a high concordance in the direction of effects across racial/ethnic groups, a high correlation of effect sizes between high-density lipoprotein and triglycerides, a modest overlap of associations with epigenome-wide association studies of other cardio-metabolic traits, and a largely non-overlap with lipid loci identified to date through genome-wide association studies. Thirty CpGs reached significance in at least 2 racial/ethnic groups including 7 that showed association with the expression of an annotated gene. CpGs annotated to CPT1A showed evidence of being influenced by triglycerides levels. DNA methylation levels of circulating leukocytes show robust and consistent association with blood lipid levels across multiple racial/ethnic groups. Abnormal blood lipid levels are important risk factors for cardiovascular and other various diseases. Here the authors conduct a large-scale multi-ethnic epigenome-wide association study combined with epigenetic (cis-QTL and eQTM) data, and identify CpG-lipid traits associations that are specific to or common across racial/ethnic groups.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
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- Av författaren/redakt...
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Jhun, Mina-A
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Mendelson, Micha ...
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Wilson, Rory
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Gondalia, Rahul
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Joehanes, Roby
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Salfati, Elias
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visa fler...
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Zhao, Xiaoping
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Braun, Kim Vales ...
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Do, Anh Nguyet
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Hedman, Åsa K
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Zhang, Tao
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Carnero-Montoro, ...
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Shen, Jincheng
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Bartz, Traci M.
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Brody, Jennifer ...
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Montasser, May E ...
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O'Connell, Jeff ...
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Yao, Chen
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Xia, Rui
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Boerwinkle, Eric
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Grove, Megan
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Guan, Weihua
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Liliane, Pfeiffe ...
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Singmann, Paula
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Mueller-Nurasyid ...
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Meitinger, Thoma ...
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Gieger, Christia ...
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Peters, Annette
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Zhao, Wei
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Ware, Erin B.
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Smith, Jennifer ...
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Dhana, Klodian
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van Meurs, Joyce
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Uitterlinden, An ...
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Ikram, Mohammad ...
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Ghanbari, Mohsen
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Zhi, Deugi
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Gustafsson, Stef ...
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Lind, Lars
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Li, Shengxu
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Sun, Dianjianyi
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Spector, Tim D.
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Chen, Yii-der Id ...
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Damcott, Coleen
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Shuldiner, Alan ...
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Absher, Devin M.
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Horvath, Steve
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Tsao, Philip S.
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Kardia, Sharon
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Psaty, Bruce M.
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Sotoodehnia, Non ...
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Bell, Jordana T.
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Ingelsson, Erik, ...
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Chen, Wei
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Dehghan, Abbas
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Arnett, Donna K.
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Waldenberger, Me ...
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Hou, Lifang
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Whitsel, Eric A.
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Baccarelli, Andr ...
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Levy, Daniel
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Fornage, Myriam
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Irvin, Marguerit ...
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Assimes, Themist ...
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MEDICIN OCH HÄLS ...
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