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  • Zhou, SiruiMcGill Univ, Lady Davis Inst, Jewish Gen Hosp, Montreal, PQ, Canada.;McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ, Canada.,Lady Davis Institute, Jewish General Hospital, McGill University, QC, Montréal, Canada; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, QC, Montréal, Canada (författare)

A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • 2021-02-25
  • Springer Nature,2021
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-453856
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-453856URI
  • https://doi.org/10.1038/s41591-021-01281-1DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:145893321URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-181557URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • To identify circulating proteins influencing Coronavirus Disease 2019 (COVID-19) susceptibility and severity, we undertook a two-sample Mendelian randomization (MR) study, rapidly scanning hundreds of circulating proteins while reducing bias due to reverse causation and confounding. In up to 14,134 cases and 1.2 million controls, we found that an s.d. increase in OAS1 levels was associated with reduced COVID-19 death or ventilation (odds ratio (OR) = 0.54, P = 7 × 10−8), hospitalization (OR = 0.61, P = 8 × 10−8) and susceptibility (OR = 0.78, P = 8 × 10−6). Measuring OAS1 levels in 504 individuals, we found that higher plasma OAS1 levels in a non-infectious state were associated with reduced COVID-19 susceptibility and severity. Further analyses suggested that a Neanderthal isoform of OAS1 in individuals of European ancestry affords this protection. Thus, evidence from MR and a case–control study support a protective role for OAS1 in COVID-19 adverse outcomes. Available pharmacological agents that increase OAS1 levels could be prioritized for drug development.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Butler-Laporte, GuillaumeMcGill Univ, Lady Davis Inst, Jewish Gen Hosp, Montreal, PQ, Canada.;McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ, Canada.,Lady Davis Institute, Jewish General Hospital, McGill University, QC, Montréal, Canada; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, QC, Montréal, Canada (författare)
  • Nakanishi, TomokoMcGill Univ, Lady Davis Inst, Jewish Gen Hosp, Montreal, PQ, Canada.;McGill Univ, Dept Human Genet, Montreal, PQ, Canada.;Kyoto Univ, Grad Sch Med, Kyoto McGill Int Collaborat Sch Genom Med, Kyoto, Japan.;Japan Soc Promot Sci, Tokyo, Japan.,Lady Davis Institute, Jewish General Hospital, McGill University, QC, Montréal, Canada; Department of Human Genetics, McGill University, QC, Montréal, Canada; Kyoto-McGill International Collaborative School in Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan; Research Fellow, Japan Society for the Promotion of Science, Tokyo, Japan (författare)
  • Morrison, David R.McGill Univ, Lady Davis Inst, Jewish Gen Hosp, Montreal, PQ, Canada.,Lady Davis Institute, Jewish General Hospital, McGill University, QC, Montréal, Canada (författare)
  • Afilalo, JonathanMcGill Univ, Lady Davis Inst, Jewish Gen Hosp, Montreal, PQ, Canada.;McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ, Canada.;McGill Univ, Div Cardiol, Dept Med, Montreal, PQ, Canada.,Lady Davis Institute, Jewish General Hospital, McGill University, QC, Montréal, Canada; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, QC, Montréal, Canada; Department of Medicine, Division of Cardiology, McGill University, QC, Montréal, Canada (författare)
  • Afilalo, MarcMcGill Univ, Lady Davis Inst, Jewish Gen Hosp, Montreal, PQ, Canada.;McGill Univ, Jewish Gen Hosp, Dept Emergency Med, Montreal, PQ, Canada.,Lady Davis Institute, Jewish General Hospital, McGill University, QC, Montréal, Canada; Department of Emergency Medicine, Jewish General Hospital, McGill University, QC, Montréal, Canada (författare)
  • Laurent, LaetitiaMcGill Univ, Lady Davis Inst, Jewish Gen Hosp, Montreal, PQ, Canada.,Lady Davis Institute, Jewish General Hospital, McGill University, QC, Montréal, Canada (författare)
