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  • Almby, Kristina E.Uppsala universitet,Klinisk diabetologi och metabolism,Department of Medical Sciences, Clinical Diabetes and Metabolism, Uppsala University, Uppsala, Sweden (author)

Effects of Gastric Bypass Surgery on the Brain : Simultaneous Assessment of Glucose Uptake, Blood Flow, Neural Activity, and Cognitive Function During Normo- and Hypoglycemia

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2021-03-04
  • American Diabetes Association,2021
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-452976
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-452976URI
  • https://doi.org/10.2337/db20-1172DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-186582URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • K.E.A. and M.H.L. contributed equally.
  • While Roux-en-Y gastric bypass (RYGB) surgery in obese individuals typically improves glycemic control and prevents diabetes, it also frequently causes asymptomatic hypoglycemia. Previous work showed attenuated counterregulatory responses following RYGB. The underlying mechanisms as well as the clinical consequences are unclear. In this study, 11 subjects without diabetes with severe obesity were investigated pre- and post-RYGB during hyperinsulinemic normo-hypoglycemic clamps. Assessments were made of hormones, cognitive function, cerebral blood flow by arterial spin labeling, brain glucose metabolism by F-18-fluorodeoxyglucose (FDG) positron emission tomography, and activation of brain networks by functional MRI. Post- versus presurgery, we found a general increase of cerebral blood flow but a decrease of total brain FDG uptake during normoglycemia. During hypoglycemia, there was a marked increase in total brain FDG uptake, and this was similar for post- and presurgery, whereas hypothalamic FDG uptake was reduced during hypoglycemia. During hypoglycemia, attenuated responses of counterregulatory hormones and improvements in cognitive function were seen postsurgery. In early hypoglycemia, there was increased activation post- versus presurgery of neural networks in brain regions implicated in glucose regulation, such as the thalamus and hypothalamus. The results suggest adaptive responses of the brain that contribute to lowering of glycemia following RYGB, and the underlying mechanisms should be further elucidated.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Lundqvist, Martin H.Uppsala universitet,Klinisk diabetologi och metabolism,Department of Medical Sciences, Clinical Diabetes and Metabolism, Uppsala University, Uppsala, Sweden(Swepub:uu)marlu858 (author)
  • Abrahamsson, Niclas,1976-Uppsala universitet,Klinisk diabetologi och metabolism,Department of Medical Sciences, Clinical Diabetes and Metabolism, Uppsala University, Uppsala, Sweden(Swepub:uu)nicab972 (author)
  • Kvernby, SofiaUppsala universitet,Radiologi,Department of Surgical Sciences, Uppsala University, Uppsala, Sweden(Swepub:uu)sofkv986 (author)
  • Fahlström, MarkusUppsala universitet,Radiologi,Department of Surgical Sciences, Uppsala University, Uppsala, Sweden(Swepub:uu)marfa863 (author)
  • Pereira, Maria J.,1981-Uppsala universitet,Klinisk diabetologi och metabolism,Department of Medical Sciences, Clinical Diabetes and Metabolism, Uppsala University, Uppsala, Sweden(Swepub:uu)marpe927 (author)
  • Gingnell, Malin,1982-Uppsala universitet,Institutionen för psykologi,Cervenka: Psykiatri,Department of Neurosciences and Department of Psychology, Uppsala University, Uppsala, Sweden(Swepub:uu)malgi638 (author)
  • Karlsson, Anders,1945-Uppsala universitet,Klinisk diabetologi och metabolism,Department of Medical Sciences, Clinical Diabetes and Metabolism, Uppsala University, Uppsala, Sweden(Swepub:uu)anderska (author)
  • Fanni, GiovanniUppsala universitet,Klinisk diabetologi och metabolism,Department of Medical Sciences, Clinical Diabetes and Metabolism, Uppsala University, Uppsala, Sweden(Swepub:uu)giofa361 (author)
  • Sundbom, MagnusUppsala universitet,Gastrointestinalkirurgi,Department of Surgical Sciences, Uppsala University, Uppsala, Sweden(Swepub:uu)magsundb (author)
  • Wiklund, UrbanUmeå universitet,Radiofysik,Umeå Univ, Dept Radiat Sci, Umeå, Sweden.(Swepub:umu)urwi0001 (author)
  • Haller, SvenUppsala universitet,Radiologi,Univ Geneva, Fac Med, Geneva, Switzerland.,Department of Surgical Sciences, Uppsala University, Uppsala, Sweden; Faculty of Medicine, University of Geneva, Geneva, Switzerland(Swepub:uu)sveha228 (author)
  • Lubberink, MarkUppsala universitet,Radiologi,Department of Surgical Sciences, Uppsala University, Uppsala, Sweden(Swepub:uu)marklubb (author)
  • Wikström, Johan,1964-Uppsala universitet,Radiologi,Department of Surgical Sciences, Uppsala University, Uppsala, Sweden(Swepub:uu)jwi06759 (author)
  • Eriksson, JanUppsala universitet,Klinisk diabetologi och metabolism,Department of Medical Sciences, Clinical Diabetes and Metabolism, Uppsala University, Uppsala, Sweden(Swepub:uu)janer909 (author)
  • Uppsala universitetKlinisk diabetologi och metabolism (creator_code:org_t)

Related titles

  • In:Diabetes: American Diabetes Association70:6, s. 1265-12770012-17971939-327X

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