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Mapping chromatin accessibility and active regulatory elements reveals pathological mechanisms in human gliomas

Stepniak, Karolina (author)
Polish Acad Sci, Nencki Inst Expt Biol, Warsaw, Poland.;Med Univ Gdansk, Int Res Agenda 3P Med Lab, Gdansk, Poland.
Machnicka, Magdalena A. (author)
Univ Warsaw, Fac Math Informat & Mech, Warsaw, Poland.;Med Univ Gdansk, Int Res Agenda 3P Med Lab, Gdansk, Poland.
Mieczkowski, Jakub (author)
Polish Acad Sci, Nencki Inst Expt Biol, Warsaw, Poland.;Med Univ Gdansk, Int Res Agenda 3P Med Lab, Gdansk, Poland.
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Macioszek, Anna (author)
Univ Warsaw, Fac Math Informat & Mech, Warsaw, Poland.
Wojtas, Bartosz (author)
Polish Acad Sci, Nencki Inst Expt Biol, Warsaw, Poland.
Gielniewski, Bartlomiej (author)
Polish Acad Sci, Nencki Inst Expt Biol, Warsaw, Poland.
Poleszak, Katarzyna (author)
Polish Acad Sci, Nencki Inst Expt Biol, Warsaw, Poland.
Perycz, Malgorzata (author)
Polish Acad Sci, Nencki Inst Expt Biol, Warsaw, Poland.
Król, Sylwia K. (author)
Polish Acad Sci, Nencki Inst Expt Biol, Warsaw, Poland.
Guzik, Rafal (author)
Polish Acad Sci, Nencki Inst Expt Biol, Warsaw, Poland.
Dabrowski, Michal J. (author)
Draminski, Michal (author)
Polish Acad Sci, Inst Comp Sci, Warsaw, Poland.
Jardanowska, Marta (author)
Polish Acad Sci, Inst Comp Sci, Warsaw, Poland.
Grabowicz, Ilona (author)
Polish Acad Sci, Inst Comp Sci, Warsaw, Poland.
Dziedzic, Agata (author)
Polish Acad Sci, Inst Comp Sci, Warsaw, Poland.
Kranas, Hanna (author)
Univ Warsaw, Fac Math Informat & Mech, Warsaw, Poland
Sienkiewicz, Karolina (author)
Univ Warsaw, Fac Math Informat & Mech, Warsaw, Poland.
Diamanti, Klev, 1987- (author)
Uppsala universitet,Medicinsk genetik och genomik
Kotulska, Katarzyna (author)
Childrens Mem Hlth Inst, Dept Neurol, Warsaw, Poland.;Childrens Mem Hlth Inst, Dept Neurosurg, Warsaw, Poland.;Childrens Mem Hlth Inst, Dept Neuropathol, Warsaw, Poland.
Grajkowska, Wieslawa (author)
Childrens Mem Hlth Inst, Dept Neurol, Warsaw, Poland.;Childrens Mem Hlth Inst, Dept Neurosurg, Warsaw, Poland.;Childrens Mem Hlth Inst, Dept Neuropathol, Warsaw, Poland.
Roszkowski, Marcin (author)
Childrens Mem Hlth Inst, Dept Neurol, Warsaw, Poland.;Childrens Mem Hlth Inst, Dept Neurosurg, Warsaw, Poland.;Childrens Mem Hlth Inst, Dept Neuropathol, Warsaw, Poland.
Czernicki, Tomasz (author)
Med Univ Warsaw, Dept Neurosurg, Warsaw, Poland.
Marchel, Andrzej (author)
Med Univ Warsaw, Dept Neurosurg, Warsaw, Poland.
Komorowski, Jan (author)
Uppsala universitet,Beräkningsbiologi och bioinformatik
Kaminska, Bozena (author)
Polish Acad Sci, Nencki Inst Expt Biol, Warsaw, Poland.
Wilczynski, Bartek (author)
Univ Warsaw, Fac Math Informat & Mech, Warsaw, Poland.
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Polish Acad Sci, Nencki Inst Expt Biol, Warsaw, Poland;Med Univ Gdansk, Int Res Agenda 3P Med Lab, Gdansk, Poland. Univ Warsaw, Fac Math Informat & Mech, Warsaw, Poland.;Med Univ Gdansk, Int Res Agenda 3P Med Lab, Gdansk, Poland. (creator_code:org_t)
2021-06-15
2021
English.
In: Nature Communications. - : Springer Nature. - 2041-1723. ; 12:1
Related links:
https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Chromatin structure and accessibility, and combinatorial binding of transcription factors to regulatory elements in genomic DNA control transcription. Genetic variations in genes encoding histones, epigenetics-related enzymes or modifiers affect chromatin structure/dynamics and result in alterations in gene expression contributing to cancer development or progression. Gliomas are brain tumors frequently associated with epigenetics-related gene deregulation. We perform whole-genome mapping of chromatin accessibility, histone modifications, DNA methylation patterns and transcriptome analysis simultaneously in multiple tumor samples to unravel epigenetic dysfunctions driving gliomagenesis. Based on the results of the integrative analysis of the acquired profiles, we create an atlas of active enhancers and promoters in benign and malignant gliomas. We explore these elements and intersect with Hi-C data to uncover molecular mechanisms instructing gene expression in gliomas. Gliomas are tumors often associated with epigenetics-related gene deregulation. Here the authors reveal an atlas of active enhancers and promoters in benign and malignant gliomas by performing whole-genome mapping of chromatin accessibility, histone modifications, DNA methylation patterns and transcriptome analysis simultaneously in multiple tumor samples.

Subject headings

NATURVETENSKAP  -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
NATURVETENSKAP  -- Biologi -- Genetik (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Genetics (hsv//eng)

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