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  • Elbagir, SahwaUppsala universitet,Klinisk immunologi,Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden (författare)

Associations with thrombosis are stronger for antiphosphatidylserine/prothrombin antibodies than for the Sydney criteria antiphospholipid antibody tests in SLE

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • 2021-05-06
  • Sage Publications,2021
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-454290
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-454290URI
  • https://doi.org/10.1177/09612033211014570DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-183590URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:146577652URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Objectives: Antiphosphatidylserine/prothrombin complex antibodies (aPS/PT) are risk factors for thrombosis, yet further validation of their clinical relevance in different ethnic groups is required. We investigated the performance of aPS/PT of IgA/G/M isotypes among Sudanese and Swedish systemic lupus erythematosus (SLE) patients.Methods: Consecutive SLE patients/matched controls from Sudan (n = 91/102) and Sweden (n = 332/163) were included. All patients fulfilled the 1982 ACR SLE classification criteria. IgA/G/M of aPS/PT, anti-cardiolipin and anti-beta(2)glycoprotein I (anti-beta(2)GPI) were tested in both cohorts, and lupus anticoagulant (LA) also in the Swedish cohort. Clinical antiphospholipid syndrome-related events and atherosclerosis, measured as carotid plaques were assessed for associations. Univariate and multivariate analyses adjusting for cardiovascular risk factors were performed.Results: Sudanese SLE patients had higher levels of IgM aPS/PT, but using national cut-offs, the frequency of positivity was similar to Swedish patients for all isotypes. Among Swedish patients, all isotypes of aPS/PT associated with venous thromboembolism (VTE), while only IgA aPS/PT associated with arterial thrombosis (AT). aPS/PT antibodies associated strongly with LA and they were, independently, the best predictor for VTE. Double positivity for aPS/PT and anti-beta(2)GPI associated with higher VTE risk than the conventional triple positivity. Carotid plaques did not associate with any antiphospholipid antibody.Conclusions: IgA aPS/PT associated with AT, and the association of IgG/M aPS/PT with VTE outperforms LA and criteria antiphospholipid antibodies in Swedish SLE patients. Furthermore, double positivity for aPS/PT and anti-beta(2)GPI performed better than conventional triple positivity. Future studies need to address if aPS/PT can replace LA, as this would simplify clinical procedures.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Grosso, GiorgiaKarolinska Institutet,Karolinska Univ Hosp, Karolinska Inst, Dept Med Solna, Div Rheumatol, Stockholm, Sweden. (författare)
  • Mohammed, NasrEldeen A.Al Neelain Univ, Fac Med Lab Sci, Khartoum, Sudan.,Faculty of Medical Laboratory Sciences, Al Neelain University, Khartoum, Sudan (författare)
  • ElShafie, Amir Ibrahim,1970-Umeå universitet,Uppsala universitet,Klinisk immunologi,Umeå Univ, Dept Med Biosci, Pathol, Umeå, Sweden.,Patologi,Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden(Swepub:uu)amiel226 (författare)
  • Elagib, Elnour M.Mil Hosp, Rheumatol Unit, Omdurman, Sudan.,Rheumatology Unit, Military Hospital, Omdurman, Sudan (författare)
  • Zickert, AgnetaKarolinska Institutet,Karolinska Univ Hosp, Karolinska Inst, Dept Med Solna, Div Rheumatol, Stockholm, Sweden. (författare)
  • Manivel, Vivek AnandUppsala universitet,Klinisk immunologi,Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden(Swepub:uu)vivan468 (författare)
  • Pertsinidou, EleftheriaUppsala universitet,Klinisk immunologi,Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden(Swepub:uu)elepe248 (författare)
  • Nur, Musa A. M.Alribat Univ Hosp, Rheumatol Unit, Khartoum, Sudan.,Rheumatology Unit, Alribat University Hospital, Khartoum, Sudan (författare)
  • Gunnarsson, IvaKarolinska Institutet,Karolinska Univ Hosp, Karolinska Inst, Dept Med Solna, Div Rheumatol, Stockholm, Sweden. (författare)
  • Rönnelid, JohanUppsala universitet,Klinisk immunologi,Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden(Swepub:uu)joharonn (författare)
  • Svenungsson, ElisabetKarolinska Institutet,Karolinska Univ Hosp, Karolinska Inst, Dept Med Solna, Div Rheumatol, Stockholm, Sweden. (författare)
  • Uppsala universitetKlinisk immunologi (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Lupus: Sage Publications30:8, s. 1289-12990961-20331477-0962

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