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Patient Preferences for Lung Cancer Treatments: A Study Protocol for a Preference Survey Using Discrete Choice Experiment and Swing Weighting

Monzani, Dario (författare)
Applied Research Division for Cognitive and Psychological Science, IEO, European Institute of Oncology IRCCS, Milan, Italy; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy
Petrocchi, Serena (författare)
Applied Research Division for Cognitive and Psychological Science, IEO, European Institute of Oncology IRCCS, Milan, Italy
Oliveri, Serena (författare)
Applied Research Division for Cognitive and Psychological Science, IEO, European Institute of Oncology IRCCS, Milan, Italy
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Veldwijk, Jorien (författare)
Erasmus School of Health Policy & Management, Erasmus University Rotterdam, Rotterdam, Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands; Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium
Janssens, Rosanne (författare)
Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium
Bailo, Luca (författare)
Applied Research Division for Cognitive and Psychological Science, IEO, European Institute of Oncology IRCCS, Milan, Italy
Smith, Meredith Y. (författare)
Alexion Pharmaceuticals, Inc., Boston, MA, United States; University of Southern California School of Pharmacy, Los Angeles, CA, United States
Smith, Ian (författare)
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands
Schoefs, Elise (författare)
Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium
Nackaerts, Kristiaan (författare)
Department of Respiratory Oncology, University Hospital Leuven, Leuven, Belgium
Vandevelde, Marie (författare)
Department of Respiratory Oncology, University Hospital Leuven, Leuven, Belgium
Louis, Evelyne (författare)
Department of Respiratory Oncology, University Hospital Leuven, Leuven, Belgium
Decaluwé, Herbert (författare)
Department of Thoracic Surgery, KU Leuven, Leuven, Belgium
De Leyn, Paul (författare)
Department of Thoracic Surgery, KU Leuven, Leuven, Belgium
Declerck, Hanne (författare)
Department of Thoracic Surgery, KU Leuven, Leuven, Belgium
Katz, Eva G. (författare)
Janssen Research and Development, LLC, Raritan, NJ, United States
Petrella, Francesco (författare)
Thoracic Surgery Division, IEO, European Institute of Oncology IRCCS, Milan, Italy
Casiraghi, Monica (författare)
Thoracic Surgery Division, IEO, European Institute of Oncology IRCCS, Milan, Italy
Durosini, Ilaria (författare)
Applied Research Division for Cognitive and Psychological Science, IEO, European Institute of Oncology IRCCS, Milan, Italy
Galli, Guilia (författare)
Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
Garassino, Marina Chiara (författare)
University of Chicago Department of Medicine Section Hematology/Oncology, Chicago, IL, United States
de Wit, G. Ardine (författare)
Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium
Pravettoni, Gabriella (författare)
Applied Research Division for Cognitive and Psychological Science, IEO, European Institute of Oncology IRCCS, Milan, Italy; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy
Huys, Isabelle (författare)
Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium
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 (creator_code:org_t)
2021-08-02
2021
Engelska.
Ingår i: Frontiers in Medicine. - : Frontiers Media SA. - 2296-858X. ; 8
Relaterad länk:
https://doi.org/10.3...
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https://www.frontier...
https://urn.kb.se/re...
https://doi.org/10.3...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Background: Advanced treatment options for non-small cell lung cancer (NSCLC) consist of immunotherapy, chemotherapy, or a combination of both. Decisions surrounding NSCLC can be considered as preference-sensitive because multiple treatments exist that vary in terms of mode of administration, treatment schedules, and benefit–risk profiles. As part of the IMI PREFER project, we developed a protocol for an online preference survey for NSCLC patients exploring differences in preferences according to patient characteristics (preference heterogeneity). Moreover, this study will evaluate and compare the use of two different preference elicitation methods, the discrete choice experiment (DCE) and the swing weighting (SW) task. Finally, the study explores how demographic (i.e., age, gender, and educational level) and clinical (i.e., cancer stage and line of treatment) information, health literacy, health locus of control, and quality of life may influence or explain patient preferences and the usefulness of a digital interactive tool in providing information on preference elicitation tasks according to patients.Methods: An online survey will be implemented with the aim to recruit 510 NSCLC patients in Belgium and Italy. Participants will be randomized 50:50 to first receive either the DCE or the SW. The survey will also collect information on participants' disease-related status, health locus of control, health literacy, quality of life, and perception of the educational tool.Discussion: This protocol outlines methodological and practical steps to quantitatively elicit and study patient preferences for NSCLC treatment alternatives. Results from this study will increase the understanding of which treatment aspects are most valued by NSCLC patients to inform decision-making in drug development, regulatory approval, and reimbursement. Methodologically, the comparison between the DCE and the SW task will be valuable to gain information on how these preference methods perform against each other in eliciting patient preferences. Overall, this protocol may assist researchers, drug developers, and decision-makers in designing quantitative patient preferences into decision-making along the medical product life cycle.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Samhällsfarmaci och klinisk farmaci (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Social and Clinical Pharmacy (hsv//eng)

Nyckelord

non-small cell lung cancer
patient preference
discrete choice experiment
swing weighting
educational tool
health literacy
health locus of control
quality of life

Publikations- och innehållstyp

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