  • Pietzner, MaikUniv Cambridge, MRC Epidemiol Unit, Sch Clin Med, Cambridge, England.,MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom (författare)
  • Kerrison, NicolaUniv Cambridge, MRC Epidemiol Unit, Sch Clin Med, Cambridge, England.,MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom (författare)
  • Zhao, KaiqiongMcGill Univ, Lady Davis Inst, Jewish Gen Hosp, Montreal, PQ, Canada.;McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ, Canada.,Lady Davis Institute, Jewish General Hospital, McGill University, QC, Montréal, Canada; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, QC, Montréal, Canada (författare)
  • Brunet-Ratnasingham, ElsaCtr Hosp Univ Montreal, Res Ctr, Montreal, PQ, Canada.;Univ Montreal, Dept Microbiol Infectiol & Immunol, Montreal, PQ, Canada.,Research Centre of the Centre Hospitalier de l’Université de Montréal, QC, Montréal, Canada; Department of Microbiology, Infectiology and Immunology, Université de Montréal, QC, Montréal, Canada (författare)
  • Henry, DanielleMcGill Univ, Lady Davis Inst, Jewish Gen Hosp, Montreal, PQ, Canada.,Lady Davis Institute, Jewish General Hospital, McGill University, QC, Montréal, Canada (författare)
  • Kimchi, NofarMcGill Univ, Lady Davis Inst, Jewish Gen Hosp, Montreal, PQ, Canada.,Lady Davis Institute, Jewish General Hospital, McGill University, QC, Montréal, Canada (författare)
  • Afrasiabi, ZamanMcGill Univ, Lady Davis Inst, Jewish Gen Hosp, Montreal, PQ, Canada.,Lady Davis Institute, Jewish General Hospital, McGill University, QC, Montréal, Canada (författare)
  • Rezk, NardinMcGill Univ, Lady Davis Inst, Jewish Gen Hosp, Montreal, PQ, Canada.,Lady Davis Institute, Jewish General Hospital, McGill University, QC, Montréal, Canada (författare)
  • Bouab, MeriemMcGill Univ, Lady Davis Inst, Jewish Gen Hosp, Montreal, PQ, Canada.,Lady Davis Institute, Jewish General Hospital, McGill University, QC, Montréal, Canada (författare)
  • Petitjean, LouisMcGill Univ, Lady Davis Inst, Jewish Gen Hosp, Montreal, PQ, Canada.,Lady Davis Institute, Jewish General Hospital, McGill University, QC, Montréal, Canada (författare)
  • Guzman, CharlotteMcGill Univ, Lady Davis Inst, Jewish Gen Hosp, Montreal, PQ, Canada.,Lady Davis Institute, Jewish General Hospital, McGill University, QC, Montréal, Canada (författare)
  • Xue, XiaoqingMcGill Univ, Lady Davis Inst, Jewish Gen Hosp, Montreal, PQ, Canada.,Lady Davis Institute, Jewish General Hospital, McGill University, QC, Montréal, Canada (författare)
  • Tselios, ChrisMcGill Univ, Lady Davis Inst, Jewish Gen Hosp, Montreal, PQ, Canada.,Lady Davis Institute, Jewish General Hospital, McGill University, QC, Montréal, Canada (författare)
  • Vulesevic, BrankaMcGill Univ, Lady Davis Inst, Jewish Gen Hosp, Montreal, PQ, Canada.,Lady Davis Institute, Jewish General Hospital, McGill University, QC, Montréal, Canada (författare)
  • Adeleye, OlumideMcGill Univ, Lady Davis Inst, Jewish Gen Hosp, Montreal, PQ, Canada.,Lady Davis Institute, Jewish General Hospital, McGill University, QC, Montréal, Canada (författare)
  • Abdullah, TalaMcGill Univ, Lady Davis Inst, Jewish Gen Hosp, Montreal, PQ, Canada.,Lady Davis Institute, Jewish General Hospital, McGill University, QC, Montréal, Canada (författare)
  • Almamlouk, NoorMcGill Univ, Lady Davis Inst, Jewish Gen Hosp, Montreal, PQ, Canada.,Lady Davis Institute, Jewish General Hospital, McGill University, QC, Montréal, Canada (författare)
  • Chen, YihengMcGill Univ, Lady Davis Inst, Jewish Gen Hosp, Montreal, PQ, Canada.;McGill Univ, Dept Human Genet, Montreal, PQ, Canada.,Lady Davis Institute, Jewish General Hospital, McGill University, QC, Montréal, Canada; Department of Human Genetics, McGill University, QC, Montréal, Canada (författare)
  • Chassé, MichaëlCtr Hosp Univ Montreal, Res Ctr, Montreal, PQ, Canada.,Research Centre of the Centre Hospitalier de l’Université de Montréal, QC, Montréal, Canada (författare)
  • Durand, MadeleineCtr Hosp Univ Montreal, Res Ctr, Montreal, PQ, Canada.,Research Centre of the Centre Hospitalier de l’Université de Montréal, QC, Montréal, Canada (författare)
  • Paterson, ClareSomaLog Inc, Boulder, CO USA.,SomaLogic, Inc., CO, Boulder, United States (författare)
