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  • Sturkenboom, Marieke G. G.Univ Groningen, Univ Med Ctr Groningen, Dept Clin Pharm & Pharmacol, Groningen, Netherlands. (författare)

Population Pharmacokinetics and Bayesian Dose Adjustment to Advance TDM of Anti-TB Drugs

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • 2021-03-06
  • ADIS INT LTD,2021
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-454754
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-454754URI
  • https://doi.org/10.1007/s40262-021-00997-0DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:for swepub-publicationtype

Anmärkningar

  • Tuberculosis (TB) is still the number one cause of death due to an infectious disease. Pharmacokinetics and pharmacodynamics of anti-TB drugs are key in the optimization of TB treatment and help to prevent slow response to treatment, acquired drug resistance, and adverse drug effects. The aim of this review was to provide an update on the pharmacokinetics and pharmacodynamics of anti-TB drugs and to show how population pharmacokinetics and Bayesian dose adjustment can be used to optimize treatment. We cover aspects on preclinical, clinical, and population pharmacokinetics of different drugs used for drug-susceptible TB and multidrug-resistant TB. Moreover, we include available data to support therapeutic drug monitoring of these drugs and known pharmacokinetic and pharmacodynamic targets that can be used for optimization of therapy. We have identified a wide range of population pharmacokinetic models for first- and second-line drugs used for TB, which included models built on NONMEM, Pmetrics, ADAPT, MWPharm, Monolix, Phoenix, and NPEM2 software. The first population models were built for isoniazid and rifampicin; however, in recent years, more data have emerged for both new anti-TB drugs, but also for defining targets of older anti-TB drugs. Since the introduction of therapeutic drug monitoring for TB over 3 decades ago, further development of therapeutic drug monitoring in TB next steps will again depend on academic and clinical initiatives. We recommend close collaboration between researchers and the World Health Organization to provide important guideline updates regarding therapeutic drug monitoring and pharmacokinetics/pharmacodynamics.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Martson, Anne-GreteUniv Groningen, Univ Med Ctr Groningen, Dept Clin Pharm & Pharmacol, Groningen, Netherlands. (författare)
  • Svensson, Elin,1985-Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Institutionen för farmaci,Uppsala Univ, Dept Pharm, Uppsala, Sweden.;Radboud Univ Nijmegen Med Ctr, Radboud Inst Hlth Sci, Dept Pharm, Nijmegen, Netherlands.(Swepub:uu)elisv718 (författare)
  • Sloan, Derek J.Univ Liverpool, Inst Infect & Global Hlth, Liverpool, Merseyside, England.;Univ Liverpool Liverpool Sch Trop Med, Liverpool, Merseyside, England.;Univ St Andrews, Sch Med, St Andrews, Fife, Scotland. (författare)
  • Dooley, Kelly E.Johns Hopkins Univ, Sch Med, Dept Med, Ctr TB Res, Baltimore, MD 21205 USA. (författare)
  • van den Elsen, Simone H. J.Univ Groningen, Univ Med Ctr Groningen, Dept Clin Pharm & Pharmacol, Groningen, Netherlands.;Hosp Grp Twente, Dept Clin Pharm, Almelo, Hengelo, Netherlands. (författare)
  • Denti, PaoloUniv Cape Town, Div Clin Pharmacol, Dept Med, Cape Town, South Africa. (författare)
  • Peloquin, Charles A.Univ Florida, Coll Pharm, Dept Pharmacotherapy & Translat Res, Gainesville, FL USA. (författare)
  • Aarnoutse, Rob E.Radboud Univ Nijmegen Med Ctr, Radboud Inst Hlth Sci, Dept Pharm, Nijmegen, Netherlands. (författare)
  • Alffenaar, Jan-Willem C.Univ Groningen, Univ Med Ctr Groningen, Dept Clin Pharm & Pharmacol, Groningen, Netherlands.;Univ Sydney, Sch Pharm, Fac Med & Hlth, Pharm Bldg A15, Sydney, NSW 2006, Australia.;Westmead Hosp, Westmead, NSW, Australia.;Univ Sydney, Marie Bashir Inst Infect Dis & Biosecur, Sydney, NSW, Australia. (författare)
  • Univ Groningen, Univ Med Ctr Groningen, Dept Clin Pharm & Pharmacol, Groningen, Netherlands.Institutionen för farmaceutisk biovetenskap (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Clinical Pharmacokinetics: ADIS INT LTD60:6, s. 685-7100312-59631179-1926

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