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Re-appraisal of the obesity paradox in heart failure : a meta-analysis of individual data

Marcks, Nick (författare)
Maastricht Univ, Med Ctr, Dept Cardiol, POB 5800, NL-6202AZ Maastricht, Netherlands.
Aimo, Alberto (författare)
Univ Hosp Pisa, Cardiol Div, Pisa, Italy.
Januzzi, James L., Jr. (författare)
Massachusetts Gen Hosp, Boston, MA 02114 USA.;Baim Inst Clin Res, Boston, MA USA.
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Vergaro, Giuseppe (författare)
Scuola Super Sant Anna, Inst Life Sci, Pisa, Italy.;Fdn Toscana G Monasterio, Pisa, Italy.
Clerico, Aldo (författare)
Scuola Super Sant Anna, Inst Life Sci, Pisa, Italy.;Fdn Toscana G Monasterio, Pisa, Italy.
Latini, Roberto (författare)
IRCCS, Inst Pharmacol Res Mario Negri, Dept Cardiovasc Med, Milan, Italy.
Meessen, Jennifer (författare)
IRCCS, Inst Pharmacol Res Mario Negri, Dept Cardiovasc Med, Milan, Italy.
Anand, Inder S. (författare)
Univ Minnesota, Div Cardiovasc Med, Minneapolis, MN USA.;VA Med Ctr, Dept Cardiol, Minneapolis, MN USA.
Cohn, Jay N. (författare)
Univ Minnesota, Div Cardiovasc Med, Minneapolis, MN USA.
Gravning, Jorgen (författare)
Oslo Univ Hosp, Dept Cardiol, Oslo, Norway.;Univ Oslo, Ctr Heart Failure Res, Oslo, Norway.
Ueland, Thor (författare)
Oslo Univ Hosp, Rikshosp, Res Inst Internal Med, Oslo, Norway.;Univ Oslo, Fac Med, Oslo, Norway.;Univ Tromso, KG Jebsen Thrombosis Res & Expertise Ctr, Tromso, Norway.
Bayes-Genis, Antoni (författare)
Hosp Univ Germans Trias I Pujol, Badalona, Spain.
Lupon, Josep (författare)
Hosp Univ Germans Trias I Pujol, Badalona, Spain.
de Boer, Rudolf A. (författare)
Univ Med Ctr Groningen, Groningen, Netherlands.
Yoshihisa, Akiomi (författare)
Fukushima Med Univ, Dept Cardiovasc Med, Fukushima, Japan.
Takeishi, Yasuchika (författare)
Fukushima Med Univ, Dept Cardiovasc Med, Fukushima, Japan.
Egstrup, Michael (författare)
Bispebjerg Hosp, Dept Cardiol, Copenhagen, Denmark.
Gustafsson, Ida (författare)
Bispebjerg Hosp, Dept Cardiol, Copenhagen, Denmark.
Gaggin, Hanna K. (författare)
Massachusetts Gen Hosp, Boston, MA 02114 USA.;Baim Inst Clin Res, Boston, MA USA.
Eggers, Kai M., 1962- (författare)
Uppsala universitet,Kardiologi
Huber, Kurt (författare)
Wilhelminenspital Stadt Wien, Fac Internal Med, Vienna, Austria.;Sigmund Freud Univ, Med Sch, Vienna, Austria.
Tentzeris, Ioannis (författare)
Wilhelminenspital Stadt Wien, Fac Internal Med, Vienna, Austria.;Sigmund Freud Univ, Med Sch, Vienna, Austria.
Ripoli, Andrea (författare)
Fdn Toscana G Monasterio, Pisa, Italy.
Passino, Claudio (författare)
Scuola Super Sant Anna, Inst Life Sci, Pisa, Italy.;Fdn Toscana G Monasterio, Pisa, Italy.
Sanders-van Wijk, Sandra (författare)
Maastricht Univ, Med Ctr, Dept Cardiol, POB 5800, NL-6202AZ Maastricht, Netherlands.
Emdin, Michele (författare)
Scuola Super Sant Anna, Inst Life Sci, Pisa, Italy.;Fdn Toscana G Monasterio, Pisa, Italy.
Brunner-La Rocca, Hans-Peter (författare)
Maastricht Univ, Med Ctr, Dept Cardiol, POB 5800, NL-6202AZ Maastricht, Netherlands.
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Maastricht Univ, Med Ctr, Dept Cardiol, POB 5800, NL-6202AZ Maastricht, Netherlands Univ Hosp Pisa, Cardiol Div, Pisa, Italy. (creator_code:org_t)
2021-03-11
2021
Engelska.
Ingår i: Clinical Research in Cardiology. - : Springer Nature. - 1861-0684 .- 1861-0692. ; 110:8, s. 1280-1291
Relaterad länk:
https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Background Higher body mass index (BMI) is associated with better outcome compared with normal weight in patients with HF and other chronic diseases. It remains uncertain whether the apparent protective role of obesity relates to the absence of comorbidities. Therefore, we investigated the effect of BMI on outcome in younger patients without co-morbidities as compared to older patients with co-morbidities in a large heart failure (HF) population. Methods In an individual patient data analysis from pooled cohorts, 5,819 patients with chronic HF and data available on BMI, co-morbidities and outcome were analysed. Patients were divided into four groups based on BMI (i.e. <= 18.5 kg/m(2), 18.5-25.0 kg/m(2); 25.0-30.0 kg/m(2); 30.0 kg/m(2)). Primary endpoints included all-cause mortality and HF hospitalization-free survival. Results Mean age was 65 +/- 12 years, with a majority of males (78%), ischaemic HF and HF with reduced ejection fraction. Frequency of all-cause mortality or HF hospitalization was significantly worse in the lowest two BMI groups as compared to the other two groups; however, this effect was only seen in patients older than 75 years or having at least one relevant co-morbidity, and not in younger patients with HF only. After including medications and N-terminal pro-B-type natriuretic peptide and high-sensitivity cardiac troponin concentrations into the model, the prognostic impact of BMI was largely absent even in the elderly group with co-morbidity. Conclusions The present study suggests that obesity is a marker of less advanced disease, but does not have an independent protective effect in patients with chronic HF. [GRAPHICS] .

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

Nyckelord

Heart failure
Obesity
Body mass index
Disease severity
Co-morbidities
Biomarkers

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