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Prevalence and dete...
Prevalence and determinants of serum antibodies to SARS-CoV-2 in the general population of the Gardena valley
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- Melotti, Roberto (author)
- Univ Lubeck, Eurac Res, Inst Biomed, Bolzano, Italy.
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- Scaggiante, Federica (author)
- Hosp Bressanone SABES ASDAA, Lab Patol Clin Bressanone, Bressanone Brixen, Italy.
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- Falciani, Michela (author)
- Hosp Bolzano SABES ASDAA, Serv Farmaceut, Bolzano, Italy.
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- Weichenberger, Christian X. (author)
- Univ Lubeck, Eurac Res, Inst Biomed, Bolzano, Italy.
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- Foco, Luisa (author)
- Univ Lubeck, Eurac Res, Inst Biomed, Bolzano, Italy.
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- Lombardo, Stefano (author)
- Ist Prov Stat ASTAT, Bolzano, Amministrazione, Italy.
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- De Grandi, Alessandro (author)
- Univ Lubeck, Eurac Res, Inst Biomed, Bolzano, Italy.
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- von Laer, Dorothee (author)
- Innsbruck Med Univ, Dept Hyg Microbiol & Publ Hlth, Inst Virol, Innsbruck, Austria.
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- Mahlknecht, Angelika (author)
- Scuola Prov Super Sanita Claudiana, Ist Med Gen, Bolzano, Italy.;Paracelsus Med Univ, Inst Gen Practice Family Med & Prevent Med, Salzburg, Austria.
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- Pramstaller, Peter P. (author)
- Univ Lubeck, Eurac Res, Inst Biomed, Bolzano, Italy.
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- Pagani, Elisabetta (author)
- Hosp Bolzano SABES ASDAA, Lab Aziendale Microbiol & Virol, Bolzano, Italy.
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- Meier, Horand (author)
- Unita Operat Governo Clin, Bolzano, Amministrazione, Italy.
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- Gaertner, Timon (author)
- Ist Prov Stat ASTAT, Bolzano, Amministrazione, Italy.
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- Troi, Christina (author)
- Hosp Bressanone SABES ASDAA, Lab Patol Clin Bressanone, Bressanone Brixen, Italy.
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- Mascalzoni, Deborah, 1973- (author)
- Uppsala universitet,Centrum för forsknings- och bioetik,Univ Lubeck, Eurac Res, Inst Biomed, Bolzano, Italy.
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- Pattaro, Cristian (author)
- Univ Lubeck, Eurac Res, Inst Biomed, Bolzano, Italy.
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- Mian, Michael (author)
- Hosp Bolzano SABES ASDAA, Serv Innovat Res & Teaching, Bolzano, Italy.;Scuola Prov Super Sanita Claudiana, Bolzano, Italy.
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Univ Lubeck, Eurac Res, Inst Biomed, Bolzano, Italy Hosp Bressanone SABES ASDAA, Lab Patol Clin Bressanone, Bressanone Brixen, Italy. (creator_code:org_t)
- Cambridge University Press, 2021
- 2021
- English.
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In: Epidemiology and Infection. - : Cambridge University Press. - 0950-2688 .- 1469-4409. ; 149
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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Abstract
Subject headings
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- Estimating the spread of SARS-CoV-2 infection in communities is critical. We surveyed 2244 stratified random sample community members of the Gardena valley, a winter touristic area, amidst the first expansion phase of the COVID-19 pandemic in Europe. We measured agreement between Diasorin and Abbott serum bioassay outputs and the Abbott optimal discriminant threshold of serum neutralisation titres with recursive receiver operating characteristic curve. We analytically adjusted serum antibody tests for unbiased seroprevalence estimate and analysed the determinants of infection with non-response weighted multiple logistic regression. SARS-CoV-2 seroprevalence was 26.9% (95% CI 25.2-28.6) by June 2020. The bioassays had a modest agreement with each other. At a lower threshold than the manufacturer's recommended level, the Abbott assay reflected greater discrimination of serum neutralisation capacity. Seropositivity was associated with place and economic activity, not with sex or age. Symptoms like fever and weakness were age-dependent. SARS-CoV-2 mitigation strategies should account for context in high prevalence areas.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Keyword
- Coronavirus
- COVID-19
- neutralising antibodies
- prevalence
- SARS-CoV-2
Publication and Content Type
- ref (subject category)
- art (subject category)
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Melotti, Roberto
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Scaggiante, Fede ...
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Falciani, Michel ...
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Weichenberger, C ...
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Foco, Luisa
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Lombardo, Stefan ...
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De Grandi, Aless ...
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von Laer, Doroth ...
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Mahlknecht, Ange ...
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Pramstaller, Pet ...
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Pagani, Elisabet ...
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Meier, Horand
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Gaertner, Timon
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Troi, Christina
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Mascalzoni, Debo ...
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Pattaro, Cristia ...
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Mian, Michael
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
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Epidemiology and ...
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Uppsala University