A meta-analysis of deep brain structural shape and asymmetry abnormalities in 2,833 individuals with schizophrenia compared with 3,929 healthy volunteers via the ENIGMA Consortium

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Gutman, Boris A (author)

A meta-analysis of deep brain structural shape and asymmetry abnormalities in 2,833 individuals with schizophrenia compared with 3,929 healthy volunteers via the ENIGMA Consortium

Article/chapterEnglish2022

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2021-09-08
John Wiley & Sons,2022
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LIBRIS-ID:oai:DiVA.org:uu-453372
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-453372URI
https://doi.org/10.1002/hbm.25625DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:147597035URI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Schizophrenia is associated with widespread alterations in subcortical brain structure. While analytic methods have enabled more detailed morphometric characterization, findings are often equivocal. In this meta-analysis, we employed the harmonized ENIGMA shape analysis protocols to collaboratively investigate subcortical brain structure shape differences between individuals with schizophrenia and healthy control participants. The study analyzed data from 2,833 individuals with schizophrenia and 3,929 healthy control participants contributed by 21 worldwide research groups participating in the ENIGMA Schizophrenia Working Group. Harmonized shape analysis protocols were applied to each site's data independently for bilateral hippocampus, amygdala, caudate, accumbens, putamen, pallidum, and thalamus obtained from T1-weighted structural MRI scans. Mass univariate meta-analyses revealed more-concave-than-convex shape differences in the hippocampus, amygdala, accumbens, and thalamus in individuals with schizophrenia compared with control participants, more-convex-than-concave shape differences in the putamen and pallidum, and both concave and convex shape differences in the caudate. Patterns of exaggerated asymmetry were observed across the hippocampus, amygdala, and thalamus in individuals with schizophrenia compared to control participants, while diminished asymmetry encompassed ventral striatum and ventral and dorsal thalamus. Our analyses also revealed that higher chlorpromazine dose equivalents and increased positive symptom levels were associated with patterns of contiguous convex shape differences across multiple subcortical structures. Findings from our shape meta-analysis suggest that common neurobiological mechanisms may contribute to gray matter reduction across multiple subcortical regions, thus enhancing our understanding of the nature of network disorganization in schizophrenia.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Psykiatri hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Psychiatry hsv//eng
schizophrenia
structure
subcortical shape

Added entries (persons, corporate bodies, meetings, titles ...)

van Erp, Theo G M (author)
Alpert, Kathryn (author)
Ching, Christopher R K (author)
Isaev, Dmitry (author)
Ragothaman, Anjani (author)
Jahanshad, Neda (author)
Saremi, Arvin (author)
Zavaliangos-Petropulu, Artemis (author)
Glahn, David C (author)
Shen, Li (author)
Cong, Shan (author)
Alnaes, Dag (author)
Andreassen, Ole Andreas (author)
Doan, Nhat Trung (author)
Westlye, Lars T (author)
Kochunov, Peter (author)
Satterthwaite, Theodore D (author)
Wolf, Daniel H (author)
Huang, Alexander J (author)
Kessler, Charles (author)
Weideman, Andrea (author)
Nguyen, Dana (author)
Mueller, Bryon A (author)
Faziola, Lawrence (author)
Potkin, Steven G (author)
Preda, Adrian (author)
Mathalon, Daniel H (author)
Bustillo, Juan (author)
Calhoun, Vince (author)
Ford, Judith M (author)
Walton, Esther (author)
Ehrlich, Stefan (author)
Ducci, Giuseppe (author)
Banaj, Nerisa (author)
Piras, Fabrizio (author)
Piras, Federica (author)
Spalletta, Gianfranco (author)
Canales-Rodríguez, Erick J (author)
Fuentes-Claramonte, Paola (author)
Pomarol-Clotet, Edith (author)
Radua, Joaquim (author)
Salvador, Raymond (author)
Sarró, SalvadorKarolinska Institutet (author)
Dickie, Erin W (author)
Voineskos, Aristotle (author)
Tordesillas-Gutiérrez, Diana (author)
Crespo-Facorro, Benedicto (author)
Setién-Suero, Esther (author)
van Son, Jacqueline Mayoral (author)
Borgwardt, Stefan (author)
Schönborn-Harrisberger, Fabienne (author)
Morris, Derek (author)
Donohoe, Gary (author)
Holleran, Laurena (author)
Cannon, Dara (author)
McDonald, ColmKarolinska Institutet (author)
Corvin, Aiden (author)
Gill, Michael (author)
Filho, Geraldo Busatto (author)
Rosa, Pedro G P (author)
Serpa, Mauricio H (author)
Zanetti, Marcus V (author)
Lebedeva, Irina (author)
Kaleda, Vasily (author)
Tomyshev, Alexander (author)
Crow, Tim (author)
James, Anthony (author)
Cervenka, Simon (author)
Sellgren, Carl M (author)
Fatouros-Bergman, HelenaKarolinska Institutet (author)
Agartz, IngridKarolinska Institutet (author)
Howells, Fleur (author)
Stein, Dan J (author)
Temmingh, Henk (author)
Uhlmann, Anne (author)
de Zubicaray, Greig I (author)
McMahon, Katie L (author)
Wright, Margie (author)
Cobia, Derin (author)
Csernansky, John G (author)
Thompson, Paul M (author)
Turner, Jessica A (author)
Wang, Lei (author)
Karolinska Institutet (creator_code:org_t)

