A novel podocyte protein, R3h domain containing-like, inhibits TGF-β-induced p38 MAPK and regulates the structure of podocytes and glomerular basement membrane

Ishikawa, TakahiroChiba Univ, Dept Endocrinol Hematol & Gerontol, Grad Sch Med, Chiba 2608670, Japan (författare)

Title in Web of Science: A novel podocyte protein, R3h domain containing-like, inhibits TGF-beta-induced p38 MAPK and regulates the structure of podocytes and glomerular basement membrane
Not only in kidney glomerular physiological function but also glomerular pathology especially in diabetic condition, glomerular podocytes play pivotal roles. Therefore, it is important to increase our knowledge about the genes and proteins expressed in podocytes. Recently, we have identified a novel podocyte-expressed gene, R3h domain containing-like (R3hdml) and analyzed its function in vivo as well as in vitro. Transforming growth factor-β (TGF-β) signaling regulated the expression of R3hdml. And R3hdml inhibited p38 mitogen-activated protein kinase phosphorylation, which was induced by TGF-β, leading to the amelioration of podocyte apoptosis. Furthermore, a lack of R3hdml in mice significantly worsened glomerular function in streptozotocin (STZ)-induced diabetes, while overexpression of R3hdml ameliorated albuminuria in STZ-induced diabetes. Our results surmise that the functional analyses of R3hdml may lead to the development of novel therapeutic strategies for diabetic nephropathy in the future.

Takemoto, MinoruInt Univ Hlth & Welf, Sch Med, Dept Diabet Metab & Endocrinol, 4-3 Kozunomori, Narita, Chiba 2868686, Japan (författare)
Akimoto, YoshihiroKyorin Univ, Dept Anat, Sch Med, Tokyo, Japan (författare)
Takada-Watanabe, AkiChiba Univ, Dept Endocrinol Hematol & Gerontol, Grad Sch Med, Chiba 2608670, Japan (författare)
Yan, KunimasaKyorin Univ, Dept Pediat, Sch Med, Tokyo, Japan (författare)
Sakamoto, KenichiChiba Univ, Dept Endocrinol Hematol & Gerontol, Grad Sch Med, Chiba 2608670, Japan (författare)
Maezawa, YoshiroChiba Univ, Dept Endocrinol Hematol & Gerontol, Grad Sch Med, Chiba 2608670, Japan (författare)
Suguro, MiyukiAichi Canc Ctr, Res Inst, Nagoya, Aichi, Japan (författare)
He, LiqunUppsala universitet,Vaskulärbiologi(Swepub:uu)liqhe592 (författare)
Tryggvason, KarlDuke NUS Grad Med Sch Singapore, Cardiovasc & Metab Disorders Program, Singapore, Singapore (författare)
Betsholtz, ChristerUppsala universitet,Vaskulärbiologi,Karolinska Inst, Dept Med Huddinge, Campus Flemingsberg, SE-14157 Huddinge, Sweden(Swepub:uu)chbet517 (författare)
Yokote, KoutaroChiba Univ, Dept Endocrinol Hematol & Gerontol, Grad Sch Med, Chiba 2608670, Japan (författare)
Chiba Univ, Dept Endocrinol Hematol & Gerontol, Grad Sch Med, Chiba 2608670, JapanInt Univ Hlth & Welf, Sch Med, Dept Diabet Metab & Endocrinol, 4-3 Kozunomori, Narita, Chiba 2868686, Japan (creator_code:org_t)

Ingår i:Journal of Molecular Medicine: Springer Science and Business Media LLC99:6, s. 859-8760946-27161432-1440

Av författaren/redakt...: Ishikawa, Takahi ...; Takemoto, Minoru; Akimoto, Yoshihi ...; Takada-Watanabe, ...; Yan, Kunimasa; Sakamoto, Kenich ...; visa fler...; Maezawa, Yoshiro; Suguro, Miyuki; He, Liqun; Tryggvason, Karl; Betsholtz, Chris ...; Yokote, Koutaro; visa färre...

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