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Sökning: WFRF:(Wrigge Hermann) > (2020-2022) > Outcome of acute hy...

Outcome of acute hypoxaemic respiratory failure : insights from the LUNG SAFE Study

Pham, Tai (författare)
Unity Heath Toronto, Li Ka Shing Knowledge Inst, Keenan Res Ctr, St Michaels Hosp, Toronto, ON, Canada.;Univ Toronto, Interdept Div Crit Care Med, Toronto, ON, Canada.;Univ Paris Saclay, Serv Med Intens Reanimat, Grp Rech Clin CARMAS, Hop Bicetre,AP HP,FHU SEPSIS,DMU CORREVE, Le Kremlin Bicetre, France.;Univ Paris Saclay, Univ Paris Sud, CESP, Equipe Epidemiol Resp Integrat,UVSQ,Inserm, Villejuif, France.
Pesenti, Antonio (författare)
Osped Maggiore Policlin, Fdn IRCCS Ca Granda, Dipartimento Anestesia Rianimaz Emergenza Urgenza, Milan, Italy.;Univ Milan, Dipartimento Fisiopatol Med Chirurg & Trapianti, Milan, Italy.
Bellani, Giacomo (författare)
Univ Milano Bicocca, Sch Med & Surg, Monza, Italy.;San Gerardo Hosp, Dept Emergency & Intens Care, Monza, Italy.
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Rubenfeld, Gordon (författare)
Univ Toronto, Interdept Div Crit Care Med, Toronto, ON, Canada.;Sunnybrook Hlth Sci Ctr, Program Trauma Emergency & Crit Care, Toronto, ON, Canada.
Fan, Eddy (författare)
Univ Toronto, Interdept Div Crit Care Med, Toronto, ON, Canada.;Univ Hlth Network, Dept Med, Toronto, ON, Canada.;Mt Sinai Hosp, Toronto, ON, Canada.;Univ Toronto, Inst Hlth Policy Management & Evaluat, Toronto, ON, Canada.
Bugedo, Guillermo (författare)
Pontificia Univ Catolica Chile, Fac Med, Dept Med Intens, Santiago, Chile.
Lorente, Jose Angel (författare)
Hosp Univ Getafe, Crit Care Dept, Madrid, Spain.;CIBER Enfermedades Resp, Madrid, Spain.;Univ Europea, Madrid, Spain.
Fernandes, Antero do Vale (författare)
Hosp Garcia de Orta, Serv Med Intens, EPE, Almada, Portugal.
Van Haren, Frank (författare)
Canberra Hosp, Intens Care Unit, Garran, Australia.;Australian Natl Univ, Canberra Hosp, Med Sch, Garran, Australia.;Univ Canberra, Fac Hlth, Canberra, ACT, Australia.
Bruhn, Alejandro (författare)
Pontificia Univ Catolica Chile, Fac Med, Dept Med Intens, Santiago, Chile.
Rios, Fernando (författare)
Hosp Nacl Alejandro Posadas, Intens Care Unit, Buenos Aires, DF, Argentina.
Esteban, Andres (författare)
Hosp Univ Getafe, Ctr Invest Red Enfermedades Resp CIBERES, Madrid, Spain.
Gattinoni, Luciano (författare)
Univ Gottingen, Dept Anaesthesiol Emergency & Intens Care Med, Gottingen, Germany.
Larsson, Anders (författare)
Uppsala universitet,Institutionen för medicinska vetenskaper
McAuley, Daniel F. (författare)
Queens Univ Belfast, Ctr Expt Med, Belfast, Antrim, North Ireland.;Royal Victoria Hosp, Reg Intens Care Unit, Belfast, Antrim, North Ireland.
Ranieri, Marco (författare)
Univ Bologna, Policlin St Orsola, Alma Mater Studiorum, Dipartimento Sci Med & Chirurg,Anesthesia & Inten, Bologna, Italy.
Thompson, B. Taylor (författare)
Harvard Sch Med, Massachusetts Gen Hosp, Dept Med, Div Pulm & Crit Care Med, Boston, MA USA.
Wrigge, Hermann (författare)
Univ Hosp Leipzig, Dept Anesthesiol & Intens Care Med, Leipzig, Germany.;Bergmannstrost Hosp Halle, Dept Anesthesiol Intens Care & Emergency Med, Pain Therapy, Halle, Germany.
Brochard, Laurent J. (författare)
Unity Heath Toronto, Li Ka Shing Knowledge Inst, Keenan Res Ctr, St Michaels Hosp, Toronto, ON, Canada.;Univ Toronto, Interdept Div Crit Care Med, Toronto, ON, Canada.
