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High Density of NRF...
High Density of NRF2 Expression in Malignant Cells Is Associated with Increased Risk of CNS Metastasis in Early-Stage NSCLC
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- Tsakonas, Georgios (författare)
- Karolinska Institutet
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- Martin-Bernabe, Alfonso (författare)
- Karolinska Institutet
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- Rounis, Konstantinos (författare)
- Karolinska Univ Hosp, Thorac Oncol Ctr, Theme Canc, S-17164 Solna, Sweden.
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- Moreno-Ruiz, Pablo (författare)
- Karolinska Inst, Dept Oncol Pathol, S-17164 Stockholm, Sweden.
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- Botling, Johan (författare)
- Uppsala universitet,Klinisk och experimentell patologi,Johan Botling
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- De Petris, Luigi (författare)
- Karolinska Institutet
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- Ylipää, Antti (författare)
- Genevia Technol Oy, Tampere 33100, Finland.
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- Mezheyeuski, Artur (författare)
- Uppsala universitet,Experimentell och klinisk onkologi
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- Micke, Patrick (författare)
- Uppsala universitet,Klinisk och experimentell patologi,Patrick Micke
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- Östman, Arne (författare)
- Karolinska Institutet
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- Ekman, Simon (författare)
- Karolinska Institutet
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Karolinska Institutet Karolinska Univ Hosp, Thorac Oncol Ctr, Theme Canc, S-17164 Solna, Sweden (creator_code:org_t)
- 2021-06-24
- 2021
- Engelska.
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Ingår i: Cancers. - : MDPI. - 2072-6694. ; 13:13
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://www.mdpi.com...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Simple Summary We retrospectively analyzed 304 patients with surgically removed non-small cell lung cancer (NSCLC). Multiplex antibody staining of nuclear factor erythroid 2-related factor 2 (NRF2) and thioredoxin reductase 1 (TrxR1) was conducted and scored in cytokeratin-positive (CK+) cells within the whole-tissue core as well as the tumor and stromal compartments of each tissue microarray (TMA) core. A high density of NRF2+/CK+ cells in the whole-tissue core compartment was an independent prognostic factor, with an eightfold increase in odds regarding the risk of relapse in the central nervous system (CNS). This is the first study to report a tumor-cell-associated protein biomarker for CNS relapse in early-stage lung cancer and the first trial to report the correlation between NRF2 expression and risk of CNS relapse. The results of our study may have an impact on the follow-up strategy for early-stage NSCLC patients and eventually improve their prognosis. Nuclear factor erythroid 2-related factor 2 (NRF2) protein expression promotes cancer progression in non-small cell lung cancer (NSCLC). However, its role in the clinical setting has not been established. We retrospectively analyzed data from 304 patients with surgically removed NSCLC. Multiplex antibody staining of NRF2 and thioredoxin reductase 1 (TrxR1) was conducted and scored in cytokeratin-positive (CK+) cells within the whole-tissue core as well as the tumor and stromal compartments of each tissue microarray (TMA) core. A high density of NRF2+/CK+ cells in the whole-tissue core compartment was correlated with a higher risk of central nervous system (CNS) relapse OR = 7.36 (95% CI: 1.64-33.06). The multivariate analysis showed an OR = 8.00 (95% CI: 1.70-37.60) for CNS relapse in NRF2+/CK+ high-density cases. The density of TrxR1+/CK+ cells failed to show any statistically significant risk of relapse. The OS analyses for NRF2+/CK+ and TrxR1+/CK+ cell density failed to show any statistical significance. This is the first study to report a correlation between NRF2+/CK+ cell density and the risk of CNS relapse in early-stage NSCLC. The results of our study may impact the follow-up strategy for early-stage NSCLC patients and eventually improve their prognosis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
Nyckelord
- brain metastases
- non-small cell lung cancer
- NRF2
- TrxR1
- Pathology
- Patologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Cancers
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Tsakonas, Georgi ...
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Martin-Bernabe, ...
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Rounis, Konstant ...
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Moreno-Ruiz, Pab ...
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Botling, Johan
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De Petris, Luigi
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Ylipää, Antti
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Mezheyeuski, Art ...
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Micke, Patrick
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Östman, Arne
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Ekman, Simon
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