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In:Human Brain Mapping: John Wiley & Sons43:1, s. 352-3721065-94711097-0193

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By the author/editor: Gutman, Boris A; van Erp, Theo G ...; Alpert, Kathryn; Ching, Christoph ...; Isaev, Dmitry; Ragothaman, Anja ...; show more...; Jahanshad, Neda; Saremi, Arvin; Zavaliangos-Petr ...; Glahn, David C; Shen, Li; Cong, Shan; Alnaes, Dag; Andreassen, Ole ...; Doan, Nhat Trung; Westlye, Lars T; Kochunov, Peter; Satterthwaite, T ...; Wolf, Daniel H; Huang, Alexander ...; Kessler, Charles; Weideman, Andrea; Nguyen, Dana; Mueller, Bryon A; Faziola, Lawrenc ...; Potkin, Steven G; Preda, Adrian; Mathalon, Daniel ...; Bustillo, Juan; Calhoun, Vince; Ford, Judith M; Walton, Esther; Ehrlich, Stefan; Ducci, Giuseppe; Banaj, Nerisa; Piras, Fabrizio; Piras, Federica; Spalletta, Gianf ...; Canales-Rodrígue ...; Fuentes-Claramon ...; Pomarol-Clotet, ...; Radua, Joaquim; Salvador, Raymon ...; Sarró, Salvador; Dickie, Erin W; Voineskos, Arist ...; Tordesillas-Guti ...; Crespo-Facorro, ...; Setién-Suero, Es ...; van Son, Jacquel ...; Borgwardt, Stefa ...; Schönborn-Harris ...; Morris, Derek; Donohoe, Gary; Holleran, Lauren ...; Cannon, Dara; McDonald, Colm; Corvin, Aiden; Gill, Michael; Filho, Geraldo B ...; Rosa, Pedro G P; Serpa, Mauricio ...; Zanetti, Marcus ...; Lebedeva, Irina; Kaleda, Vasily; Tomyshev, Alexan ...; Crow, Tim; James, Anthony; Cervenka, Simon; Sellgren, Carl M; Fatouros-Bergman ...; Agartz, Ingrid; Howells, Fleur; Stein, Dan J; Temmingh, Henk; Uhlmann, Anne; de Zubicaray, Gr ...; McMahon, Katie L; Wright, Margie; Cobia, Derin; Csernansky, John ...; Thompson, Paul M; Turner, Jessica ...; Wang, Lei; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Psychiatry

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By the university: Uppsala University; Karolinska Institutet

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