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Effects of endocrin...
Effects of endocrine disruptor furan on reproductive physiology of Sprague Dawley rats : An F1 Extended One-Generation Reproductive Toxicity Study (EOGRTS)
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- Rehman, Humaira (författare)
- Uppsala universitet,Institutionen för neurovetenskap,Quaid I Azam Univ, Fac Biol Sci, Dept Anim Sci, Reprod Physiol Lab, Islamabad 44000, Pakistan.
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- Jahan, S. (författare)
- Quaid I Azam Univ, Fac Biol Sci, Dept Anim Sci, Reprod Physiol Lab, Islamabad 44000, Pakistan.
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- Ullah, Imdad (författare)
- Uppsala universitet,Institutionen för neurovetenskap
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- Thörnqvist, Per-Ove (författare)
- Uppsala universitet,Winberg: Beteendeneuroendokrinologi
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- Jabbar, M. (författare)
- Univ Gujrat, Dept Stat, Gujrat, Pakistan.
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- Shoaib, M. (författare)
- Quaid I Azam Univ, Fac Biol Sci, Dept Anim Sci, Reprod Physiol Lab, Islamabad 44000, Pakistan.
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- Aman, F. (författare)
- Quaid I Azam Univ, Fac Biol Sci, Dept Anim Sci, Reprod Physiol Lab, Islamabad 44000, Pakistan.
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- John, N. (författare)
- Quaid I Azam Univ, Fac Biol Sci, Dept Anim Sci, Reprod Physiol Lab, Islamabad 44000, Pakistan.
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(creator_code:org_t)
- 2020-03-16
- 2020
- Engelska.
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Ingår i: Human and Experimental Toxicology. - : SAGE PUBLICATIONS LTD. - 0960-3271 .- 1477-0903. ; 39:8, s. 1079-1094
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The present study investigated the reproductive toxicity of furan in an Extended One-Generation Reproductive Toxicity Study in rats. Sprague Dawley F0 weaning rats (30 per sex per group) were exposed to furan orally at 0, 1, 2.5, 5, and 10 mg kg(-1) for 10 weeks (males) and 2 weeks (females) and then mated. Results of F0 indicated that in the furan-treated groups (5 mg kg(-1) and 10 mg kg(-1)), body weight (bw) gain decreased during prebreed and gestational period while increased during lactation periods. F0 animals prebreeding exposure resulted in head tilt and foot splay at 10 mg kg(-1). Number of live pups at birth were decreased (p < 0.001) at 10 mg kg(-1). At postnatal day (PND) 70, a significant (p = 0.03) decrease in testosterone levels of male rats and estrogen levels of female rats (p = 0.05) was observed in 10 mg kg(-1) furan-treated group in F1 generation. Luteinizing hormone, follicle-stimulating hormone, and progesterone levels were also reduced, but their reduction was not statistically significant in all groups. In higher dose furan group (10 mg kg(-1)), testicular and ovarian weights were reduced in F1 generation at PND 70, with decreased daily sperm production (p = 0.01) and disturbed estrous cyclicity (p < 0.01). Some histopathological changes were also observed in testis and ovaries in groups whose parents were previously exposed to 10 mg kg(-1) bw of furan group. Based on the above results, it is suggested that exposure to food-based contaminant furan induced remarkable changes in the F0 (parental stage) and F1 (offspring, pubertal, and adult stage) generations of Sprague Dawley rats.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Nyckelord
- Furan
- puberty
- Extended One-Generation Reproductive Toxicity Study (EOGRTS)
- histopathology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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