Laffey, John G. (författare)
Unity Heath Toronto, Li Ka Shing Knowledge Inst, Keenan Res Ctr, St Michaels Hosp, Toronto, ON, Canada.;Univ Toronto, Interdept Div Crit Care Med, Toronto, ON, Canada.;St Michaels Hosp, Dept Anesthesia, Toronto, ON, Canada.;Univ Toronto, Toronto, ON, Canada.;Natl Univ Ireland Galway, Sch Med, Galway, Ireland.;Natl Univ Ireland Galway, Regenerat Med Inst IREMEDI, CURAM Ctr Res Med Devices, Galway, Ireland.
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Unity Heath Toronto, Li Ka Shing Knowledge Inst, Keenan Res Ctr, St Michaels Hosp, Toronto, ON, Canada;Univ Toronto, Interdept Div Crit Care Med, Toronto, ON, Canada.;Univ Paris Saclay, Serv Med Intens Reanimat, Grp Rech Clin CARMAS, Hop Bicetre,AP HP,FHU SEPSIS,DMU CORREVE, Le Kremlin Bicetre, France.;Univ Paris Saclay, Univ Paris Sud, CESP, Equipe Epidemiol Resp Integrat,UVSQ,Inserm, Villejuif, France. Osped Maggiore Policlin, Fdn IRCCS Ca Granda, Dipartimento Anestesia Rianimaz Emergenza Urgenza, Milan, Italy.;Univ Milan, Dipartimento Fisiopatol Med Chirurg & Trapianti, Milan, Italy. (creator_code:org_t)
2020-12-17
2021
Engelska.
Ingår i: European Respiratory Journal. - : European Respiratory Society. - 0903-1936 .- 1399-3003. ; 57:6
Relaterad länk:
https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Background: Current incidence and outcome of patients with acute hypoxaemic respiratory failure requiring mechanical ventilation in the intensive care unit (ICU) are unknown, especially for patients not meeting criteria for acute respiratory distress syndrome (ARDS). Methods: An international, multicentre, prospective cohort study of patients presenting with hypoxaemia early in the course of mechanical ventilation, conducted during four consecutive weeks in the winter of 2014 in 459 ICUs from 50 countries (LUNG SAFE). Patients were enrolled with arterial oxygen tension/inspiratory oxygen fraction ratio <= 300 mmHg, new pulmonary infiltrates and need for mechanical ventilation with a positive end-expiratory pressure of >= 5 cmH(2)O. ICU prevalence, causes of hypoxaemia, hospital survival and factors associated with hospital mortality were measured. Patients with unilateral versus bilateral opacities were compared. Findings: 12 906 critically ill patients received mechanical ventilation and 34.9% with hypoxaemia and new infiltrates were enrolled, separated into ARDS (69.0%), unilateral infiltrate (22.7%) and congestive heart failure (CHF; 8.2%). The global hospital mortality was 38.6%. CHF patients had a mortality comparable to ARDS (44.1% versus 40.4%). Patients with unilateral-infiltrate had lower unadjusted mortality, but similar adjusted mortality compared to those with ARDS. The number of quadrants on chest imaging was associated with an increased risk of death. There was no difference in mortality comparing patients with unilateral-infiltrate and ARDS with only two quadrants involved. Interpretation: More than one-third of patients receiving mechanical ventilation have hypoxaemia and new infiltrates with a hospital mortality of 38.6%. Survival is dependent on the degree of pulmonary involvement whether or not ARDS criteria are reached.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)

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