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Key molecular alter...
Key molecular alterations in endothelial cells in human glioblastoma uncovered through single-cell RNA sequencing
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- Xie, Yuan (author)
- Shaanxi Normal Univ, Coll Life Sci, China Sweden Int Joint Res Ctr Brain Dis,Natl Eng, Key Lab,Minist Educ Med Plant Resource & Nat Phar, Xian, Peoples R China.
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- He, Liqun (author)
- Uppsala universitet,Vaskulärbiologi,Science for Life Laboratory, SciLifeLab,Tianjin Med Univ, Dept Neurosurg, Gen Hosp,Minist Educ, Tianjin Neurol Inst,Key Lab Postneuro Injury Neur, Tianjin, Peoples R China.
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- Lugano, Roberta (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Vaskulärbiologi
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- Zhang, Yanyu (author)
- Shaanxi Normal Univ, Coll Life Sci, China Sweden Int Joint Res Ctr Brain Dis,Natl Eng, Key Lab,Minist Educ Med Plant Resource & Nat Phar, Xian, Peoples R China.
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- Cao, Haiyan (author)
- Fourth Mil Med Univ, Dept Neurosurg, Tangdu Hosp, 569 Xinsi Rd, Xian 710038, Peoples R China.
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- He, Qiyuan (author)
- Shaanxi Normal Univ, Coll Life Sci, China Sweden Int Joint Res Ctr Brain Dis,Natl Eng, Key Lab,Minist Educ Med Plant Resource & Nat Phar, Xian, Peoples R China.
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- Chao, Min (author)
- Fourth Mil Med Univ, Dept Neurosurg, Tangdu Hosp, 569 Xinsi Rd, Xian 710038, Peoples R China.
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- Liu, Boxuan (author)
- Second Peoples Hosp Huaihua, Precis Med Ctr, Huaihua, Peoples R China.
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- Cao, Qingze (author)
- Shaanxi Normal Univ, Coll Life Sci, China Sweden Int Joint Res Ctr Brain Dis,Natl Eng, Key Lab,Minist Educ Med Plant Resource & Nat Phar, Xian, Peoples R China.
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- Wang, Jianhao (author)
- Tianjin Med Univ, Dept Neurosurg, Gen Hosp,Minist Educ, Tianjin Neurol Inst,Key Lab Postneuro Injury Neur, Tianjin, Peoples R China.
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- Jiao, Yang (author)
- Fourth Mil Med Univ, Dept Neurosurg, Tangdu Hosp, 569 Xinsi Rd, Xian 710038, Peoples R China.
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- Hu, Yaqin (author)
- Fourth Mil Med Univ, Dept Neurosurg, Tangdu Hosp, 569 Xinsi Rd, Xian 710038, Peoples R China.
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- Han, Liying (author)
- Fourth Mil Med Univ, Dept Neurosurg, Tangdu Hosp, 569 Xinsi Rd, Xian 710038, Peoples R China.
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- Zhang, Yong (author)
- Genergy Biotechnol Shanghai Co Ltd, Shanghai, Peoples R China.
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- Huang, Hua, 1986- (author)
- Uppsala universitet,Vaskulärbiologi,Science for Life Laboratory, SciLifeLab
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- Uhrbom, Lene (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Neuroonkologi
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- Betsholtz, Christer (author)
- Uppsala universitet,Vaskulärbiologi,Science for Life Laboratory, SciLifeLab,Karolinska Inst, Dept Med Huddinge MedH, Huddinge, Sweden.
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- Wang, Liang (author)
- Fourth Mil Med Univ, Dept Neurosurg, Tangdu Hosp, 569 Xinsi Rd, Xian 710038, Peoples R China.
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- Dimberg, Anna (author)
- Uppsala universitet,Vaskulärbiologi,Science for Life Laboratory, SciLifeLab
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- Zhang, Lei (author)
- Shaanxi Normal Univ, Coll Life Sci, China Sweden Int Joint Res Ctr Brain Dis,Natl Eng, Key Lab,Minist Educ Med Plant Resource & Nat Phar, Xian, Peoples R China.;Second Peoples Hosp Huaihua, Precis Med Ctr, Huaihua, Peoples R China.
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Shaanxi Normal Univ, Coll Life Sci, China Sweden Int Joint Res Ctr Brain Dis,Natl Eng, Key Lab,Minist Educ Med Plant Resource & Nat Phar, Xian, Peoples R China Vaskulärbiologi (creator_code:org_t)
- 2021-07-06
- 2021
- English.
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In: JCI Insight. - : American Society For Clinical Investigation. - 2379-3708. ; 6:15
- Related links:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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http://insight.jci.o...
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Abstract
Subject headings
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- Passage of systemically delivered pharmacological agents into the brain is largely blocked by the blood-brain-barrier (BBB), an organotypic specialization of brain endothelial cells (ECs). Tumor vessels in glioblastoma (GBM), the most common malignant brain tumor in humans, are abnormally permeable, but this phenotype is heterogeneous and may differ between the tumor's center and invasive front. Here, through single-cell RNA sequencing (scRNA-seq) of freshly isolated ECs from human glioblastoma and paired tumor peripheral tissues, we have constructed a molecular atlas of human brain ECs providing unprecedented molecular insight into the heterogeneity of the human BBB and its molecular alteration in glioblastoma. We identified 5 distinct EC phenotypes representing different states of EC activation and BBB impairment, and associated with different anatomical locations within and around the tumor. This unique data resource provides key information for designing rational therapeutic regimens and optimizing drug delivery.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Xie, Yuan
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He, Liqun
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Lugano, Roberta
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Zhang, Yanyu
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Cao, Haiyan
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He, Qiyuan
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show more...
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Chao, Min
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Liu, Boxuan
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Cao, Qingze
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Wang, Jianhao
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Jiao, Yang
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Hu, Yaqin
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Han, Liying
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Zhang, Yong
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Huang, Hua, 1986 ...
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Uhrbom, Lene
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Betsholtz, Chris ...
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Wang, Liang
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Dimberg, Anna
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Zhang, Lei
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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JCI Insight
- By the university
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Uppsala University
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Karolinska Institutet