  • Normark, JohanUmeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Immunologi/immunkemi,Wallenberg Center for Molecular Medicine, Umeå Universitet, Sverige(Swepub:umu)jono0053 (författare)
  • Frithiof, RobertUppsala universitet,Anestesiologi och intensivvård,Anaesthesiology and Intensive Care Medicine, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden(Swepub:uu)robfr118 (författare)
  • Lipcsey, MiklósUppsala universitet,Anestesiologi och intensivvård,Hedenstiernalaboratoriet,Anaesthesiology and Intensive Care Medicine, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden; Hedenstierna Laboratory, CIRRUS, Anaesthesiology and Intensive Care Medicine, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden(Swepub:uu)milip123 (författare)
  • Hultström, Michael,1978-Uppsala universitet,Integrativ Fysiologi,Anestesiologi och intensivvård,Anaesthesiology and Intensive Care Medicine, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden; Integrative Physiology, Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden(Swepub:uu)mihul498 (författare)
  • Greenwood, Celia M. T.McGill Univ, Lady Davis Inst, Jewish Gen Hosp, Montreal, PQ, Canada.;McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ, Canada.;McGill Univ, Gerald Bronfman Dept Oncol, Montreal, PQ, Canada.,Lady Davis Institute, Jewish General Hospital, McGill University, QC, Montréal, Canada; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, QC, Montréal, Canada; Gerald Bronfman Department of Oncology, McGill University, QC, Montréal, Canada (författare)
  • Zeberg, HugoKarolinska Institutet,Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden (författare)
  • Langenberg, ClaudiaUniv Cambridge, MRC Epidemiol Unit, Sch Clin Med, Cambridge, England.;Charite Univ Med Berlin, Berlin Inst Hlth, Computat Med, Berlin, Germany.,MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom; Computational Medicine, Berlin Institute of Health, Charité University Medicine Berlin, Berlin, Germany (författare)
  • Thysell, ElinUmeå universitet,Patologi(Swepub:umu)elnsjn00 (författare)
  • Pollak, MichaelMcGill Univ, Lady Davis Inst, Jewish Gen Hosp, Montreal, PQ, Canada.;McGill Univ, Dept Med, Montreal, PQ, Canada.;McGill Univ, Dept Oncol, Montreal, PQ, Canada.,Lady Davis Institute, Jewish General Hospital, McGill University, QC, Montréal, Canada; Departments of Medicine and Oncology, McGill University, QC, Montréal, Canada (författare)
  • Mooser, VincentMcGill Univ, Dept Human Genet, Montreal, PQ, Canada.,Department of Human Genetics, McGill University, QC, Montréal, Canada (författare)
  • Forgetta, VincenzoMcGill Univ, Lady Davis Inst, Jewish Gen Hosp, Montreal, PQ, Canada.,Lady Davis Institute, Jewish General Hospital, McGill University, QC, Montréal, Canada (författare)
  • Kaufmann, Daniel E.Ctr Hosp Univ Montreal, Res Ctr, Montreal, PQ, Canada.;Univ Montreal, Dept Med, Montreal, PQ, Canada.,Research Centre of the Centre Hospitalier de l’Université de Montréal, QC, Montréal, Canada; Department of Medicine, Université de Montréal, QC, Montréal, Canada (författare)
  • Richards, J. BrentMcGill Univ, Lady Davis Inst, Jewish Gen Hosp, Montreal, PQ, Canada.;McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ, Canada.;McGill Univ, Dept Human Genet, Montreal, PQ, Canada.;Kings Coll London, Dept Twin Res, London, England.,Lady Davis Institute, Jewish General Hospital, McGill University, QC, Montréal, Canada; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, QC, Montréal, Canada; Department of Human Genetics, McGill University, QC, Montréal, Canada; Department of Twin Research, King’s College London, London, United Kingdom (författare)
  • McGill Univ, Lady Davis Inst, Jewish Gen Hosp, Montreal, PQ, Canada.;McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ, Canada.Lady Davis Institute, Jewish General Hospital, McGill University, QC, Montréal, Canada; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, QC, Montréal, Canada (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Nature Medicine: Springer Nature27:4, s. 659-6671078-89561546-170X

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