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Metagenomic charact...
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Isa, Khairul Nizam MohdUniv Putra Malaysia, Fac Med & Hlth Sci, Dept Environm & Occupat Hlth, UPM, Serdang 43400, Selangor, Malaysia.;Univ Kuala Lumpur, Inst Med Sci Technol, Environm Healthcare Sect, Environm Hlth Res Cluster EHRc, Kajang, Selangor, Malaysia.
(författare)
Metagenomic characterization of indoor dust fungal associated with allergy and lung inflammation among school children
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
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Elsevier,2021
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-452449
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-452449URI
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https://doi.org/10.1016/j.ecoenv.2021.112430DOI
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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The exposure of school children to indoor air pollutants has increased allergy and respiratory diseases. The objective of this study were to determine the toxicodynamic interaction of indoor pollutants exposure, biological and chemical with expression of adhesion molecules on eosinophil and neutrophil. A self-administered questionnaire, allergy skin test, and fractional exhaled nitric oxide (FeNO) analyser were used to collect information on health status, sensitization to allergens and respiratory inflammation, respectively among school children at age of 14 years. The sputum induced were analysed to determine the expression of CD11b, CD35, CD63 and CD66b on eosinophil and neutrophil by using flow cytometry technique. The particulate matter (PM2.5 and PM10), NO2, CO2, and formaldehyde, temperature, and relative humidity were measured inside the classrooms. The fungal DNA were extracted from settled dust collected from classrooms and evaluated using metagenomic techniques. We applied chemometric and regression in statistical analysis. A total of 1869 unique of operational taxonomic units (OTUs) of fungi were identified with dominated at genus level by Aspergillus (15.8%), Verrucoconiothyrium (5.5%), and Ganoderma (4.6%). Chemometric and regression results revealed that relative abundance of T. asahii were associated with down regulation of CD66b expressed on eosinophil, and elevation of FeNO levels in predicting asthmatic children with model accuracy of 63.6%. Meanwhile, upregulation of CD11b expressed on eosinophil were associated with relative abundance of A. clavatus and regulated by PM2.5. There were significant association of P. bandonii with upregulation of CD63 expressed on neutrophil and exposure to NO2. Our findings indicate that exposure to PM2.5, NO2, T. asahii, P.bandonii and A.clavatus are likely interrelated with upregulation of activation and degranulation markers on both eosinophil and neutrophil.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Jalaludin, JulianaUniv Putra Malaysia, Fac Med & Hlth Sci, Dept Environm & Occupat Hlth, UPM, Serdang 43400, Selangor, Malaysia.
(författare)
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Elias, Saliza MohdUniv Putra Malaysia, Fac Med & Hlth Sci, Dept Environm & Occupat Hlth, UPM, Serdang 43400, Selangor, Malaysia.
(författare)
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Than, Leslie Thian LungUniv Putra Malaysia, Fac Med & Hlth Sci, Dept Med Microbiol & Parasitol, UPM, Serdang 43400, Selangor, Malaysia.
(författare)
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Jabbar, Mohammed AbdulrazzaqUniv Tunku Abdul Rahman, Fac Med & Hlth Sci, Dept Populat Med, Jalan Sungai Long, Kajang, Selangor, Malaysia.
(författare)
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Saudi, Ahmad Shakir MohdUniv Kuala Lumpur, Inst Med Sci Technol, Environm Healthcare Sect, Environm Hlth Res Cluster EHRc, Kajang, Selangor, Malaysia.
(författare)
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Norbäck, DanUppsala universitet,Arbets- och miljömedicin(Swepub:uu)dagnorba
(författare)
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Hashim, Jamal HishamUniv Selangor, Fac Engn & Life Sci, Dept Hlth Sci, Shah Alam Campus,Seksyen 7, Shah Alam, Selangor, Malaysia.
(författare)
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Hashim, ZailinaUniv Putra Malaysia, Fac Med & Hlth Sci, Dept Environm & Occupat Hlth, UPM, Serdang 43400, Selangor, Malaysia.
(författare)
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Univ Putra Malaysia, Fac Med & Hlth Sci, Dept Environm & Occupat Hlth, UPM, Serdang 43400, Selangor, Malaysia.;Univ Kuala Lumpur, Inst Med Sci Technol, Environm Healthcare Sect, Environm Hlth Res Cluster EHRc, Kajang, Selangor, Malaysia.Univ Putra Malaysia, Fac Med & Hlth Sci, Dept Environm & Occupat Hlth, UPM, Serdang 43400, Selangor, Malaysia.
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Ecotoxicology and Environmental Safety: Elsevier2210147-65131090-2414
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