Maternal and Infant Factors Influencing Human Milk Oligosaccharide Composition: Beyond Maternal Genetics

Maternal and Infant Factors Influencing Human Milk Oligosaccharide Composition : Beyond Maternal Genetics

Maternal genetics is a key determinant of human milk oligosaccharide (HMO) composition in human milk. Beyond genetic status, other factors influencing the HMO profile are poorly defined. Thus, we aimed to review the existing evidence on the associations between nongenetic maternal and infant factors and HMO composition. A systematic search was performed on PubMed and Web of Science (without a time restriction) to identify any relevant studies published. In total, 1056 results were obtained, of which 29 articles were selected to be included in this review. The range of factors investigated include lactation stage, maternal pre-pregnancy BMI (ppBMI), maternal age, parity, maternal diet, mode of delivery, infant gestational age, and infant sex. The data suggest that, beyond maternal genetics, HMO composition seems to be influenced by all these factors, but the underlining mechanisms remain speculative. The published evidence is discussed in this review, along with potential implications for infant growth and development. For example, 2'-fucosyllactose, which was reportedly increased in mothers with higher ppBMIs, was also associated with increased infant weight and height. In addition, greater levels of sialylated HMOs after preterm birth may support brain development in these infants.

Derraik, José G. B.Uppsala universitet,Perinatal, neonatal och barnkardiologisk forskning,Univ Auckland, Liggins Inst, Auckland, New Zealand; Zhejiang Univ, Childrens Hosp, Dept Endocrinol, Sch Med, Hangzhou, Peoples R China(Swepub:uu)josde820 (författare)
Binia, AristeaSoc Produits Nestle SA, Nestle Res, Lausanne, Switzerland (författare)
Sprenger, NorbertSoc Produits Nestle SA, Nestle Res, Lausanne, Switzerland (författare)
Vickers, Mark H.Univ Auckland, Liggins Inst, Auckland, New Zealand (författare)
Cutfield, Wayne S.Univ Auckland, Liggins Inst, Auckland, New Zealand; Univ Auckland, Better Start Natl Sci Challenge, Auckland, New Zealand (författare)
Univ Auckland, Liggins Inst, Auckland, New ZealandPerinatal, neonatal och barnkardiologisk forskning (creator_code:org_t)

Av författaren/redakt...: Han, Soo Min; Derraik, José G. ...; Binia, Aristea; Sprenger, Norber ...; Vickers, Mark H.; Cutfield, Wayne ...

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