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Associations with thrombosis are stronger for antiphosphatidylserine/prothrombin antibodies than for the Sydney criteria antiphospholipid antibody tests in SLE
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- Elbagir, Sahwa (författare)
- Uppsala universitet,Klinisk immunologi,Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
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- Grosso, Giorgia (författare)
- Karolinska Institutet,Karolinska Univ Hosp, Karolinska Inst, Dept Med Solna, Div Rheumatol, Stockholm, Sweden.
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- Mohammed, NasrEldeen A. (författare)
- Al Neelain Univ, Fac Med Lab Sci, Khartoum, Sudan.,Faculty of Medical Laboratory Sciences, Al Neelain University, Khartoum, Sudan
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- ElShafie, Amir Ibrahim, 1970- (författare)
- Umeå universitet,Uppsala universitet,Klinisk immunologi,Umeå Univ, Dept Med Biosci, Pathol, Umeå, Sweden.,Patologi,Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
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- Elagib, Elnour M. (författare)
- Mil Hosp, Rheumatol Unit, Omdurman, Sudan.,Rheumatology Unit, Military Hospital, Omdurman, Sudan
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- Zickert, Agneta (författare)
- Karolinska Institutet,Karolinska Univ Hosp, Karolinska Inst, Dept Med Solna, Div Rheumatol, Stockholm, Sweden.
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- Manivel, Vivek Anand (författare)
- Uppsala universitet,Klinisk immunologi,Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
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- Pertsinidou, Eleftheria (författare)
- Uppsala universitet,Klinisk immunologi,Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
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- Nur, Musa A. M. (författare)
- Alribat Univ Hosp, Rheumatol Unit, Khartoum, Sudan.,Rheumatology Unit, Alribat University Hospital, Khartoum, Sudan
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- Gunnarsson, Iva (författare)
- Karolinska Institutet,Karolinska Univ Hosp, Karolinska Inst, Dept Med Solna, Div Rheumatol, Stockholm, Sweden.
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- Rönnelid, Johan (författare)
- Uppsala universitet,Klinisk immunologi,Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
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- Svenungsson, Elisabet (författare)
- Karolinska Institutet,Karolinska Univ Hosp, Karolinska Inst, Dept Med Solna, Div Rheumatol, Stockholm, Sweden.
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(creator_code:org_t)
- 2021-05-06
- 2021
- Engelska.
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Ingår i: Lupus. - : Sage Publications. - 0961-2033 .- 1477-0962. ; 30:8, s. 1289-1299
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objectives: Antiphosphatidylserine/prothrombin complex antibodies (aPS/PT) are risk factors for thrombosis, yet further validation of their clinical relevance in different ethnic groups is required. We investigated the performance of aPS/PT of IgA/G/M isotypes among Sudanese and Swedish systemic lupus erythematosus (SLE) patients.Methods: Consecutive SLE patients/matched controls from Sudan (n = 91/102) and Sweden (n = 332/163) were included. All patients fulfilled the 1982 ACR SLE classification criteria. IgA/G/M of aPS/PT, anti-cardiolipin and anti-beta(2)glycoprotein I (anti-beta(2)GPI) were tested in both cohorts, and lupus anticoagulant (LA) also in the Swedish cohort. Clinical antiphospholipid syndrome-related events and atherosclerosis, measured as carotid plaques were assessed for associations. Univariate and multivariate analyses adjusting for cardiovascular risk factors were performed.Results: Sudanese SLE patients had higher levels of IgM aPS/PT, but using national cut-offs, the frequency of positivity was similar to Swedish patients for all isotypes. Among Swedish patients, all isotypes of aPS/PT associated with venous thromboembolism (VTE), while only IgA aPS/PT associated with arterial thrombosis (AT). aPS/PT antibodies associated strongly with LA and they were, independently, the best predictor for VTE. Double positivity for aPS/PT and anti-beta(2)GPI associated with higher VTE risk than the conventional triple positivity. Carotid plaques did not associate with any antiphospholipid antibody.Conclusions: IgA aPS/PT associated with AT, and the association of IgG/M aPS/PT with VTE outperforms LA and criteria antiphospholipid antibodies in Swedish SLE patients. Furthermore, double positivity for aPS/PT and anti-beta(2)GPI performed better than conventional triple positivity. Future studies need to address if aPS/PT can replace LA, as this would simplify clinical procedures.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- Antiphosphatidylserine
- prothrombin
- carotid plaques
- lupus anticoagulant
- systemic lupus erythematosus
- thrombosis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Elbagir, Sahwa
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Grosso, Giorgia
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Mohammed, NasrEl ...
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ElShafie, Amir I ...
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Elagib, Elnour M ...
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Zickert, Agneta
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Manivel, Vivek A ...
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Pertsinidou, Ele ...
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Nur, Musa A. M.
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Gunnarsson, Iva
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Rönnelid, Johan
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Svenungsson, Eli ...
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