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SARS-CoV-2 Spike Pr...
SARS-CoV-2 Spike Protein Extrapolation for COVID Diagnosis and Vaccine Development
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- Malik, Yashpal S. (författare)
- ICAR Indian Vet Res Inst, Div Biol Standardizat, Bareilly, Uttar Pradesh, India.;Guru Angad Dev Vet & Anim Sci Univ, Coll Anim Biotechnol, Ludhiana, Punjab, India.
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- Kumar, Prashant (författare)
- Amity Univ, Amity Inst Virol & Immunol, Noida, India.
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- Ansari, Mohd Ikram (författare)
- ICAR Indian Vet Res Inst, Div Biol Standardizat, Bareilly, Uttar Pradesh, India.;Integral Univ, Dept Biosci, Lucknow, Uttar Pradesh, India.
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- Hemida, Maged G. (författare)
- King Faisal Univ, Coll Vet Med, Dept Microbiol, Al Hufuf, Saudi Arabia.;Kafrelsheikh Univ, Fac Vet Med, Dept Virol, Kafr El Shaikh, Egypt.
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- El Zowalaty, Mohamed E. (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Abdel-Moneim, Ahmed S. (författare)
- Taif Univ, Coll Med, Microbiol Dept, Al Taif, Saudi Arabia.;Beni Suef Univ, Fac Vet Med, Virol Dept, Bani Suwayf, Egypt.
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- Ganesh, Balasubramanian (författare)
- Minist Hlth & Family Welf, Natl Inst Epidemiol, Indian Council Med Res, Lab Div, Chennai, Tamil Nadu, India.
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- Salajegheh, Sina (författare)
- Islamic Azad Univ, Sci & Res Branch, Young Researchers & Elites Club, Tehran, Iran.;Islamic Azad Univ, Sci & Res Branch, Fac Vet Med, Tehran, Iran.
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- Natesan, Senthilkumar (författare)
- Indian Inst Publ Hlth Gandhinagar, Gandhinagar, India.
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- Sircar, Shubhankar (författare)
- ICAR Indian Vet Res Inst, Div Biol Standardizat, Bareilly, Uttar Pradesh, India.
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- Safdar, Muhammad (författare)
- Cholistan Univ Vet & Anim Sci, Dept Breeding & Genet, Bahawalpur, Pakistan.
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- Vinodhkumar, O. R. (författare)
- ICAR Indian Vet Res Inst, Div Epidemiol, Bareilly, Uttar Pradesh, India.
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- Duarte, Phelipe M. (författare)
- Univ Cuiaba, Fac Biol & Hlth Sci, Primavera Do Leste, Brazil.
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- Patel, Shailesh K. (författare)
- ICAR Indian Vet Res Inst, Div Pathol, Bareilly, Uttar Pradesh, India.
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- Klein, Jorn (författare)
- Univ Cuiaba, Fac Biol & Hlth Sci, Primavera Do Leste, Brazil.;Univ South Eastern Norway, Fac Hlth & Social Sci, Kongsberg, Norway.
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- Rahimi, Parastoo (författare)
- Islamic Azad Univ, Sci & Res Branch, Fac Vet Med, Tehran, Iran.
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- Dhama, Kuldeep (författare)
- ICAR Indian Vet Res Inst, Div Pathol, Bareilly, Uttar Pradesh, India.
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ICAR Indian Vet Res Inst, Div Biol Standardizat, Bareilly, Uttar Pradesh, India;Guru Angad Dev Vet & Anim Sci Univ, Coll Anim Biotechnol, Ludhiana, Punjab, India. Amity Univ, Amity Inst Virol & Immunol, Noida, India. (creator_code:org_t)
- 2021-07-28
- 2021
- Engelska.
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Ingår i: Frontiers in Molecular Biosciences. - : Frontiers Media S.A.. - 2296-889X. ; 8
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://www.frontier...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) led to coronavirus disease 2019 (COVID-19) pandemic affecting nearly 71.2 million humans in more than 191 countries, with more than 1.6 million mortalities as of 12 December, 2020. The spike glycoprotein (S-protein), anchored onto the virus envelope, is the trimer of S-protein comprised of S1 and S2 domains which interacts with host cell receptors and facilitates virus-cell membrane fusion. The S1 domain comprises of a receptor binding domain (RBD) possessing an N-terminal domain and two subdomains (SD1 and SD2). Certain regions of S-protein of SARS-CoV-2 such as S2 domain and fragment of the RBD remain conserved despite the high selection pressure. These conserved regions of the S-protein are extrapolated as the potential target for developing molecular diagnostic techniques. Further, the S-protein acts as an antigenic target for different serological assay platforms for the diagnosis of COVID-19. Virus-specific IgM and IgG antibodies can be used to detect viral proteins in ELISA and lateral flow immunoassays. The S-protein of SARS-CoV-2 has very high sequence similarity to SARS-CoV-1, and the monoclonal antibodies (mAbs) against SARS-CoV-1 cross-react with S-protein of SARS-CoV-2 and neutralize its activity. Furthermore, in vitro studies have demonstrated that polyclonal antibodies targeted against the RBD of S-protein of SARS-CoV-1 can neutralize SARS-CoV-2 thus inhibiting its infectivity in permissive cell lines. Research on coronaviral S-proteins paves the way for the development of vaccines that may prevent SARS-CoV-2 infection and alleviate the current global coronavirus pandemic. However, specific neutralizing mAbs against SARS-CoV-2 are in clinical development. Therefore, neutralizing antibodies targeting SARS-CoV-2 S-protein are promising specific antiviral therapeutics for pre-and post-exposure prophylaxis and treatment of SARS-CoV-2 infection. We hereby review the approaches taken by researchers across the world to use spike gene and S-glycoprotein for the development of effective diagnostics, vaccines and therapeutics against SARA-CoV-2 infection the COVID-19 pandemic.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- COVID-19
- coronavirus pandemic
- SARS-CoV-2
- S-protein
- diagnosis
- vaccines
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Malik, Yashpal S ...
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Kumar, Prashant
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Ansari, Mohd Ikr ...
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Hemida, Maged G.
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El Zowalaty, Moh ...
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Abdel-Moneim, Ah ...
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Ganesh, Balasubr ...
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Salajegheh, Sina
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Natesan, Senthil ...
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Sircar, Shubhank ...
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Safdar, Muhammad
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Vinodhkumar, O. ...
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Duarte, Phelipe ...
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Patel, Shailesh ...
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Klein, Jorn
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Rahimi, Parastoo
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Dhama, Kuldeep
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