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  • Söfteland, John M.,1977Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery (author)

COVID-19 in solid organ transplant recipients : A national cohort study from Sweden

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • John Wiley & Sons,2021
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-454480
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-454480URI
  • https://doi.org/10.1111/ajt.16596DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:146468754URI
  • https://gup.ub.gu.se/publication/303123URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Solid organ transplant (SOT) recipients run a high risk for adverse outcomes from COVID-19, with reported mortality around 19%. We retrospectively reviewed all known Swedish SOT recipients with RT-PCR confirmed COVID-19 between March 1 and November 20, 2020 and analyzed patient characteristics, management, and outcome. We identified 230 patients with a median age of 54.0 years (13.2), who were predominantly male (64%). Most patients were hospitalized (64%), but 36% remained outpatients. Age >50 and male sex were among predictors of transition from outpatient to inpatient status. National early warning Score 2 (NEWS2) at presentation was higher in non-survivors. Thirty-day all-cause mortality was 9.6% (15.0% for inpatients), increased with age and BMI, and was higher in men. Renal function decreased during COVID-19 but recovered in most patients. SARS-CoV-2 antibodies were identified in 78% of patients at 1-2 months post-infection. Nucleocapsid-specific antibodies decreased to 38% after 6-7 months, while spike-specific antibody responses were more durable. Seroprevalence in 559 asymptomatic patients was 1.4%. Many patients can be managed on an outpatient basis aided by risk stratification with age, sex, and NEWS2 score. Factors associated with adverse outcomes include older age, male sex, greater BMI, and a higher NEWS2 score.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Friman, GustavKarolinska Univ Hosp, Dept Transplantat Surg, Stockholm, Sweden. (author)
  • von Zur-Mühlen, Bengt,Docent,1966-Uppsala universitet,Transplantationskirurgi(Swepub:uu)bengmuhl (author)
  • Ericzon, Bo-GöranKarolinska Institutet (author)
  • Wallquist, CarinSkane Univ Hosp, Dept Nephrol, Malmö, Sweden. (author)
  • Karason, KristjanSahlgrens Univ Hosp, Transplant Inst, Gothenburg, Sweden. (author)
  • Friman, Vanda,1952Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine(Swepub:gu)xfriva (author)
  • Ekelund, JanVastra Gotaland, Ctr Registers, Gothenburg, Sweden. (author)
  • Felldin, MarieSahlgrens Univ Hosp, Transplant Inst, Gothenburg, Sweden. (author)
  • Magnusson, JesperSahlgrens Univ Hosp, Transplant Inst, Gothenburg, Sweden. (author)
  • Haugen Löfman, IdaKarolinska Univ Hosp, Dept Cardiol, Stockholm, Sweden. (author)
  • Schult, AndreasSahlgrens Univ Hosp, Transplant Inst, Gothenburg, Sweden. (author)
  • de Coursey, EmilySahlgrens Univ Hosp, Transplant Inst, Gothenburg, Sweden. (author)
  • Leach, Susannah,1983Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology(Swepub:gu)xleasu (author)
  • Jacobsson, HannaSahlgrens Univ Hosp, Transplant Inst, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Biobank West, Gothenburg, Sweden. (author)
  • Liljeqvist, Jan-Åke,1954Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine(Swepub:gu)xljanl (author)
  • Biglarnia, Ali R.Skane Univ Hosp, Dept Transplantat Surg, Malmö, Sweden. (author)
  • Lindnér, Per,1956Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery(Swepub:gu)xlperr (author)
  • Oltean, Mihai,1976Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery(Swepub:gu)xoltmi (author)
  • Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för kirurgi (creator_code:org_t)

Related titles

  • In:American Journal of Transplantation: John Wiley & Sons21:8, s. 2762-27731600-61351600-6143

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