Impact of chronic obstructive pulmonary disease on 10-year mortality after percutaneous coronary intervention and bypass surgery for complex coronary artery disease: insights from the SYNTAX Extended Survival study

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Impact of chronic obstructive pulmonary disease on 10-year mortality after percutaneous coronary intervention and bypass surgery for complex coronary artery disease : insights from the SYNTAX Extended Survival study

Wang, Rutao (författare): Xijing Hosp, Dept Cardiol, Xian, Peoples R China.;Natl Univ Ireland, Galway NUIG, Dept Cardiol, PO Univ Rd, Galway H91 TK33, Ireland.;Radboud Univ Nijmegen, Med Ctr, Dept Cardiol, Nijmegen, Netherlands.

Tomaniak, Mariusz (författare): Med Univ Warsaw, Dept Cardiol 1, Warsaw, Poland.;Erasmus MC, Dept Cardiol, Rotterdam, Netherlands.

Takahashi, Kuniaki (författare): Univ Amsterdam, Locat Acad Med Ctr, Med Ctr, Dept Cardiol, Amsterdam, Netherlands.

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Gao, Chao (författare): Xijing Hosp, Dept Cardiol, Xian, Peoples R China.;Natl Univ Ireland, Galway NUIG, Dept Cardiol, PO Univ Rd, Galway H91 TK33, Ireland.;Radboud Univ Nijmegen, Med Ctr, Dept Cardiol, Nijmegen, Netherlands.

Kawashima, Hideyuki (författare): Natl Univ Ireland, Galway NUIG, Dept Cardiol, PO Univ Rd, Galway H91 TK33, Ireland.;Univ Amsterdam, Locat Acad Med Ctr, Med Ctr, Dept Cardiol, Amsterdam, Netherlands.

Hara, Hironori (författare): Natl Univ Ireland, Galway NUIG, Dept Cardiol, PO Univ Rd, Galway H91 TK33, Ireland.;Univ Amsterdam, Locat Acad Med Ctr, Med Ctr, Dept Cardiol, Amsterdam, Netherlands.

Ono, Masafumi (författare): Natl Univ Ireland, Galway NUIG, Dept Cardiol, PO Univ Rd, Galway H91 TK33, Ireland.;Univ Amsterdam, Locat Acad Med Ctr, Med Ctr, Dept Cardiol, Amsterdam, Netherlands.

van Klaveren, David (författare): Erasmus MC, Dept Publ Hlth, Rotterdam, Netherlands.;Tufts Med Ctr, Inst Clin Res & Hlth Policy Studies, Predict Analyt & Comparat Effectiveness Ctr, Boston, MA 02111 USA.

van Geuns, Robert-Jan (författare): Radboud Univ Nijmegen, Med Ctr, Dept Cardiol, Nijmegen, Netherlands.

Morice, Marie-Claude (författare): ICPS Ramsay Gen Sante, Massy, France.

Davierwala, Piroze M. (författare): Heart Ctr Leipzig, Dept Cardiac Surg, Leipzig, Germany.

Mack, Michael J. (författare): Baylor Scott & White Hlth, Plano, TX USA.

Witkowski, Adam (författare): Natl Inst Cardiol, Dept Intervent Cardiol & Angiol, Warsaw, Poland.

Curzen, Nick (författare): Univ Hosp Southampton, Cardiol Dept, Southampton, Hants, England.

Berti, Sergio (författare): Fdn CNR Reg Toscana G Monasterio, Heart Hosp, Cardiol Dept, Massa, Italy.

Burzotta, Francesco (författare): Univ Cattolica Sacro Cuore, IRCCS, Fdn Policlin Univ Agostino Gemelli, Inst Cardiol, Rome, Italy.

James, Stefan, 1964- (författare): Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)

Kappetein, Arie Pieter (författare): Erasmus MC, Dept Cardiothorac Surg, Rotterdam, Netherlands.

Head, Stuart J. (författare): Erasmus MC, Dept Cardiothorac Surg, Rotterdam, Netherlands.

Thuijs, Daniel J. F. M. (författare): Erasmus MC, Dept Cardiothorac Surg, Rotterdam, Netherlands.

Mohr, Friedrich W. (författare): Heart Ctr Leipzig, Dept Cardiac Surg, Leipzig, Germany.

Holmes, David R. (författare): Mayo Clin, Rochester, MN USA.

Tao, Ling (författare): Xijing Hosp, Dept Cardiol, Xian, Peoples R China.

Onuma, Yoshinobu (författare): Natl Univ Ireland, Galway NUIG, Dept Cardiol, PO Univ Rd, Galway H91 TK33, Ireland.

Serruys, Patrick W. (författare): Natl Univ Ireland, Galway NUIG, Dept Cardiol, PO Univ Rd, Galway H91 TK33, Ireland.;Imperial Coll London, NHLI, London, England.;Erasmus MC, Rotterdam, Netherlands.

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Xijing Hosp, Dept Cardiol, Xian, Peoples R China;Natl Univ Ireland, Galway NUIG, Dept Cardiol, PO Univ Rd, Galway H91 TK33, Ireland.;Radboud Univ Nijmegen, Med Ctr, Dept Cardiol, Nijmegen, Netherlands. Med Univ Warsaw, Dept Cardiol 1, Warsaw, Poland.;Erasmus MC, Dept Cardiol, Rotterdam, Netherlands. (creator_code:org_t)

2021-03-12
2021
Engelska.
Ingår i: Clinical Research in Cardiology. - : Springer Nature. - 1861-0684 .- 1861-0692. ; 110:7, s. 1083-1095

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AimsTo evaluate the impact of chronic obstructive pulmonary disease (COPD) on 10-year all-cause death and the treatment effect of CABG versus PCI on 10-year all-cause death in patients with three-vessel disease (3VD) and/or left main coronary artery disease (LMCAD) and COPD.MethodsPatients were stratified according to COPD status and compared with regard to clinical outcomes. Ten-year all-cause death was examined according to the presence of COPD and the revascularization strategy.ResultsCOPD status was available for all randomized 1800 patients, of whom, 154 had COPD (8.6%) at the time of randomization. Regardless of the revascularization strategy, patients with COPD had a higher risk of 10-year all-cause death, compared with those without COPD (43.1% vs. 24.9%; hazard ratio [HR]: 2.03; 95% confidence interval [CI]: 1.56–2.64; p < 0.001). Among patients with COPD, CABG appeared to have a slightly lower risk of 10-year all-cause death compared with PCI (42.3% vs. 43.9%; HR: 0.96; 95% CI: 0.59–1.56, p = 0.858), whereas among those without COPD, CABG had a significantly lower risk of 10-year all-cause death (22.7% vs. 27.1%; HR: 0.81; 95% CI: 0.67–0.99, p = 0.041). There was no significant differential treatment effect of CABG versus PCI on 10-year all-cause death between patients with and without COPD (p interaction = 0.544).ConclusionsCOPD was associated with a higher risk of 10-year all-cause death after revascularization for complex coronary artery disease. The presence of COPD did not significantly modify the beneficial effect of CABG versus PCI on 10-year all-cause death.Trial registration: SYNTAX: ClinicalTrials.gov reference: NCT00114972. SYNTAX Extended Survival: ClinicalTrials.gov reference: NCT03417050

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kardiologi

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Impact of chronic obstructive pulmonary disease on 10-year mortality after percutaneous coronary intervention and bypass surgery for complex coronary artery disease : insights from the SYNTAX Extended Survival study

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